Avaliação microbiológica de carcaças congeladas de perus adquiridas no comércio varejista

Pós-graduação em Medicina Veterinária - FCAV

Tumor venéreo transmissível canino com enfoque nos diversos tratamentos

The canine Transmissible Venereal Tumor (TVT) is a neoplasm of round cells that primarily affects the external genitalia of both male and female dogs with high casuistry. Its transmission occurs by the tumor cells’ implementation in the mucous membranes during the coitus or in other body parts through licking, scratching or direct contact with the tumor. The clinical manifestations vary according to the location. Despite being a malignant neoplasm, TVT’s metastatic potential is low. The diagnosis is based on macroscopic characteristics, clinical signs, cytology and/or histopathology exam, among which cytology is considered the best method. There are several treatment protocols for the TVT, among which, surgical excision, radiotherapy, immunotherapy and chemotherapy. Chemotherapy with vincristine sulfate is the elected treatment. However, more and more new alternatives have been developed, as the usage of natural products, homeopathy and ivermectina. They can be used as a unique treatment to neoplasm or combined to the chemotherapy in order to decrease the dose and the application number of the chemotherapic and its side effects

Expressão dos genes MDR-1, TP53, BCL-2 e BAX em tumor venéreo transmissível canino e sua relação com a agressividade e resposta à terapia

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

E.F. Perus Pirapora: personagens, posicionamentos e conflitos no processo de tombamento estadual (São Paulo/SP)

The process of recognition by the State of E. F. Perus Pirapora records the progress along many different interests and opinions, differences and conflicts unresolved even after the definition of recognition. Different opinions identified and their possible relationships with the subsequent abandonment of the property justify research efforts. Result of discussions over the development of a scientific research about industrial heritage, this article identifies people interested in this subject and conflicts presented in recognition 21.273/80. We understand this identification as possible subsidy for reflections about values, uses and management of the property recognized. Among the methods highlight the documentary research and interviews with the people involved in the recognition of the property. The process 21.273/80 was the focus of our investigation and it has been taken as official record of interests and positions of the people involved. The research concludes that conflicts between requestor and owner limited the effectiveness of the tool of recognition, resulting in abandonment and degradation of the heritage recognized. We also identify the positive presence of the government in this case represented by the Department of Culture of the State of São Paulo and CONDEPHAAT, on the management of the conflicts and the actions to safeguard the E.F. Perus Pirapora.

Toxicidade do cloridrato de doxorrubicina na dose de 120mg/m², em cadelas com tumor venéreo transmissível

Pós-graduação em Cirurgia Veterinária - FCAV

Perfil tóxico-farmacológico da administração da doxorrubicina em cães com tumor venéreo transmissível

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Uso da radioterapia no tumor venéreo transmissível em cães

Since the discovery of x rays, the use of radiation in oncology has advanced remarkably. In Brazil, radiation therapy in animals is limited to some isolated studies in public universities and the procedures performed is still precarious because radiation equipments are expensive and there is still a lack of skilled professionals. The transmissible venereal tumor (TVT) is a contagious neoplasm of spontaneous occurrence, commonly treated with vincristine. This paper describes the positive experience of radiotherapy as an isolated option or as an combined treatment with vincristine in three cases of TVT. It was observed that radiotherapy may be used in routine clinical chemotherapy alone or combined with chemotherapy since suitable sources of radiation are provided.

Perfil fenotípico de potenciais células iniciadoras tumorais no tumor venéreo transmissível canino ex vivo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Tumor venéreo transmissível canino - I. Expressão gênica e proteica e caracterização genotípica de DLADQA-1 (MHC-II); II. Estudo imuno-histoquímico da resposta imune local

Pós-graduação em Medicina Veterinária - FCAV

Tumor venéreo transmissível canino: expressão dos genes MDR-1, TP53 e da família Bcl-2 e suas implicações no comportamento biológico e terapêutico

Transmissible venereal tumor (TVT) is a neoplasm of round cells with plasmocytoid or lymphocytoid appearance. The tumor presents several particularities, which have been the subject of numerous studies; however there still have investigations that need to be done. For example, a progressive increase of highly aggressive tumors with varying response to chemotherapy -including resistance- has been evidenced in recent years. There is scientific interest to understand these differences, allowing predicting possible clinical outcomes in affected dogs and increasingly searching adequate and individualized therapy. This review focuses on presenting possible implications of the expression of MDR-1 (P-glycoprotein), TP53, BCL-2, and BAX genes, regarding resistance to chemotherapy and/or the biologic behavior of TVT

Densidade mineral óssea de perus de corte vacinados e não vacinados contra coccidiose

It was evaluated bone mineral density of turkeys submitted the vaccination against coccidiosis. Used 420 turkeys of one day, divided in 4 treatments with 5 repetitions: T1 – control diet; T2 - diet and anti coccidiosis drugs; T3 - diet and commercial vaccine; T4 - diet and recombinant vaccine. To the 28 days the birds had been submitted to the challenge of coccidiosis, carried through inoculation of oocisty talked back directly in the esophagus of the birds. The bone quality was evaluated to the 21, 35, 49 and 72 days of age. For this, 8 birds for treatment had been collected, in each age of collection that had been sacrificed by cervical displacement. The tibiae and femura had been radiographed and tomographed for evaluation of the bone density, had been later evaluated texts of dry substance, bone ashes, calcium and of phosphorus. It had differences only between the ages, being that the treatments had not caused alterations of the bone characteristics. To the 56 days the birds had presented bone quality worse. The treatments had not influenced the studied parameters. What it allows to conclude that the vaccination against coccidiosis promotes good mineralization of the bones.