Etiologia, perfil de sensibilidade aos antimicrobianos e aspectos epidemiológicos na otite canina: estudo retrospectivo de 616 casos

A retrospective study of etiology, antimicrobial susceptibility profile and multiple drug resistance, and major epidemiological aspects were investigated in 616 cases of canine otitis. Staphylococcus beta hemolitic (26.27%), Malassezia pachydermatis (12.35%), and Pseudomonas aeruginosa (8.8%) were the most common microorganisms identified. The isolates were susceptible mainly to norfloxacin (89.62%), gentamicin (83.25%), and ofloxacin (80.16%). High occurrence of resistance of isolates was observed to neomicin (30.84%) and cephalexin (27.63%). Multiple drug resistance to three or more and five or more of antimicrobials tested was observed in 34.9% and 15.5% of isolates, respectively. The cases of canine otitis occurred predominantly in first years of age, in mixed breeds animals, at autumn season. The presence of itch, bad smell, and secretion in ear conduct were the major signs observed at clinical examination.

Resolución 616(XXXI): Población y desarrollo: actividades prioritarias para el período 2006-2008

Error en símbolo en tapa y contraportada (S/2006/20)

Resolution 616(XXXI): Population and development: priority activities for the period 2006-2008

Includes bibliography

Worte gesprochen am Grabe des verewigten Freiherrn Amschel Mayer von Rothschild : Sonntag den 9. December 1855 ; 29. Kislev 616

von S. R. Hirsch

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 616 - Wiederholte Ablehnung der Verlegung der "Gemischten Philosophischen Schriften"

u.a.: Vorgeschlagene Eigenfinanzierung;

Ms.Ff.F.Stoltze 3. 616 - Brief von Marie Stoltze an Friedrich Stoltze

Friedrich Stoltze II

Na 1 Nachlass Max Horkheimer, 616 - Vorbereitungsunterlagen zu "Materialismus", "Geschichtsphilosophie" und anderen Themen (p. VIII 15-VIII 20.2)

"Über Lenin, 'Materialismus und Empiriokritizismus" (GS 11, S. 171-188), Wintersemester 1928/29, a) Typoskript, 17 Blatt, b) Typoskript mit eigenhändigen Korrekturen, 17 Blatt (unterzeichnet mit "H. Möller (Berlin)", c) Manuskript, 1 Heft, 18 Blatt, davon 3 leer, d) Entwurf, Typoskript mit eigenhändigen Korrekturen, 11 Blatt; Friedrich Pollock: Kollegheft zum Seminar von Max Horkheimer über Geschichtsphilosophie, Wintersemester 1928/29 (enthält: Kollegheft 23.11.1928 - 15.02.1929, eigenhändige Notizen, 1 Heft, 16 Blatt und 4 zusätzliche Blätter; Kolegheft 22.02.1929, eigenhändige Notizen, 1 Heft, 16 Blatt, davon 9 leer); Friedrich Pollock: Notizen zu einem Vortrag von Hans Cornelius über 'Klassenphilosophie und reine Philosophie', und Mitschrift von Diskussionsbeiträgen , u.a. von Max Horkheimer, 26.01.1929, eigenhändige Notizen, 1 Heft, 12 Blatt und 1 zusätzliches Blatt sowie eigenhändige Notizen von Max Horkheimer; "Kant und die Philosophie der Gegenwart", Vorlesung 1929 (enthält: Vorlesungsmanuskript und Friedrich Pollock: Kolleghefte zur Vorlesung, eigenhändige Notizen); "Hegel", Übung Sommersemester 1929 (enthält: 1 Notizheft, 28 Blatt mit eigenhändigen Notizen zur Übung, 5 Blatt und eigenhändigen Notizen über Vorgeschichte und Anfänge der Soziologie, 5 Blatt; Friedrich Pollock: eigenhändige Notizen zur Übung von Max Horkheimer, 1 Heft, 28 Blatt, davon 4 leer, und 3 zusätzliche Blätter); "Wissensoziologie oder Historischer Materialismus" Einleitung: Soziologie der Soziologie" (GS 11, S. 189-195), Wintersemester 1929/30 (enthält: Manuskript, teils von Max Horkheimer, teils von Friedrich Polock, datiert: 10.09.1929, 1 Heft, 10 Blatt und 2 zusätzliche Blätter; Manuskript, datiert Wintersemester 1929/30, 1 Heft, 4 Blatt, davon 1 leer);

ALLERGEN SENSITIZATION AND IMMUNOMODULATION BY SYNTHETIC LIGANDS, PUL-042, IN AN ALLERGEN-INDUCED ASTHMA MURINE MODEL

Allergen-induced asthma is the leading form of asthma and a chronic condition worldwide. Common allergens are known to contribute to the pathogenesis of this disease. Murine models of allergic asthma have mostly used an intraperitoneal route of sensitization (not airway) to study this disease. Allergic asthma pathophysiology involves the activation of TH2-specific cells, which triggers production of IgE antibodies, the up-regulation of TH2-specific cytokines (i.e. IL-4, IL-5, IL-9 and IL-13), increased airway eosinophilia, and mucin hypersecretion. Although there are several therapeutics currently treating asthmatic patients, some of these treatments can result in drug tolerance and may be linked to increased mortality. CpG oligodeoxynucleotides (ODNs) is a synthetic ligand that targets Toll-like Receptor (TLR) 9. It has been evaluated as a therapeutic agent for the treatment of cancer, infectious diseases, and for treating allergy and asthma. PUL-042 is also a synthetic TLR ligand and is composed of two agonists against TLR2/6 heterodimer and TLR9. Previous studies have evaluated PUL-042 for its ability to confer resistance against bacterial and viral lung infection. These findings, combined with studies performed using CpG ODNs, led to speculation that PUL-042 dampens the immune response in allergen-induced asthma. My thesis research investigated airway route sensitization and airway delivery of PUL-042 to evaluate its effects in reducing an allergen-induced asthma phenotype in a murine model. The results of this study contribute to the foundation for future investigations to evaluate the efficacy of PUL-042 as a novel therapy in allergic-asthma disease.

A.A.V.V.: Reason, morality, and law. The philosophy of John Finnis, J. Keown & R.P. George (eds.), Oxford, Oxford University Press, 2013, 616 pp.

Fil: Massini Correas, Carlos I.. Universidad de Mendoza