Toxicity and dose intensity of FOLFOX in patients with increased body mass index

This study was conducted at St James‘s Hospital, Dublin, Ireland, in 2010. It evaluated the dose intensity and toxicities experienced by patients of normal and increased body mass index treated with FOLFOX chemotherapy, and demonstrated that overweight patients may tolerate doses based on actual body weight.

A framework for understanding collaborative creativity in requirements engineering: Empirical validation

Requirements engineering (RE) often needs creativity in a form where interactions among stakeholders are particularly important: collaborative creativity. However, few studies have explicitly concentrated on understanding collaborative creativity in RE, resulting in a lack of well-founded advice for practitioners on how to support this aspect of RE. Through an online survey, this paper seeks empirical validation for a framework of factors characterising collaborative creative processes in RE. Within the limits of the validity of the study, the results show support for the utility of the framework: collaborative creativity seems to be a linear function of the mean score to all factors in the framework. Factors can be grouped, and the specific impact of each group on collaboration, value and novelty can be assessed.

Standardised packaging and new enlarged graphic health warnings for tobacco products in Australia--legislative requirements and implementation of the Tobacco Plain Packaging Act 2011 and the Competition and Consumer (Tobacco) Information Standard, 2011

This paper describes the development, content and implementation of two pieces of Australian tobacco control legislation: one to standardise the packaging of tobacco products and the other to introduce new, enlarged graphic health warnings. It describes the process of legislative drafting, public consultation and parliamentary consideration. It summarises exactly how tobacco products have been required to look since late 2012. Finally, it describes implementation, most particularly, the extent to which packs compliant with the legislation became available to consumers over time.

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people : protocol for the ASPREE-Fracture substudy

Background Disability, mortality and healthcare burden from fractures in older people is a growing problem worldwide. Observational studies suggest that aspirin may reduce fracture risk. While these studies provide room for optimism, randomised controlled trials are needed. This paper describes the rationale and design of the ASPirin in Reducing Events in the Elderly (ASPREE)-Fracture substudy, which aims to determine whether daily low-dose aspirin decreases fracture risk in healthy older people. Methods ASPREE is a double-blind, randomised, placebo-controlled primary prevention trial designed to assess whether daily active treatment using low-dose aspirin extends the duration of disability-free and dementia-free life in 19 000 healthy older people recruited from Australian and US community settings. This substudy extends the ASPREE trial data collection to determine the effect of daily low-dose aspirin on fracture and fall-related hospital presentation risk in the 16 500 ASPREE participants aged ≥70 years recruited in Australia. The intervention is a once daily dose of enteric-coated aspirin (100 mg) versus a matching placebo, randomised on a 1:1 basis. The primary outcome for this substudy is the occurrence of any fracture-vertebral, hip and non-vert-non-hip-occurring post randomisation. Fall-related hospital presentations are a secondary outcome. Discussion This substudy will determine whether a widely available, simple and inexpensive health intervention-aspirin-reduces the risk of fractures in older Australians. If it is demonstrated to safely reduce the risk of fractures and serious falls, it is possible that aspirin might provide a means of fracture prevention.

Growth-rate associated changes in the energy-requirements of tern chicks

To obtain infonnation on the energetic implications of intraspecific growth rate differences we measured the energy requirement for development in chicks of Common Tern Sterna hirundo and Sandwich Tern S. sandvicensis under laboratory conditions. Both maximum (kJ.day-l) and total gross energy intake for development (kJ during prefledging period) increased with growth rate and were reduced by almost 40% and 25%, respectively, in the slowest compared to the fastest growing individuals in each of the two species. These results imply that the range of food availability within which a chick can grow to adulthood, is wider than hitherto believed. However, one should bear in mind that slow growth also may result in higher nestling and postfledging mortality.

Energetic requirements for maintenance and premigratory body mass gain of waders wintering in Africa

The energy content of the deposited reserve tissue depended on the condition of the birds, since the energy required for body mass gain was low in lean birds and high in fat birds. Maintenance metabolism was relatively low compared to wader species wintering in temperate regions, suggested to be an adaptation towards reduced endogenous heat production, which may help in avoiding heat stress under tropical conditions. -from Authors

Collaborative creativity in requirements engineering: analysis and practical advice

Requirements engineering (RE) often entails interdisciplinary groups of people working together to find novel and valuable solutions to a complex design problem. In such situations RE requires creativity in a form where interactions among stakeholders are particularly important: collaborative creativity. However, few studies have explicitly concentrated on understanding collaborative creativity in RE, resulting in limited advice for practitioners on how to support this aspect of RE. This paper provides a framework of factors characterising collaborative creative processes in RE. These factors enable a systematic investigation of the collaboratively creative nature of RE. They can potentially guide practitioners when facilitating RE efforts, and also provide researchers with ideas on where to focus when developing methods and tools for RE. © 2013 IEEE.

Ownership structure and collateral requirements: Evidence from China’s listed firms

This paper examines the effect of ownership structure on collateral requirements using a sample of China's listed firms from 2007 to 2009. We find that compared to privately controlled companies, state-controlled companies are less likely to be required to pledge collateral, and such a difference is more pronounced for firms in troubled industries. The empirical results also show that the effect of state control on collateral requirements is weaker in companies with more foreign ownership. Moreover, the effect of state control on collateral requirements is weaker in companies with more third party guarantees. Finally, we find that the effect of state control on collateral requirements is more pronounced for firms operating in regions with more government intervention.

Protein requirements and recommendations for older people: a review

Declines in skeletal muscle mass and strength are major contributors to increased mortality, morbidity and reduced quality of life in older people. Recommended Dietary Allowances/Intakes have failed to adequately consider the protein requirements of the elderly with respect to function. The aim of this paper was to review definitions of optimal protein status and the evidence base for optimal dietary protein. Current recommended protein intakes for older people do not account for the compensatory loss of muscle mass that occurs on lower protein intakes. Older people have lower rates of protein synthesis and whole-body proteolysis in response to an anabolic stimulus (food or resistance exercise). Recommendations for the level of adequate dietary intake of protein for older people should be informed by evidence derived from functional outcomes. Randomized controlled trials report a clear benefit of increased dietary protein on lean mass gain and leg strength, particularly when combined with resistance exercise. There is good consistent evidence (level III-2 to IV) that consumption of 1.0 to 1.3 g/kg/day dietary protein combined with twice-weekly progressive resistance exercise reduces age-related muscle mass loss. Older people appear to require 1.0 to 1.3 g/kg/day dietary protein to optimize physical function, particularly whilst undertaking resistance exercise recommendations.

Considering the chemical energy requirements of the tri-n-propylamine co-reactant pathways for the judicious design of new electrogenerated chemiluminescence detection systems

The introduction of a 'co-reactant' was a critical step in the evolution of electrogenerated chemiluminescence (ECL) from a laboratory curiosity to a widely utilised detection system. In conjunction with a suitable electrochemiluminophore, the co-reactant enables generation of both the oxidised and reduced precursors to the emitting species at a single electrode potential, under the aqueous conditions required for most analytical applications. The most commonly used co-reactant is tri-n-propylamine (TPrA), which was developed for the classic tris(2,2'-bipyridine)ruthenium(ii) ECL reagent. New electrochemiluminophores such as cyclometalated iridium(iii) complexes are also evaluated with this co-reactant. However, attaining the excited states in these systems can require much greater energy than that of tris(2,2'-bipyridine)ruthenium(ii), which has implications for the co-reactant reaction pathways. In this tutorial review, we describe a simple graphical approach to characterise the energetically feasible ECL pathways with TPrA, as a useful tool for the development of new ECL detection systems.

KBRE: a framework for knowledge-based requirements engineering

Detecting inconsistencies is a critical part of requirements engineering (RE) and has been a topic of interest for several decades. Domain knowledge and semantics of requirements not only play important roles in elaborating requirements but are also a crucial way to detect conflicts among them. In this paper, we present a novel knowledge-based RE framework (KBRE) in which domain knowledge and semantics of requirements are central to elaboration, structuring, and management of captured requirements. Moreover, we also show how they facilitate the identification of requirements inconsistencies and other-related problems. In our KBRE model, description logic (DL) is used as the fundamental logical system for requirements analysis and reasoning. In addition, the application of DL in the form of Manchester OWL Syntax brings simplicity to the formalization of requirements while preserving sufficient expressive power. A tool has been developed and applied to an industrial use case to validate our approach.

A pair-oriented requirements engineering approach for analysing multi-lingual requirements

Requirements written in multiple languages can lead to error-proneness, inconsistency and incorrectness. In a Malaysian setting, software engineers are exposed to both Malay and English requirements. This can be a challenging task for them especially when capturing and analyzing requirements. Further, they face difficulties to model requirements using semi-formal or formal models. This paper introduces a new approach, Pair-Oriented Requirements Engineering (PORE) that uses an Essential Use Case (EUC) model to capture and analyze multi-lingual requirements. This approach is intended to assist practitioners in developing correct and consistent requirements as well as developing teamwork skills. Two quasi-experiment studies involving 80 participants in the first study and 38 participants in a subsequent study were conducted to evaluate the effectiveness of this approach with respect to correctness and time spent in capturing multi-lingual requirements. It was found that PORE improves accuracy and hence helps users perform better in developing high quality requirements models.

Capturing security requirements using essential use cases (EUCs)

Capturing security requirements is a complex process, but it is crucial to the success of a secure software product. Hence, requirements engineers need to have security knowledge when eliciting and analyzing the security requirements from business requirements. However, the majority of requirements engineers lack such knowledge and skills, and they face difficulties to capture and understand many security terms and issues. This results in capturing inaccurate, inconsistent and incomplete security requirements that in turn may lead to insecure software systems. In this paper, we describe a new approach of capturing security requirements using an extended Essential Use Cases (EUCs) model. This approach enhances the process of capturing and analyzing security requirements to produce accurate and complete requirements. We have evaluated our prototype tool using usability testing and assessment of the quality of our generated EUC security patterns by security engineering experts.

GUITAR: An ontology-based automated requirements analysis tool

Combining goal-oriented and use case modeling has been proven to be an effective method in requirements elicitation and elaboration. However, current requirements engineering approaches generally lack reliable support for automated analysis of such modeled artifacts. To address this problem, we have developed GUITAR, a tool which delivers automated detection of incorrectness, incompleteness and inconsistency between artifacts. GUITAR is based on our goal-use case integration meta-model and ontologies of domain knowledge and semantics. GUITAR also provides comprehensive explanations for detected problems and can suggest resolution alternatives.