5 resultados para GLOMERULONEFRITIS

em Bioline International


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The glomerulonephritis is defined here as a disease characterized by intraglomerular inflammation and cellular proliferation asociatted with hematuria. Both humoral and cell-mediaded immune mechanisms play a part in the pathogenesis of glomerular inflammation. The complement system has long been recognized as having a role in immune glomerular disease. Evidence of complement activation in glomerulonephritis come from characteristic patterns of decrease in the serum concentrations of specific componenets, some of wich are virtually diagnostic of certain nephritides. Specific glomerular diseases tend to produce particular syndromes of renal dysfunction, althought multiple glomerular diseases can produce the same syndrome. We will review the pathophysiology, natural history and treatment of the asymptomatic hematuria, acute glomerulonephritis, rapidly progressive glomerulonephritis and nephrotic syndrome

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Acute glomerulonephritis (GNA) is a wide group of diseases with the common characteristics of abrupt onset and proliferation of endocapillary glomerular cells. Clinically, they usually manifest as acute nephritic syndrome: hematuria, acute renal failure, hypertension and mild proteinuria, although they can appear as recurrent hematuria. GNA can be present in association with a variety of bacterial and viral infections, but in most cases the initial antigenic initiating stimulus is unknown. Patients with rapidly progressive glomerulonephritis often present acute onset of manifestations of nephritis, such as azotemia, oliguria, edema, hypertension, proteinuria, and hematuria with «active» urine sediment that often contains red blood cell casts, pigmented casts, and cellular debris. This article, aimed at all primary care staff and seeking to increase their awareness of this disease, discusses in more detail the clinical, pathogenesis, pathology, and treatments available from one of the glomerulonephritis with greater impact on survival patient.

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Objetivo: Descrever o perfil epidemiológico de pacientes submetidos ao tratamento de terapia renal substitutiva na modalidade hemodiálise, além de verificar as dificuldades na sua realização. Métodos: Trata-se de um estudo transversal, realizado em Itapipoca-CE, com 35 pacientes portadores de insuficiência renal crônica (IRC). Os dados gerais foram analisados de forma descritiva usando as frequências absolutas e percentuais. Resultados: O perfil epidemiológico aponta uma maior frequência de pacientes: do sexo masculino (19 - 54,3%), com idade entre 31 e 60 anos (24 - 68,6%), baixa escolaridade (29 - 82,8%), renda familiar de 1 a 2 salários mínimos (25 - 71,4%), morando em casa de alvenaria (30 - 85,7%) e dispondo de água tratada em seus domicílios (17 - 48,6%). Os principais sinais e sintomas que levaram à busca da consulta médica foram: fraqueza geral (21 - 60%), náuseas (19 - 54,3%), edema (18 - 51,4%) e falta de apetite (14 - 40%). Os fatores mais frequentemente apontados pelos pacientes como prováveis causas da IRC englobavam: associação de hipertensão arterial (HAS) com diabetes mellitus (11 - 31,4%); HAS (9 - 25,7%); e glomerulonefrites (5 - 14,3%). A maioria dos pacientes relatou dificuldade para obter consulta médica (25 - 71,4%) e marcar/receber exames (20 - 57,1%). Conclusão: O perfil epidemiológico dos pacientes estudados é marcado por um baixo nível socioeconômico. Como agravante dessa situação, verificou-se a dificuldade de obterem consultas médicas, marcarem e realizarem exames diagnósticos, criando prejuízos para a realização do tratamento.

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Objective: To describe the epidemiological profile of patients undergoing treatment for renal replacement therapy in dialysis modality, and to identify the difficulties in its realization. Methods: This is a cross-sectional study conducted in Itapipoca-CE, comprising 35 patients with chronic renal failure (CRF). The general data was analyzed descriptively using absolute and percentage frequencies. Results: The epidemiological profile of patients shows a higher frequency of: males (19 - 54.3%) aged between 31 and 60 (24 - 68.6%), low education (29 - 82.8%), family incomes of 1 to 2 minimum wages (25 - 71.4%), living in houses of masonry (30 - 85.7%) with treated water provided in their homes (17 - 48.6%). The main signs and symptoms that led to seeking medical consultation were: general weakness (21 - 60.0%), nausea (19 - 54.3%), edema (18 - 51.4%) and lack of appetite (14 - 40.0%). The features most frequently mentioned by the patients as probable causes to CRF were: association of hypertension with diabetes mellitus (11 - 31.4%), hypertension (9 - 25.7%) and glomerulonephritis (5 - 14.3%). Most patients reported difficulty in obtaining medical appointment (25 - 71.4%) and scheduling/receiving exams (20 - 57.1%). Conclusion: The epidemiological profile of patients studied is marked by a low socioeconomic status. As aggravating factors to this situation, there was the difficulty in getting appointments, scheduling and performing diagnostic tests, which undermines the treatment.

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Introduction: Glomerulonephritis is the most common cause of acute and chronic renal disease. The prototype of acute glomerulonephritis is acute post-infectious glomerulonephritis. Recently, increased cases of glomerulopathy have been associated with bacterial, viral, and other infections. Acute nephritic syndrome is part of glomerulonephritis with an acute beginning, characterized by hematuria, hypertension, edema, and oliguria due to the reduction of glomerular filtration reflected in an increase of nitrogen compounds. Development: This paper shows a male infant at 2 years and 7 months of age with nephritic syndrome associated to a skin infection, pneumonia, and hepatitis A virus infection. Conclusion: Acute glomerulonephritis may be associated to streptococcus or another coincidental infection. Children with skin infection, hepatitis A, or pneumonia who reveal abnormal urinalysis, hypertension, azotemia, or oliguria should be evaluated for concomitant glomerulonephritis.