Paesaggi di archeologia. Una proposta per Suasa Senonum

Il progetto di musealizzazione dell’area archeologica di Suasa pone le basi sullo studio dei legami storici, culturali e paesaggistici che si sono instaurati sin dall’epoca romana e permangono tutt’oggi. Il primo passo parte dallo studio della Salaria Gallica: nasce così la volontà di mantenere la Salaria usufruibile da tutti, richiamando quindi l’interesse di un pubblico di vario target intorno l’area di progetto . Da questa principio si rende quindi necessaria una prima divisione dell’aria in una parte pubblica ed una privata, la prima interessata dalla costruzione di un nuovo spazio polifunzionale, la seconda destinata al mantenimento delle tracce (archeologiche e paesaggistiche). Si rende fondamentale nello spazio pubblico la costruzione di un nuovo edificio che vada ad ospitare funzioni utili alle due aree, una costruzione che è figlia di principi che caratterizzano l’area sin dall’epoca romana: la viabilità antica e le maglie generatrici. Lo spazio privato, reso tale attraverso la costruzione di un limite fisico è a sua volta diviso in due parchi: il parco archeologico e il parco agricolo. Il parco archeologico è interessato dalla costruzione di una copertura atta alla salvaguardia delle tracce di una delle istanze archeologiche di maggior valore : la Domus dei Coiedii. I principi che contraddistinguono il progetto sono quelli di riproporre, a scopo educativo, la volumetria antica della domus, mantenendo però una pianta libera che sottolinei la maestosità che fu. Si ha così una triade di parchi, legati fra loro da elementi ordinatori che nascono da una rilettura di sistemi romani ed una riproposizione di tali. Si tratta degli elementi d’ombra, che riprenderanno le strutture a sacco tipiche romane, e dei percorsi studiati per sottolineare la gerarchia delle tracce.

Sviluppo di una applicazione di test per un sistema di localizzazione

La tesi consiste nella descrizione di una applicazione in Java atta a eseguire test e simulazioni di un sistema di localizzazione in radiofrequenza. Viene descritta l'interfaccia e le funzionalità.

Analysis of ⁸⁵Kr: a comparison at the 10-14 level using micro-liter samples

The isotopic abundance of 85Kr in the atmosphere, currently at the level of 10−11, has increased by orders of magnitude since the dawn of nuclear age. With a half-life of 10.76 years, 85Kr is of great interest as tracers for environmental samples such as air, groundwater and ice. Atom Trap Trace Analysis (ATTA) is an emerging method for the analysis of rare krypton isotopes at isotopic abundance levels as low as 10−14 using krypton gas samples of a few micro-liters. Both the reliability and reproducibility of the method are examined in the present study by an inter-comparison among different instruments. The 85Kr/Kr ratios of 12 samples, in the range of 10−13 to 10−10, are measured independently in three laboratories: a low-level counting laboratory in Bern, Switzerland, and two ATTA laboratories, one in Hefei, China, and another in Argonne, USA. The results are in agreement at the precision level of 5%.

Tracer applications of noble gas radionuclides in the geosciences

Noble gas radionuclides, including 81Kr (t1/2 = 229,000 years), 85Kr (t1/2 = 10.8 years), and 39Ar (t1/2 = 269 years), possess nearly ideal chemical and physical properties for studies of earth and environmental processes. Recent advances in Atom Trap Trace Analysis (ATTA), a laser-based atom counting method, have enabled routine measurements of the radiokrypton isotopes, as well as the demonstration of the ability to measure 39Ar in environmental samples. Here we provide an overview of the ATTA technique, and a survey of recent progress made in several laboratories worldwide.We review the application of noble gas radionuclides in the geosciences and discuss how ATTA can help advance these fields, specifically: determination of groundwater residence times using 81Kr, 85Kr, and 39Ar; dating old glacial ice using 81Kr; and an 39Ar survey of the main water masses of the oceans, to study circulation pathways and estimate mean residence times. Other scientific questions involving a deeper circulation of fluids in the Earth's crust and mantle are also within the scope of future applications. We conclude that the geoscience community would greatly benefit from an ATTA facility dedicated to this field, with instrumentation for routine measurements, as well as for research on further development of ATTA methods.

Radiometric 81Kr dating identifies 120,000-year-old ice at Taylor Glacier, Antarctica

We present successful 81 Kr-Kr radiometric dating of ancient polarice. Krypton was extracted from the air bubbles in four∼350-kg polar ice samples from Taylor Glacier in the McMurdo Dry Valleys, Antarctica, and dated using Atom Trap Trace Analysis (ATTA). The 81 Kr radiometric ages agree with independent age estimates obtained from stratigraphic dating techniques with a mean abso-lute age offset of 6±2.5 ka. Our experimental methods and sampling strategy are validated by (i) 85 Kr and 39 Ar analyses that show the samples to be free of modern air contamination and (ii)air content measurements that show the ice did not experience gas loss. We estimate the error in the 81 Kr ages due to past geomagnetic variability to be below 3 ka. We show that ice from the previous interglacial period (Marine Isotope Stage 5e, 130–115 ka before present) can be found in abundance near the surface of Taylor Glacier. Our study paves the way for reliable radiometric dating of ancient ice in blue ice areas and margin sites where large samples are available, greatly enhancing their scientific value as archives of old ice and meteorites. At present, ATTA 81Kr analysis requires a 40–80-kg ice sample; as sample requirements continue to decrease, 81 Kr dating of ice cores is a future possibility.

Factors associated with diabetes in tuberculosis patients in Harris County, Texas 1995--2004

Objective. To determine the prevalence and factors associated with diabetes in tuberculosis patients in Harris County, Texas. ^ Background. Tuberculosis and diabetes mellitus are two diseases of immense public health significance. Various epidemiologic studies have established an association between the two conditions. While many studies have identified factors associated with the conditions individually, few have looked at factors associated with their co-occurrence particularly in the United States. Furthermore, most of those studies are hospital-based and may not be representative of the population. The aim of this study was to determine the prevalence and distribution of diabetes among tuberculosis patients in Harris County, Texas and to identify the factors associated with diabetes in tuberculosis. ^ Methods. A population-based case control study was performed using secondary data from the Houston Tuberculosis Initiative (HTI) collected from October 1995 to September 2004. Socio-demographic characteristics and clinical variables were compared between tuberculosis patients with diabetes and non-diabetic tuberculosis patients. Logistic regression analysis was performed to identify associations. Survival at 180 days post tuberculosis diagnosis was assessed by Cox regression. ^ Results. The prevalence of diabetes among the tuberculosis (TB) population was 14.4%. The diabetics (cases) with a mean age 53 ± 13.3 years were older than the non-diabetics (controls) with a mean age of 39 ± 18.5 years (p<0.001). Socio-demographic variables that were independently associated with the risk of diabetes were age (OR 1.04, p<0.001) and Hispanic ethnicity (OR 2.04, p<0.001). Diabetes was associated with an increased risk of pulmonary tuberculosis disease (OR 1.33, p<0.028). Among individuals with pulmonary TB, diabetes was associated with positive sputum acid-fast bacilli (AFB) smear (OR 1.47, p<0.005) and culture (OR 1.83, p<0.018). Diabetics were more likely to have cavitary lung disease than non-diabetics (OR 1.50, p<0.002). After adjustment for age and HIV status, the risk of dying within 180 days of TB diagnosis was significantly increased in the diabetics (HR 1.51, p<0.002). ^ Conclusion. Diabetes mellitus was more prevalent in our tuberculosis patients than in the general population. The tuberculous diabetic may be more infectious and has a higher risk of death. It is therefore imperative to screen diabetics for TB and TB patients for diabetes. ^

A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins

The cell adhesion molecule L1 regulates axonal guidance and fasciculation during development. We previously identified the regulatory region of the L1 gene and showed that it was sufficient for establishing the neural pattern of L1 expression in transgenic mice. In the present study, we characterize a DNA element within this region called the HPD that contains binding motifs for both homeodomain and Pax proteins and responds to signals from bone morphogenetic proteins (BMPs). An ATTA sequence within the core of the HPD was required for binding to the homeodomain protein Barx2 while a separate paired domain recognition motif was necessary for binding to Pax-6. In cellular transfection experiments, L1-luciferase reporter constructs containing the HPD were activated an average of 4-fold by Pax-6 in N2A cells and 5-fold by BMP-2 and BMP-4 in Ng108 cells. Both of these responses were eliminated on deletion of the HPD from L1 constructs. In transgenic mice, deletion of the HPD from an L1-lacZ reporter resulted in a loss of β-galactosidase expression in the telencephalon and mesencephalon. Collectively, our experiments indicate that the HPD regulates L1 expression in neural tissues via homeodomain and Pax proteins and is likely to be a target of BMP signaling during development.

Rilievi cinematici continui condotti con sensori a basso costo

Nel qui presente elaborato vengono descritte le principali caratteristiche del sistema di posizionamento GPS e le tecniche di rilievo. Particolare attenzione viene posta al rilievo cinematico continuo con sensori a basso costo (Ublox EVK 7P). Inotre verra descritta nel dettaglio la strumentazione atta ad acquisire il segnale, e la relativa preparazione. In particolare i dati acquisiti dalla strumentazione verranno elaborati con appositi software, dai quali si otterranno diverse soluzioni. Di seguito sara presente anche la procedura di elaborazione dei dati registrati. In fine le soluzioni ottenute saranno oggetto di confronto.

Heinrich Heine's sämmtliche werke.

12. Bd. Vermischte schriften: Einleitung zu "Kahldorf über den adel." Vorrede zum ersten bande des "Salon." Ueber den denuncianten. Der Schwabenspiegel. Einleitung zur prachtausgabe des "Don Quixote." Vorwort zu A. Weill's "Sittengemälden aus dem elsässichen volksleben." Thomas Reynolds. Ludwig Marcus. Loeve-Veimars. Autobiographische skizze. Albert Methfessel. Die romantik. Vershiedenartige geschichtsauffassung. Eingangswort zur uebersetzung eines lappländischen gedichts. Recensionen. Nachträge. Gedanken und einfälle.

Sämmtliche Gedichte.

Bd. 1. Buch der Lieder. Tragödien und neue Gedichte.--Bd. 2. Atta Troll, ein Sommernachtstraum; Deutschland, ein Wintermärchen; Zeitgedichte; Romancero; Letzte Gedichte. Nebst Letzte Gedichte und Gedanken. (Aus dem Nachlasse des Dichters.)

Heinrich Heine's sämmtliche Werke.

Vol. 7 published by J. Weik.

Heinrich Heine's sämmtliche werke.

1. bd. Biographie, von dr. G. Karpeles. Buch der lieder.--2. bd. Neue gedichte. Zeitgedichte. Atta Troll. Deutschland, ein wintermärchen.--3. bd. Romancero. Letze gedichte.--4 bd. Tragödien. Shakspeare's mädchen und frauen.--5. bd. Reisebilder I. Memoiren.--6. bd. Resisebilder II. Englische fragmente.--7. bd. Deutschland I.: Zur geschichte der religion und philosophie in Deutschland. Die romantische schule.-- 8. bd. Deutschland II.: Geständnisse. Elementargeister. Der doktor Faust. Die götter im exil. Die göttin Diana.--9. bd. Französische zustände. I.: Das bürgerkönigthum im jahre 1832. Lutetia.--10. bd. Französische zustände. II. Lutetia (fortsetzung) Kunstberichte aus Paris: Französische maler. Über die französische bühne. Musikalische berichte aus Paris.--11. bd. Novellistische fragmente: Der rabbi von Bacharach. Memoiren des herrn von Schnabelewopski. Florentinische nächte. Ludwig Börne.--12. bd. Vermischte schriften: Einleitung zu "Kahldorf über den adel." Vorrede zum ersten bande des "Salon." Ueber den denuncianten. Der Schwabenspiegel. Einleitung zur prachtausgabe des "Don Quixote." Vorwort zu A. Weill's "Sittengemälden aus dem elsässischen volksleben." Thomas Reynolds. Ludwig Marcus. Loeve-Veimars. Autobiographische skizze. Albert Methfessel. Die romantik. Verschiedenartige geschichtsauffassung. Eingangsworte zur eubersetzung eines lappländischen gedichts. Recensionen. Nachträge. Gedanken und einfälle.

Heinrich Heine's sämmtliche werke.

Edition varies.

Heinrich Heine's Sämmtliche Werke.

Edited by Becker.

Agonists and antagonists of protease activated receptors (PARs)

Protease activated receptors (PARs) are a category of G-protein coupled receptors (GPCRs) implicated in the progression of a wide range of diseases, including thrombosis, inflammatory disorders, and proliferative diseases. Signal transduction via PARs proceeds via an unusual activation mechanism. Instead of being activated through direct interaction with an extracellular signal like most GPCRs. they are self-activated following cleavage of their extracellular N-terminus by serine proteases to generate a new receptor N-terminus that acts as an intramolecular ligand by folding back onto itself and triggering receptor activation. Short synthetic peptides corresponding to this newly exposed N-terminal tethered ligand can activate three of the four known PARs in the absence of proteases. and such PAR activating peptides (PAR-APs) have served as templates for agonist/antagonist development. In fact much of the evidence for involvement of PARs in diseases has relied upon use of PAR-APs. often of low potency and uncertain selectivity. This review summarizes current structures of PAR agonists and antagonists, the need for more selective and more potent PAR ligands that activate or antagonize this intriguing class of receptors, and outlines the background relevant to PAR activation, assay methods, and physiological properties anticipated for PAR ligands.