Provisional agenda. Second meeting of the focal points appointed by the Governments of the signatory countries of the Declaration on the application of Principle 10 of the Rio Declaration on Environment and Development in Latin America and the Caribbean

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Report of the second meeting of the focal points appointed by the governments of the signatory countries of the declaration on the application of principle 10 of the Rio Declaration on Environment and Development in Latin America and the Caribbean, Guadalajara, Mexico, 16 and 17 April 2013

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Efectos en El Salvador de las lluvias torrenciales, tormenta tropical Stan y erupción del volcán Ilamatepec (Santa Ana), octubre del 2005

Incluye Bibliografía

Efectos en Guatemala de las lluvias torrenciales y la tormenta tropical Stan, octubre 2005

Incluye Bibliografía

Los medios de comunicación social y su incidencia en el desarrollo local en el canton y Provincia de Zamorra Chinchipe - Ecuador

Analisa a diversidade de formas dos sistemas de comunicação em Zamora - no Equador, os relacionamentos da instituição, participação social e mídias sociais a partir da produção e emissão radiofônica, televisão, comunicação impressa (escrita) e a presença das novas tecnologias na comunicação, tentando achar espaços dos quais seja possível desenvolver práticas alternativas e democráticas para contribuir com o desenvolvimento social. Examina as práticas de comunicação radiofônica, sendo um dos meios principais e com maior tradição na área. Estuda o rádio, particularmente local, analisando seus modelos e programações, observando em cada um deles suas características, objetivos e estratégias assumidas desde sua visão comercial ou ideológica, seu nível profissional e inovação técnica, prestando atenção e nomeando valor à posição critica dos ouvintes, para interpretar as tendências atuais e futuras que se apresentam para eles.Finalmente, chegou-se à comunicação no contexto, examinando os usos e formas, como também a influencia positiva ou negativa na formação da identidade, harmonia com o ambiente, valores e conhecimento em perspectiva de melhorar a qualidade da vida da população. A investigação apóia-se no conhecimento cientifico, pois aplica a técnica qualitativa: Diversidade de grupos focais, entrevistas, observação e uso de investigação bibliográfica.O trabalho considera a historia, a dinâmica própria e a estima que tem os Zamoranos da percepção de sua identificação no contexto de códigos, idiomas e bens, postura desde a qual eles estabelecem normas que devem ser usadas para o seu uso, enquanto permitem articular pontos de vista, analise e conceitos, examinar a teoria para entender o papel que melhor desempenham as mídias sociais e sua importância na sociedade.

TNF alpha contributes for attenuating both Y(397)FAK and Y(416)Src phosphorylations in osteoblasts

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

De Hiel y de Miel di Patxi Zubizarreta. Proposta di traduzione dallo spagnolo all'italiano

Selim, a 15 year-old boy, lives with the desire to leave Morocco in order to get to Europe, and more precisely to Paris, land of dreams and opportunities. However, unfortunately, Selim will face himself with a hostile and dangerous world and the future awaiting for him will be very different from the one he had always imagined for himself. During his journey, he will go through both positive and negative experiences: he will fall in love with Esther, a Spanish girl from Vitoria, but he will also discover the harshness of the Western world. This paper provides a translation of the Spanish novel De hiel y de miel, written by the Basque author Patxi Zubizarreta and first published in Spain in 1995. In the first chapter, we find the presentation of the author and his book, including a detailed analysis of the main features of the novel. The second chapter is the focal point of the paper as it presents a translation of the novel. Finally, the third and last chapter focuses on the problems that arose during the translation process and how these were solved by the translator.

LGI2 truncation causes a remitting focal epilepsy in dogs

One quadrillion synapses are laid in the first two years of postnatal construction of the human brain, which are then pruned until age 10 to 500 trillion synapses composing the final network. Genetic epilepsies are the most common neurological diseases with onset during pruning, affecting 0.5% of 2-10-year-old children, and these epilepsies are often characterized by spontaneous remission. We previously described a remitting epilepsy in the Lagotto romagnolo canine breed. Here, we identify the gene defect and affected neurochemical pathway. We reconstructed a large Lagotto pedigree of around 34 affected animals. Using genome-wide association in 11 discordant sib-pairs from this pedigree, we mapped the disease locus to a 1.7 Mb region of homozygosity in chromosome 3 where we identified a protein-truncating mutation in the Lgi2 gene, a homologue of the human epilepsy gene LGI1. We show that LGI2, like LGI1, is neuronally secreted and acts on metalloproteinase-lacking members of the ADAM family of neuronal receptors, which function in synapse remodeling, and that LGI2 truncation, like LGI1 truncations, prevents secretion and ADAM interaction. The resulting epilepsy onsets at around seven weeks (equivalent to human two years), and remits by four months (human eight years), versus onset after age eight in the majority of human patients with LGI1 mutations. Finally, we show that Lgi2 is expressed highly in the immediate post-natal period until halfway through pruning, unlike Lgi1, which is expressed in the latter part of pruning and beyond. LGI2 acts at least in part through the same ADAM receptors as LGI1, but earlier, ensuring electrical stability (absence of epilepsy) during pruning years, preceding this same function performed by LGI1 in later years. LGI2 should be considered a candidate gene for common remitting childhood epilepsies, and LGI2-to-LGI1 transition for mechanisms of childhood epilepsy remission.