Implicación de rs924607 del gen CEP72 en la neurotoxicidad asociada a la vincristina en pacientes con leucemia linfoblastica aguda (LLA)

Este trabajo se trata de un estudio estadístico de asociación entre el genotipo del SNP rs924607 presente en la región promotora del gen CEP72, y la neurotoxicidad asociada a la vincristina, en pacientes pediátricos de Leucemia Linfoblástica Aguda. El objetivo es determinar si el alelo presente en dicho SNP puede ser empleado como biomarcador para predecir la neurotoxicidad asociada a la vincristina.

Estrés y estado funcional de salud en padres y madres de niños con leucemia linfoblástica aguda (LLA).

Tesis (Maestría en Ciencias con Opción en Psicología de la Salud) UANL, 2012.

Determinación de genes regulados por microRNAs, involucrados en la leucemia linfocítica aguda tipo B (LLA-B).

Tesis (Doctorado en Ciencias con Orientación en Biología Molecular e Ingeniería Genética) UANL, 2013.

Caminando Asturias : ruta 3 : Parque Natural de Redes (Foces de Lla??mo)

Caminando Asturias es una acci??n enmarcada en el Programa de Actividades Complementarias y Extraescolares que promueve la Consejer??a de Educaci??n y Ciencia de Asturias. Est?? orientado a promover actividades de car??cter formativo y convivencial, fomentando la pr??ctica de los mejores valores humanos que siempre se dan en pleno medio natural, las relaciones sociales y de compa??erismo, al tiempo que contribuye a una adecuada educaci??n medioambiental. En este sentido, trata de potenciar el estudio y disfrute de los recursos naturales, como un elemento que contribuye a la Formaci??n Integral de los alumnos. As?? mismo, se pretende fomentar las pr??cticas de educaci??n no formal, ni reglada, vertebradas a trav??s de las actividades extraescolares y complementarias. Por ??ltimo, como objetivo b??sico se busca fomentar y facilitar la participaci??n de las familias en las actividades de los centros docentes. El programa se dirige a alumnos de los colegios p??blicos e institutos de ense??anza secundaria, a sus familias y a sus profesores, y va preferentemente dirigido a alumnos y alumnas matriculados en el tercer ciclo de Primaria (quinto y sexto) y de la ESO (primero a cuarto). Este d??ptico recoge la informaci??n, itinerario y mapa de la ruta Foces de Lla??mo o Ruta del Alba, que discurre en el Parque Natural de Redes.

Investigação do funcionamento cognitivo de pacientes pediátricos diagnosticados com leucemia linfóide aguda - LLA

The present work investigated the cognitive operation of children diagnosed with acute lymphoblastic leukaemia (ALL), accompanied at pediatric oncologic institutions at the city of Natal/RN. Had participated in this study twenty children, of both sexes, between six and twelve years old, with the ALL diagnostic, who were in treatment (n=10) and out of treatment for at least one year (n=10) and were submitted exclusively to chemotherapy as CNS prophylaxis. The utilized protocol of neuropsychological evaluation covered the following cognitive abilities: intellective capability, attentional and memory systems, and executive functions. Data was analyzed through descriptive and inferential measures, with the support of the Mann-Whitney U Test and T-test, considering the influence of the variables sex, age at diagnostic and the past time since the beginning of the treatment over children s performance. The intellective capability evaluation showed low score to the out-of-treatment groups, female and children under five years old to the diagnostic. In concern of attentional systems, groups showed the expected performance. In a relevant way, in the evaluation of executive functions, were found reduced scores within all groups, especially inside the in-treatment group. Memory evaluation pointed to reduced performance in items concerning to learning evolution and spontaneous evocation after interference to the several groups. It can be concluded, reffer to the occurrence of transitory and permanent impact associated to the intrusion of chemotherapic components during the maturational course of the CNS. It s expected that the present investigation and the development of similar studies enable major comprehension about the mode, extension and repercussion of these damages subsidizing the development of strategies which may minimize them and provide better xxiii life quality to this clinical subgroup

Avaliação das habilidades neurocognitivas em crianças e adolescentes sobreviventes da Leucemia Linfoide Aguda - LLA

The present study investigated the impact of the treatment modalities of Acute Lymphoblastic Leukemia on neurocognitive abilities of children and adolescents survivors, aged between 6 and 16 years of age, accompanied in pediatric oncology sectors of public health services in the cities of Campina Grande-PB and Natal-RN. The study included 52 children, 13 of these being children and adolescents diagnosed with leukemia and 39 healthy children matched in relation to the study group considering gender, age, school type and level of maternal education. Later the group of children with leukemia was subdivided into two subgroups depending on treatment modality which were submitted: Group 1A (only chemotherapy) and 1B (chemotherapy and radiotherapy). All participants were subjected to a battery of neuropsychological tests that investigated the following neurocognitive abilities: intellectual ability, memory system, attention, visuospatiality and visuoconstruction, processing speed and executive functions. Data were analyzed using descriptive and inferential measurements with the aid of the U test of Mann-Whitney and T test, considering the influence of the variables: sex, age at diagnosis, time since completion of treatment and level of schooling mothers, on the performance of children. Overall, it is concluded that the illness and the treatment of acute lymphoblastic leukemia significantly favors the emergence of cognitive deficits, particularly in terms of visuospatial skills, and executive skills visoconstrutivas. In turn, the treatment modality of radiotherapy is associated with the presence of more severe deficits, highlighting the significant impact on the speed of information processing. It is hoped that the results presented here will contribute to a better understanding of the nature and extent of neurocognitive effects arising ALL treatment

Instituciones de albeytería, y examen de practicantes en élla : divididas en seis tratados, en las que se esplican [sic] las materias mas esenciales para sus profesores /

Mode of access: Internet.

Instituciones de albeytería, y examen de practicantes en élla : divididas en seis tratados, en las que se explican las materias mas esenciales para sus profesores /

Mode of access: Internet.

Instituciones de albeytería, y examen de practicantes en élla : divididas en seis tratados, en las que se explican las materias mas esenciales para sus profesores /

Mode of access: Internet.

Instituciones de albeytería, y examen de practicantes de élla : divididas en seis tratados, en los que se explican las materias mas esenciales para sus profesores /

Texto a dos col.

Instituciones de albeytería, y examen de practicantes en élla : divididas en seis tratados, en los que se explican las materias mas esenciales para sus professores /

Mode of access: Internet.

Instituciones de albeytería, y examen de practicantes en élla : divididas en seis tratados, en los que se explican las materias mas esenciales para sus profesores /

Viñeta decor. xil. en pot.

Cartilla real teórica-práctica, segun leyes reales de Castilla, para escribanos, notarios y procuradores... : añadida al fin de élla las reglas para los jueces de residencia, escribanos, alcaldes, regidores y demas inclusos en éllas /

Contiene: T. III (VIII, 323 p.)