Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.

Most models of tumorigenesis assume that the tumor grows by increased cell division. In these models, it is generally supposed that daughter cells behave as do their parents, and cell numbers have clear potential for exponential growth. We have constructed simple mathematical models of tumorigenesis through failure of programmed cell death (PCD) or differentiation. These models do not assume that descendant cells behave as their parents do. The models predict that exponential growth in cell numbers does sometimes occur, usually when stem cells fail to die or differentiate. At other times, exponential growth does not occur: instead, the number of cells in the population reaches a new, higher equilibrium. This behavior is predicted when fully differentiated cells fail to undergo PCD. When cells of intermediate differentiation fail to die or to differentiate further, the values of growth parameters determine whether growth is exponential or leads to a new equilibrium. The predictions of the model are sensitive to small differences in growth parameters. Failure of PCD and differentiation, leading to a new equilibrium number of cells, may explain many aspects of tumor behavior--for example, early premalignant lesions such as cervical intraepithelial neoplasia, the fact that some tumors very rarely become malignant, the observation of plateaux in the growth of some solid tumors, and, finally, long lag phases of growth until mutations arise that eventually result in exponential growth.

Proceedings of the Second American-Soviet Symposium on the Use of Mathematical Models to Optimize Water Quality Management, Bloomfield Hills, Michigan, USA, August 27-30, 1979 /

Mode of access: Internet.

Mathematical models in the social sciences

Mode of access: Internet.

Improvement of mathematical models for simulation of vehicle handling. Volume 6: programmers' guide for the driver module. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for vehicle handling. Volume 7: technical manual for the general simulation. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for vehicle handling. Volume 8: summary report. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for simulation of vehicle handling. Volume 1: user's guide for the five degree of freedom models. Final report.

Mode of access: Internet.

Improvement of mathematical models for simulation of vehicle handling. Volume 2: programmers' guide for the five degree of freedom models. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for vehicle handling. Volume 3: technical manual for the five-degree-of-freedom models. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for vehicle handling. Volume 4: users'guide for the general simulation. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for simulation of vehicle handling. Volume 5: programmers' guide for the vehicle model. Part I: documentation through subroutine IOUT. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for simulation of vehicle handling. Volume 5: programmers' guide for the vehicle model. Part 2: documentation for subroutines PRTDIC through KNMTC. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Improvement of mathematical models for simulation of vehicle handling. Volume 5: programmers' guide for the vehicle model. Part 3: documentation for subroutines SLPCLC through OUTPUT and a double precision listing. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Applicability of two mathematical models to the batch settling of activated sludge.

"Supported by Federal Water Pollution Control Administration, U.S. Department of the Interior. Research project WP-01011."

Regional adjustments in grain production : a linear programming analysis : mathematical models, proofs, methods of data collection and estimation, and supplementary tables /

Cover title.