1 resultado para identity by descent mapping
em University of Connecticut - USA
Filtro por publicador
- Aberystwyth University Repository - Reino Unido (7)
- Adam Mickiewicz University Repository (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (2)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (1)
- Aquatic Commons (18)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (3)
- Archive of European Integration (4)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (9)
- Aston University Research Archive (7)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (7)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (3)
- Biblioteca Digital de la Universidad Católica Argentina (2)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (13)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (33)
- Boston University Digital Common (10)
- Brock University, Canada (3)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- Bulgarian Digital Mathematics Library at IMI-BAS (2)
- CaltechTHESIS (5)
- Cambridge University Engineering Department Publications Database (16)
- CentAUR: Central Archive University of Reading - UK (11)
- Central European University - Research Support Scheme (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (60)
- Cochin University of Science & Technology (CUSAT), India (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (15)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (1)
- Dalarna University College Electronic Archive (2)
- Deakin Research Online - Australia (20)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (4)
- DigitalCommons@The Texas Medical Center (8)
- DRUM (Digital Repository at the University of Maryland) (5)
- Duke University (13)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (16)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (5)
- Helda - Digital Repository of University of Helsinki (31)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (3)
- Indian Institute of Science - Bangalore - Índia (61)
- Institutional Repository of Leibniz University Hannover (2)
- Instituto Gulbenkian de Ciência (1)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (1)
- Massachusetts Institute of Technology (1)
- Memoria Académica - FaHCE, UNLP - Argentina (7)
- National Center for Biotechnology Information - NCBI (26)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (5)
- Portal de Revistas Científicas Complutenses - Espanha (9)
- Publishing Network for Geoscientific & Environmental Data (3)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (100)
- Queensland University of Technology - ePrints Archive (271)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositorio Académico de la Universidad Nacional de Costa Rica (1)
- Repositório Científico da Escola Superior de Enfermagem de Coimbra (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (2)
- Repositório digital da Fundação Getúlio Vargas - FGV (2)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (40)
- Repositorio Institucional Universidad de Medellín (1)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Universidad del Rosario, Colombia (1)
- Universidad Politécnica de Madrid (10)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal de Uberlândia (1)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (3)
- Universidade Metodista de São Paulo (4)
- Université de Lausanne, Switzerland (3)
- Université de Montréal (2)
- Université de Montréal, Canada (15)
- University of Connecticut - USA (1)
- University of Michigan (9)
- University of Queensland eSpace - Australia (16)
- University of Washington (2)
- WestminsterResearch - UK (4)
Resumo:
Microvariant alleles, defined as alleles that contain an incomplete repeat unit, often complicate the process of DNA analysis. Understanding the molecular basis of microvariants would help to catalogue results and improve upon the analytical process involved in DNA testing. The first step is to determine the sequence/cause of a microvariant. This was done by sequencing samples that were determined to have a microvariant at the FGA or D21S11 loci. The results indicate that a .2 microvariant at the D21S11 locus is caused by a -TA- dinucleotide partial repeat before the last full TCTA repeat. The .2 microvariant at the FGA locus is caused by a -TT- dinucleotide partial repeat after the fifth full repeat and before the variable CTTT repeat motif. There are several possibilities for the reason the .2 microvariants are all the same at a locus, each of which carry implications on the forensic community. The first possibility is that the microvariants are identical by descent, which means that the microvariant is an old allele that has been passed down through the generations. The second possibility is that the microvariants are identical by state, which would mean that there is a mechanism selecting for these microvariants. Future research studying the flanking regions of these microvariants is proposed to determine which of these possibilities is the actual cause and to learn more about the molecular basis of microvariants.