Phase II clinical study of an association for the treatment of interstitial cystitis (CYSTEX)

Painful bladder syndrome associated with interstitial cystitis (PBS/IC) is a clinical condition characterized pelvic pain, urinary urgency, and urinary frequency. In this study, 22 patients were assigned to make two visits over a three weeks period. The patients were randomly, double-blinded assigned in two groups. The first group received Cystex® capsules. The second group received placebo capsules. Two capsules were taken three times a day away from meals. The change from baseline in the O’Leary-Sant IC symptom and problem index was the primary outcome parameter. Changes in functional bladder capacity and intensity of pain and urgency have been chosen as secondary outcome parameters. Mood as well as physical and sexual activity were rated by 10 questions on a scale 0 to 6. The ratings were analyzed and the average for each patient in both groups Cystex® and placebo was determined as the quality of life index. For the primary outcome there was a statistically significant difference between the groups. Mean symptom score-sum decreased from 28.4 to 20.5 in the Cystex® group compared with 29.5 to 26.8 in the placebo group (p<0.05). For the secondary end points, pain and urgency intensity improved statistically significantly in the Cystex® group compared with the placebo group (p<0.05). The frequency and functional bladder capacity improved to greater degree in the Cystex® group. The differences were statistically significant for comparison of frequency (p<0.05) and not for functional bladder capacity (p>0.05). In our study, Cystex® enhanced quality of life over the placebo showing a statistically significant. This trial have shown that the efficacy and safety of therapy with Cystex® in the treatment of interstitial cystitis and is an alternative for patients suffering from this pathology. Therefore, it can be concluded that the composition of Cystex®, increased the quality of life in treated patients.

Double-Blind clinical study of a multivitamin and polymineral complex associated with Panax ginseng (Gerovital)

The present study aimed to evaluate the efficacy of a multivitamin and poly minerals supplemented with Panax ginseng extract (Gerovital®) on patients suffering from common physical or mental stress. The study design was controlled, parallel and double blind. Patients were randomly divided in two groups and underwent a thorough clinical and laboratory examination. Group A received placebo capsules and group B received Gerovital® capsules. In both cases, two capsules were taken daily during meals for eight weeks. Mood as well as physical activity were evaluated through a questionnaire assessing quality of life. From the 126 patients enrolled, 12 patients (8 in group A and 4 in group B) were excluded due to voluntary withdrawal, 55 patients completed the study in group A and 59 in group B. The treatment with Gerovital® significantly increased the quality of life when compared to placebo. After 15 days of study no difference between groups was observed. However, at 30th, 45th and 60th day, group B showed a statistically significant increase in average score from 30.05 to 41.96, 47.01 and finally 50.81 points. No increase in body weight was detected in either group. No difference in blood pressure or heart rate was also observed between treatments. The present study has shown that the daily use of Gerovital® over a 2-month period can be effective in improving quality of life in patients suffering from physical and mental stress among individuals of different ages, ranging from adults to elderly. Moreover, its use has been associated to a lower incidence of flu-like seasonal respiratory illnesses. Finally, the incidence of undesired effects was similar to placebo.

A construção de movimento com propósito em português

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Atividade física e sintomas depressivos em cuidadores de idosos com demência de Alzheimer

The Alzheimer's dementia (AD) is a chronic, neurodegenerative and progressive disorder, characterized by cognitive decline, affecting brain functions like memory, reasoning and communication, occurrence of behavioral disturbances and difficulty in performing activities of daily living (ADLs). These conditions lead to patient’s dependence, which can cause depressive symptoms in caregivers, due to physical and mental burden caused by of the difficulties of the act of caring. Whereupon, it became necessary to find strategies to improve the caregivers’ quality of life. An interesting hypothesis is that physical activity can be considered a non-pharmacological alternative in reducing depressive symptoms, being an important factor for maintaining the physical and mental well-being of the general population, especially on positive changes in mood and social interaction. This study aimed to analyze the effects of a physical activity protocol on depressive symptoms and burden of caregivers of patients with AD. This experimental study, of longitudinal character, comprised a sample of 19 caregivers, of both genders, divided into two groups: a) intervention group – IG (10 caregivers who participated in a physical activity protocol) and b) control group – CG (9 caregivers who didn’t participate in the physical activity protocol). This protocol, which worked the components of functional ability and social interaction of participants, was held three times a week, being 48 sessions of 60 minutes each, for 16 weeks. Data collect was performed at pre and post-intervention for both groups. The assessment instruments used were: a) Zarit Burden Interview, b) Hospital Anxiety and Depression Scale (HAD) and c) battery of motor tests of the American Alliance for Health Physical Education Recreation and Dance (AAHPERD). Nonparametric statistics was used, with intra-group comparison by Wilcoxon test... (Complete abstract click electronic access below)

Efeito de um programa de ginástica laboral na saúde, estados de ânimo e estresse diário do trabalhador

The practice of regular physical activity has been widely recommended in the literature, indicating an improvement of the physical and psychological activities promoted through the routine of workers. In this sense, physical activity has become of great importance in the workplace, for the prevention of injuries caused by normalizing bodily functions and staff providing relaxation and socialization, basic elements of daily life a worker. This study aimed to analyze the effects of a active break program in the routine of workers in their mood and stress, even checking the influence of physical activity on quality of life of participants. We selected 15 individuals of both genders, the restaurant staff University, UNESP - Rio Claro-SP. The activities lasted four months, two times a week, at the beginning of the workday, for 15 minutes, followed by stretching and playful activity. The evaluations were answered a week before the execution of the program and lists of mood states have been answered before and after the activity, and the end of working hours and also at the beginning and end of the days when there were no interventions. After analyzing the results, we concluded that the participants have a good index of perception of quality of life with total score of 76.6 for mental and physical health and that all assets are considered in accordance with the recommendations of 150 minutes of physical activity per week. More than 50% of them have symptoms of stress found mostly in the resistance stage, and no changes were found in the mood states when practicing active break or not. We conclude that the changing of moods can be associated with the fact that workers are already active, another reason may be due to low number of participants in the study, given other studies show that there is a change and that active break interferes positively in mood states of individuals

A interferência do estado de humor na melhora dos componentes da capacidade funcional em idosos

Mood States are feelings auto regulation deliver to individual better quality of life and healthy aging. The declines of the aging process can be minimized with the regular practice of physical activity and systematized. The objective of this study was to evaluate the effects of a dance program in mood states, depressive symptoms and functional capacity in elderly participants of PROFIT. METHOD: The sample was composed of 20 elderly people. The Training Group was formed by 15 elders who participated in a protocol of dance with duration of 1 hour, three times per week, for 12 weeks and the Control Group, composed of 5 elderly, did not attend any program of physical activity. The participants were evaluated by the List of States of Mind Reduced and Illustrated, Geriatric Depression Scale and the battery of tests of AAHPERD. For the mood states was used non-parametric analysis, according to the technique of Binomial Analysis. To compare the components of functional capacity between the groups was used analysis of variance for repeated measures two-way ANOVA and the level of significance was set at 5 %. RESULTS: The functional components remained favorable, highlighting Agility (pre = 21.03 ± 1.64 sec./ post = 18.63 ± 2.26 sec.) And aerobic endurance (pre = 495.94 ± 46.48 sec. / post = 448.01 ± 12.27 sec.). In the comparison between positive and negative functional levels and mood states showed no relationship between these variables, dealing with different aspects and has influence one another. The state post-dancing sessions mood in GT were more positive even for elderly patients with depressive symptoms even unproven statistically, depressive symptoms were maintained or reduced mostly. CONCLUSION: The dance practice maintains the functionality of components; modifies mood states to positive levels and reduces or prevents the onset of depressive symptoms and complications in elderly

As relações interpessoais e a ludicidade no contexto do 1º ano do ensino fundamental

The aim of this study is to investigate the importance of playfulness and interpersonal relationships at school. The methodology of the study was divided into three phases: the first phase was a survey and analysis of studies in the field of childhood playfulness and interpersonal relationships, from a reference from a multidisciplinary reference, supported in the areas of Educational Psychology and history and sociology of childhood and the second was the realization of an empirical study in a classroom of 1st year of elementary school, in which we use as instruments the use of participant observation, semistructured interviews with six selected students and collected school records and the third phase focused on analysis of data from a qualitative perspective with dialogues between literature in the area and data analysis. Among the main directions of study have the following problematizations: school world not adapted in order to enroll in elementary school, lack of playfulness, interpersonal relations in this context. By analyzing this information and the main results we have the advancement of education in the new environment where playfulness, as the jokes were not taken during the year by the teacher, but remained present in the actions of children, highlighting also the symbolism and sets of rules. Interpersonal relationships were present at all times, between being a friend, share and discuss, through the interactions. Therefore, we consider that there are still challenges to deal with this new child who enters school as it relates to your mood, the play, study or friendship

Orações subjetivas: variância e invariância de padrões na fala e na escrita

This work investigates the variance and invariance of subject clauses patterns in spoken and written contemporary Brazilian Portuguese. I analyze four parameters (category and semantic class of matrix predicate, form of embedded clause and mood-tense correlation between matrix and embedded clauses) and show that there is less variance in speech patterns.

Ginástica laboral, música e estados de ânimo

Pós-graduação em Ciências da Motricidade - IBRC

Moda e literatura: a poética do vestuário em Macedo e Alencar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeito de métodos de desgaste com pontas diamantadas e da ressinterização sobre o limite de fadiga flexural de uma zircônia parcialmente estabilizada por ítria

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A produção e a compreensão do humor por uma criança bilíngue: um estudo de caso

Pós-graduação em Linguística e Língua Portuguesa - FCLAR

Effect of lithium on behavioral disinhibition induced by electrolytic lesion of the median raphe nucleus

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Métodos de avaliação da eficácia dos tratamentos para a dor

Pain is a subjective condition and, thus, difficult to measure. The best tools to assess pain are the pain evaluation questionnaires, which provide either diagnostic, pain evolution or pain intensity information. To provide information which could help differentiate between nociceptive pain and neuropathic pain is one of the most important functions of these questionnaires. The questionnaires can measure pain intensity, quality of life, or sleep quality. Quality of life and sleep are two really important characteristics to assess the pain impact on patients' life. Pain intensity assessing questionnaires combine physical evaluations with questions, providing information either from the patient sensations or clinical assessment of pain manifestations as well as the underlying biological mechanisms (such as hyperalgesia or allodynia). For example, the Pain Detect questionnaire has two parts: the patient form (intuitive, with pictures and easy understandable) and the physician form. Thus, in this questionnaire, subjective information is provided by the patient and the objective one is provided by the physician. Other pain intensity questionnaires are NPSI, DN4, LANSS or StEP. Quality of life questionnaires are versatile (can be used in different pathologies). These questionnaires include functional self-evaluation questions, and other ones associated to physical and mental health. Two of such quality of life questionnaires are SF-36 and NHP. Sleep evaluation questionnaires include quantitative features such as the number of sleep interruptions, sleep latency or sleep duration as well as qualitative characteristics such as rest sensation, mood and dreams. One of the most used sleep evaluation questionnaires is PSQI, which includes patient questions and bed-partner questions, providing information from two points of view.

Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats

Comorbidity between mood disorders and cardiovascular disease has been described extensively. However, available antidepressants can have cardiovascular side effects. Treatment with selective inhibitors of neuronal nitric oxide synthase (nNOS) induces antidepressant effects, but whether the antidepressant-like effects of these drugs are followed by cardiovascular changes has not been previously investigated. Here, we tested in male rats exposed to chronic variable stress (CVS) the hypothesis that nNOS blockers are advantageous compared with conventional antidepressants in terms of cardiovascular side effects. We compared the effects of chronic treatment with the preferential nNOS inhibitor 7-nitroindazole (7-NI) with those evoked by the conventional antidepressant fluoxetine on alterations that are considered as markers of depression (immobility in the forced swimming test, FST, decreased body weight gain and increased plasma corticosterone concentration) and cardiovascular changes caused by CVS. Rats were exposed to a 14-day CVS protocol, while being concurrently treated daily with either 7-NI (30 mg/kg) or fluoxetine (10 mg/kg). Fluoxetine and 7-NI prevented the increase in immobility in the FST induced by CVS and reduced plasma corticosterone concentration in stressed rats. Both these treatments also prevented the CVS-evoked reduction of the depressor response to vasodilator agents and baroreflex changes. Fluoxetine and 7-NI-induced cardiovascular changes independent of stress exposure, including cardiac autonomic imbalance, increased intrinsic heart rate and vascular sympathetic modulation, a reduction of the pressor response to vasoconstrictor agents, and impairment of baroreflex activity. Altogether, these findings provide evidence that fluoxetine and 7-NI have similar effects on the depression-like state induced by CVS and on cardiovascular function.