La transición epidemiológica en América Latina

Incluye Bibliografía

Paraguay, efectos demograficos de la evolucion de la mortalidad por causas en el periodo 1970-1980

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Situacion demografica de la Provincia de Atacama, 1970: trabajo final de investigacion

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Assignment of Putative Functions to Membrane "Hypothetical Proteins" from the Trypanosoma cruzi Genome

Protozoan parasites cause thousands of deaths each year in developing countries. The genome projects of these parasites opened a new era in the identification of therapeutic targets. However, the putative function could be predicted for fewer than half of the protein-coding genes. In this work, all Trypanosoma cruzi proteins containing predicted transmembrane spans were processed through an automated computational routine and further analyzed in order to assign the most probable function. The analysis consisted of dissecting the whole predicted protein in different regions. More than 5,000 sequences were processed, and the predicted biological functions were grouped into 19 categories according to the hits obtained after analysis. One focus of interest, due to the scarce information available on trypanosomatids, is the proteins involved in signal-transduction processes. In the present work, we identified 54 proteins belonging to this group, which were individually analyzed. The results show that by means of a simple pipeline it was possible to attribute probable functions to sequences annotated as coding for "hypothetical proteins.'' Also, we successfully identified the majority of candidates participating in the signal-transduction pathways in T. cruzi.

On the Evolution of Hexose Transporters in Kinetoplastid Potozoans

Glucose, an almost universally used energy and carbon source, is processed through several well-known metabolic pathways, primarily glycolysis. Glucose uptake is considered to be the first step in glycolysis. In kinetoplastids, a protozoan group that includes relevant human pathogens, the importance of glucose uptake in different phases of the life cycles is well established, and hexose transporters have been proposed as targets for therapeutic drugs. However, little is known about the evolutionary history of these hexose transporters. Hexose transporters contain an intracellular N- and C-termini, and 12 transmembrane spans connected by alternate intracellular and extracellular loops. In the present work we tested the hypothesis that the evolutionary rate of the transmembrane span is different from that of the whole sequence and that it is possible to define evolutionary units inside the sequence. The phylogeny of whole molecules was compared to that of their transmembrane spans and the loops connecting the transmembrane spans. We show that the evolutionary units in these proteins primarily consist of clustered rather than individual transmembrane spans. These analyses demonstrate that there are evolutionary constraints on the organization of these proteins; more specifically, the order of the transmembrane spans along the protein is highly conserved. Finally, we defined a signature sequence for the identification of kinetoplastid hexose transporters.

Protocolo de tecnologia: selecao para resistencia a doencas em hortalicas. 1. Etapas para selecao de fontes de resistencia a doencas.

1999

Protocolo de tecnologia: selecao para resistencia a doencas em hortalicas. 2. Tomateiro - Mancha-de-estenfilio (Stemphylium spp.).

1999

Protocolo de tecnologia: selecao para resistencia a doencas em hortalicas. 3. Tomateiro - Murcha-de-fusario (Fusarium oxysporum f.sp. lycopersici).

1999

Protocolo de tecnologia: selecao para resistencia a doencas em hortalicas. 4. Tomateiro - Murcha-de-verticilio (Verticillium dahliae e V. albo-atrum).

1999

Protocolo de tecnologia: selecao para resistencia a doencas em hortalicas. 5. Tomateiro - Pinta-preta (Alternaria solani).

1999

Protocolo de tecnologia: selecao para resistencia a doencas em hortalicas. 6. Tomateiro - Septoriose (Septoria lycopersici).

1999

Inoculacao de bacterias endofiticas em milho para o controle de doencas fungicas.

2001

Doencas da bananeira no Estado do Amazonas.

Informacoes sobre doencas, foliares, vasculares e abiotica, da bananeira no Estado do Amazonas, e seu controle.

Análisis de las comunidades parasitarias y su relación con la condición física del guajolote silvestre (Meleagris gallopavo) de la Sierra del Burro, Coah., México

Tesis (Maestría en Ciencias con Especialidad en Parasitología) UANL

Monitoreo y distribución de infecciones bacterianas y parasitarias en el cultivo de bagre ictalurus punctatus en Tamaulipas.

Tesis (Doctor en Ciencias con Acentuación en Microbiología) UANL, 2010.