Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Determinação da relação de novo biomarcador (IMP3) no carcinoma de nasofaringe

Pós-graduação em Patologia - FMB

Linfoma de Hodgkin: características anátomo-clínicas e análise de novo biomarcador (IMP3)

Pós-graduação em Patologia - FMB

Sarcoma histiocítico: análise molecular pela técnica de hibridação genômica comparativa, microRNA e imunoistoquímica

Pós-graduação em Patologia - FMB

Linfomas Double-Hit em casuística de Linfomas Não-Hodgkin B de alto grau: estudo clínico, morfológico, imunoistoquímico e citogenético

Pós-graduação em Patologia - FMB

Uso da radioterapia no tumor venéreo transmissível em cães

Since the discovery of x rays, the use of radiation in oncology has advanced remarkably. In Brazil, radiation therapy in animals is limited to some isolated studies in public universities and the procedures performed is still precarious because radiation equipments are expensive and there is still a lack of skilled professionals. The transmissible venereal tumor (TVT) is a contagious neoplasm of spontaneous occurrence, commonly treated with vincristine. This paper describes the positive experience of radiotherapy as an isolated option or as an combined treatment with vincristine in three cases of TVT. It was observed that radiotherapy may be used in routine clinical chemotherapy alone or combined with chemotherapy since suitable sources of radiation are provided.

Carcinoma de células escamosas em assoalho vaginal de um bovino nelore associado a metástase em pulmão: relato de caso

The squamous cell carcinoma (SCC) is a neoplasm that affect pets and production animals and it’s very common in tropical countries like Brazil; develops in sparsely pigmented, stratified squamous epithelium and in mucosal surfaces exposed Ultraviolet action. The SCC is quite infiltrative but rarely causes metastases. Its occurrence in the female reproductive tract is recognized in the literature on cattle breeds from Europe. This case was a female bovine, Nelore, adult, who was referred to the "Hospital Veterinário Luiz Quintiliano de Oliveira" with dark brown fluid leakage and putrid odor, associated with ulcerative growth of the vagina. Because the extent of injury, the animal was euthanized and taken to the necropsy, which was observed on board structure, ulcerated and pus in the vaginal floor, infiltrated into the pelvic cavity to the serosa of the uterine body. The microscopic findings were detected neoplastic proliferation of epithelial cells in the floor and vaginal metastases in the lung parenchyma, and classified the primary tumor and metastasis as squamous cell carcinoma moderately differentiated.

Detection of the tumour suppressor gene TP53 and expression of p53, Bcl-2 and p63 proteins in canine transmissible venereal tumour

Canine transmissible venereal tumour (CTVT) is a neoplasm transmitted among healthy dogs by direct contact with injured skin and/or mucous tissue. This study aimed to identify the TP53 gene, messenger RNA (mRNA) as well as the expression of p53, Bcl-2 and p63 proteins in histological sections of 13 CTVT samples at different stages of evolution. The in situ hybridization (ISH) and in situ reverse transcriptase polymerase chain reaction (RT-PCR) assays were used, which showed the DNA homologous to TP53 and its respective mRNA in 92.3% of the samples. We detected p53, p63 and Bcl-2 proteins in most of the cell samples in different grades of intensity. In addition, 46% of the samples were in the progressive and 54% in the regression phase. This is the first description of these proteins and a detailed study of their role in CTVT cells needs to be addressed in or to verify how these cells undergo apoptosis.

Tumor odontogênico queratocístico e considerações diagnósticas

Keratocystic odontogenic tumor (KCOT is benign, featuring controversies in diagnosis and treatment. It occurs mainly in the region of the mandibular angle, which may or may not be related to a tooth and whose importance is due to its aggressive behavior and high recurrence rate. The causes of high rates of relapse observed in this lesion are dependent on factors such as age, location and size of lesion, gender, type of treatment and histological variant. The thin capsule and friable connective tissue of KCOT may favor the retention of epithelial debris responsible for the high proliferative capacity of this clinical entity. Due to the aggressiveness with its recurrence this paper aims to conduct a literature review addressing clinical and imaging aspects, composes the histopathological diagnosis of KCOT.

Cisto dermóide em assoalho bucal: 2 casos clínicos

Dermoid cyst of the floor of the mouth is an uncommon lesion that presents as a solitary mass, painless, with no history of fever or drainage, usually in the midline, and commonly in the upper level space mylohyoid. In this paper, the authors describe two patients with the same clinical presentation: a large mass in the floor of the mouth that does not regressed, resulting in dysphagia and dyspnea. The treatment was carried out in both complete surgical removal through an incision in the ventral surface of the tongue.

O tabaco é um dos principais fatores etiológicos do câncer bucal: conceitos atuais

Neoplasm, tumor or cancer generic synonymies are used to designate a group of diseases that affect any part of the body.Their main common feature is the abnormal cell proliferation, usually rapid, uncontrolled and unrestrained. According to World HealthOrganization (WHO) cancer is the leading cause of death worldwide. In 2005, a total of 58 million deaths, 7.6 million (or 13%) of all of them were cancer. Among the factors that favor its development, the tobacco is considered one of the main villains. Therefore, this article, we will discuss the basics and updates about oral cancer and tobacco consumption.

Carcinoma de células escamosas em epitélio nasal de um hamster chinês: relato de caso

The squamous cell carcinoma (SCC) is a neoplasm that affect pets, production animals and exotic animals, and it’s very common in tropical countries like Brazil, once it develops a sparsely pigmented, stratified squamous epithelium and on surfaces mucosa exposed to ultraviolet action. The SCC is quite infiltrative but rarely causes metastases. Its occurrence in the nasal epithelium is widely reported in cats. This case is a chinese hamster (Cricetulus griséus), female, young, who developed a nasal nodule, and their only clinical sign was intense itching. The animal underwent surgery to perform an incisional biopsy, which was referred to the Veterinary Pathology Service of UNESP, campus of Araçatuba (SP) for histopathological evaluation. The material showed features consistent with squamous cell carcinoma well differentiated.

Tumor odontogênico de células granulares

Introduction: the granular cell odontogenic tumors are an uncommon neoplasm with benign clinical behavior. The lesion occurs over a wide age range with a typically predilection for the mandibular canine and molar regions. Aim: present a granular cell odontogenic tumor literature review. Conclusions: the tumor don’t present an aggressive biological behavior although recurrences can occur. The lesion is treated by conservative surgery with curettage and enucleation as election procedures.

Influência das células mioepiteliais neoplásicas benignas de adenoma pleomórfico na produção de MMPs -1, -2, - 8, -9 e -13 por células epiteliais malignas e sua possível relação com o índice de invasão

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Ureterostomias cutânea e colônica em suínos: avaliação da exequibilidade das técnicas e complicações pós-operatórias

Pós-graduação em Medicina Veterinária - FCAV