151 resultados para HEPATITIS B VIRUS
Filtro por publicador
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (12)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (1)
- ARCA - Repositório Institucional da FIOCRUZ (2)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (14)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (5)
- Aston University Research Archive (14)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (4)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (47)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (8)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (5)
- Bioline International (9)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (151)
- Brock University, Canada (2)
- CaltechTHESIS (1)
- CentAUR: Central Archive University of Reading - UK (12)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (14)
- CORA - Cork Open Research Archive - University College Cork - Ireland (5)
- Deakin Research Online - Australia (36)
- Digital Repository at Iowa State University (1)
- DigitalCommons@The Texas Medical Center (33)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (11)
- Düsseldorfer Dokumenten- und Publikationsservice (2)
- FUNDAJ - Fundação Joaquim Nabuco (2)
- Glasgow Theses Service (2)
- Helda - Digital Repository of University of Helsinki (4)
- Indian Institute of Science - Bangalore - Índia (33)
- Instituto Nacional de Saúde de Portugal (2)
- Instituto Politécnico de Viseu (1)
- Instituto Politécnico do Porto, Portugal (1)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Iowa Publications Online (IPO) - State Library, State of Iowa (Iowa), United States (2)
- Ministerio de Cultura, Spain (1)
- National Center for Biotechnology Information - NCBI (70)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (29)
- Queensland University of Technology - ePrints Archive (21)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (2)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (2)
- Repositório Institucional da Universidade de Brasília (1)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal de Goiás - UFG (1)
- Repositório Institucional da Universidade Federal de São Paulo - UNIFESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (138)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (4)
- School of Medicine, Washington University, United States (1)
- Scielo España (3)
- Scientific Open-access Literature Archive and Repository (3)
- Universidad Autónoma de Nuevo León, Mexico (3)
- Universidad de Alicante (3)
- Universidad del Rosario, Colombia (10)
- Universidade Complutense de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Federal do Pará (30)
- Universidade Federal do Rio Grande do Norte (UFRN) (3)
- Universitat de Girona, Spain (1)
- Université de Lausanne, Switzerland (17)
- Université de Montréal (1)
- Université de Montréal, Canada (23)
- University of Canberra Research Repository - Australia (1)
- University of Michigan (9)
- University of Queensland eSpace - Australia (35)
- University of Washington (1)
- WestminsterResearch - UK (1)
Resumo:
Short synthetic peptides are important tools in biomedical research permitting to generate hapten specific polyclonal sera for analytical purposes or functional studies. In this paper we provide proof of principle that a peptide located in a highly conserved portion of the Gag protein of the caprine arthritis encephalitis virus and carrying an immunodominant T helper cell epitope functions as an efficient carrier peptide, mediating a strong antibody response to a peptidic hapten encompassing a well-characterized B cell epitope of Env. The carrier and hapten peptides were collinearly synthesized permutating their molecular arrangement. While the antibody response to the hapten was similar for both constructs, the antibody response to a B cell epitope overlapping the T helper cell epitope of the Gag carrier peptide was considerably different. This permits a modular use of the carrier peptide to generate antibody directed exclusively to the hapten peptide or a strong humoral response to both carrier- and hapten-peptide. Finally, we have mapped the epitopes involved in this polarized antibody response and discussed the potential immunological implications.