Biomassa da bactéria Rubrivivax gelatinosus proveniente do tratamento de efluente de piscicultura melhora a saúde dos peixes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Diagnóstico de situação das práticas de manejo sanitário em sistemas de produção de bovinos de corte

We interviewed 21 farmers in order to access which sanitary practices adopted in the production systems of beef cattle on farms located in São Paulo, Mato Grosso, Mato Grosso do Sul and Rondonia. The survey was conducted through a qualitative approach to the collection of data obtained through questionnaire and personal interview with the landowners. We questioned the attitudes and sanitation procedures in these current production systems such as veterinary assistance, preventive health practices and disease surveillance, knowledge of health hazards for the safe production of food, animal feed, vaccine and immunizations, registration system, measures with newborns, products used in the environment and animals, grace period, employee training, destination of the dead animals, among others. Along with the data found that only 30% of properties had veterinary care, 67% said they meet the expiration dates of the products, although it was not mentioned on the products if there were any. In only 48% of properties were veterinarians who prescribed drugs to animals. Only two of the owners confirmed buying and using expired products in animals and only 48% have received some training on the property. In this setting, it is evident that farmers should be better prepared for insertion of its products in a highly demanding and competitive market. In this context, add value to the product depends mainly on the condition of sanitation of the herds.

Vacina de DNA: uma alternativa para o tratamento do melanoma canino: revisão de literatura

O melanoma é considerado um dos tumores cutâneos de maior importância em cães devido ao seu caráter agressivo, à capacidade de produzir metástases em estágios precoces e à baixa resposta aos tratamentos não cirúrgicos. Recentemente, as vacinas de DNA apresentam-se promissoras na terapêutica do melanoma canino. O objetivo deste trabalho é apresentar uma revisão bibliográfica sobre o assunto. As vacinas de DNA são baseadas em plasmídeos que contêm o gene codificante para o antígeno alvo, expressando-o na célula do hospedeiro e apresentando, assim, vantagens em relação às vacinas tradicionais, como: facilidade de produção, estabilidade térmica, baixo custo e estimulação da resposta imune celular (linfócitos T CD8+). Devido ao sucesso limitado das terapias padrões, o estabelecimento de uma vacina de DNA efetiva aumenta a possibilidade de uma terapia promissora para o melanoma canino, podendo trazer novas expectativas aos animais portadores dessa neoplasia.

Avaliação dos conceitos sobre posse responsável exercida pela terceira idade em instituições não governamentais de Araçatuba-SP

Pets bring expressive benefits into the life of the elderly, so it becomes necessary to emphasize some of the concepts regarding responsible ownership consisting of a set of important attitudes that accounts for the well-being of all. In this context, non-governmental institutions represent an excellent mean of communication and information. Besides, the increase of the third aged people population indicates that a survey of parameters to this respect is necessary. Being thus, the objective of this work was to analyze the aged ones´ level of knowledge regarding their responsibility for their pet. A questionnaire was applied to 134 aged people, members of non-governmental organizations in the city of Araçatuba, SP, in order to find out how they took care of their pet animals. The pets aged from 2 to 336 months, being 43,3% mixed-breed animals. Out of that, 60,9% were male dogs and among cats, 65.2% were female cats. There was a 69.4% preference for dogs and a 17.9% preference for cats, only 10.5% of the elderly had preference for birds. From the descriptive statistics analysis it could be observed that 69.40% did not have any access to the street and that 50% did not have a veterinarian follow-up. Regarding vaccination it could be observed that 71.64% had received the rabies vaccine and 70.9% had received the combination vaccine. Also, 74.63% did not know the right moment to give medicines against animal worms. Another important fact was that 85.07% of the animals were not castrated and 84.91% were not under any preventive contraception method. In regard to food 50.75% of the animals were fed strictly with animal food, 12.69% with domestic food and 36.57% with both. Finally, 78.36% of the pets had never been ill. In this way, we can assure the importance of making responsible pet ownership measures well-known among third-aged people.

Leishmanioses: estado da arte

There is no vaccine available against leishmaniasis. Drug resistance, variable efficacy, toxicity, parenteral administration, and requirement for long courses of administration are the main drawbacks of current leishmanicidal drugs. Infections by protozoans of the genus Leishmania are the major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which exert renal and cardiac toxicity, thus, there is a strong need for safer and more effective treatments against leishmaniasis.

Imunohistoquímica em órgãos de tilápias-do-Nilo imunizadas com antígeno insolúvel de Streptococcus agalactiae

Pós-graduação em Medicina Veterinária - FCAV

Avaliação da participação e confiabilidade da população em relação à campanha de vacinação anual contra a raiva de cães e gatos no município de Botucatu, São Paulo, Brasil

The annual vaccination campaign against rabies is the most effective prevention procedure for this disease in dogs and cats and hence for human protection also. However, in 2010 and 2011, this activity was interrupted in Brazil due to the occurrence of adverse events associated with vaccination. Even though cases of canine rabies have been decreasing in the last two decades, vigilance must be strengthened in order to maintain pet owners trust in the vaccines provided in public services. This study aimed to determine pet owners participation in the annual vaccination campaign carried out in Botucatu. During March and April 2012, the period before the 42nd campaign, 312 pet owners, dogs and cats, were interviewed. The homes were randomly drawn in blocks from different sectors of the city; all houses on the same block over the 120 km² of urban area participated in the sampling process. Statistical analysis was performed descriptively. The results showed that the owners main motivation to vaccinate their pets during the campaigns is rabies prevention (36%), followed by the proximity of the vaccination station to the house (20.7%), zero cost (10.9%), and the combination of all three factors (16.1%). When asked if they would take their animals back to be vaccinated in another campaign, 60.1% answered yes, 13.5% would go to a private clinic, 2.2% would not take because they do not trust the vaccine and 1.6% had not decided yet. We conclude that the respondents have realized how dangerous Rabies is, because even after the break period, they still utilized the vaccination campaign demonstrating confidence in its effectiveness, while knowing the campaign goals facilitates understanding and participation.

Avaliação do conhecimento dos enfermeiros da rede de atenção à saúde do município de Botucatu sobre DPOC

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conhecimento sobre HPV (Papilomavírus Humano) e a percepção das adolescentes sobre sua imunização

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Avaliação da atividade antitumoral de uma clinoptilolita de origem natural e outra sintética em modelo experimental de EHRLICH

O câncer destaca-se pela alta incidência e mortalidade. Os tratamentos atualmente usados são agressivos e não específicos, com isso cresce a busca por novas drogas. Uma substância que vem despertando muito interesse são as zeólitas, minerais com característica porosa e estrutura conhecida. Estas possuem ações como adjuvante de vacinas, imunomoduladores e imunoestimuladores, o que desperta o interesse em estuda-las no modelo antitumoral. O presente estudo avaliou o efeito antitumoral e imunomodulador da zeólita natural clinoptilolita e da zeólita comercial, utilizando um modelo de câncer mamário (Tumor de Ehrlich). Para tanto a zeólita natural foi caracterizada (Microscopia Eletrônica de Varredura e Difração de raio X), realizada avaliação da viabilidade celular (ensaio de MTT), determinada a produção de óxido nítrico por macrófagos peritoneais, quantificação de citocinas (ELISA) e avaliação do crescimento tumoral. As zeólitas natural e comercial apresentaram elevada ativação de macrófagos, e não produziram quantidades significativas de NO. A zeólita natural apresentou citotoxicidade frente ao Tumor de Ehrlich em duas concentrações testadas (5 e 25 mg/ml). Não houve liberação significativa da citocina IL-10, no entanto os grupos que foram reestimulados com zeólita natural apresentaram maior liberação de IL-1β e TNF-α. Nos testes in vivo, a zeólita comercial foi a única que apresentou inibição tumoral frente ao Tumor de Ehrlich, sendo necessários estudos mais aprofundados para definir a sua atividade antitumoral nesse tipo celular.