Papel da proteína Mx1 na resposta a interferons e no processo neoplásico

The Mx1 protein is encoded by an interferon- induced gene and shares domain organization, homooligomerization capacity and membrane association with the large dynamin-like GTPases. The Mx1 protein is involved in the response to a large number of RNA viruses, such as the bunyavirus family and the influenza virus. Interestingly, it has also been found as a methylation-silenced gene in several types of neoplasm, including head and neck squamous cell carcinoma. In this scenario, MX1 gene silencing is associated with immortalization in several neoplastic cell lines. Thus, Mx1 stands out as one of the key proteins involved in interferon-induced immune response and also plays an important role in cell cycle control. Here we discuss some of the functions of the Mx1 protein, including its antiviral activity, protein folding and involvement in neoplasia, as well as those revealed by investigating its cellular partners.

Resposta produtiva do feijoeiro comum a diferentes manejos de irrigação

The objective of this work was to analyze the most appropriate management to achieve higher productivity for carioca beans (phaseolus vulgaris) and pearll cultivar. The research was developed in the Demonstrative and Experimental Area of Irrigation (ADEI) of FCAV/UNESP, Campus of Jaboticabal, SP. Four treatments were used: T1- irrigation with base in ETo estimated by the method of Class A pan; T2- irrigations based on the readings of tensiometers installed at 0,20 m and 0,40 m of depth; T3- irrigations carried out with base in ETo estimated by the method of Penman-Monteith and T4- witness. The results were submitted to analysis of variance. To compare the averages the test Turkey was used at 5% of probability. The treatment T3 had smaller applied water depth than the treatments T1 and T2, and also smaller productivity. The conclusion is that the treatments irrigated with larger frequency showed higher production of grains.

Resposta de cultivares de trigo ao nitrogênio com e sem tratamento fúngico

The fungicide can enhance response of nitrogen fertilization on wheat crop, since the application of higher N rates can provide better conditions for the development of some diseases. The present study investigated the effects of different nitrogen doses and fungicide application in preventive character on the yield of two cultivars of wheat irrigated, in Savannah conditions. The experiment was conducted in Selvíria - MS, in a Distrophic Red Latosol (Typic Haplustox). Treatments were arranged in a randomized block design, in a 4x2x2 factorial scheme: four N rates (0, 60, 120 and 180 kg ha-1), topdressing at the early boot stage as urea, two wheat cultivars (IAC 24 and IAC 370), and with and without fungicide application (Tebuconazole and Triciclazol), with four replications. The cultivars IAC 24 and IAC 370 present similar grain yield. The increase of N doses influences the mass hectoliter negatively and the leaf N content and number of ears per m2 positively. The increment of N doses increase the grain yield up to dose of 116 kg ha -1 of N, regardless of cultivar and of the fungicide application in preventive character, due to non occurrence of diseases in the experiment.

Brucella ovis: InvasãO, tráfego, fatores de virulência e resposta imune

Brucellosis remains an economic problem in animals and public health. Worldwide ovine brucellosis caused by Brucella ovis is considered a major cause of infertility in sheep. The factors responsible for persistence of the agent are not known, as well as the mechanisms involved in immune defense and possibly the persistence of the agent. Brucella spp. induces moderate inflammatory response. The nature of the intracellular agent stimulates immune response of the type 1 helper T lymphocytes. Studies of the pathogenesis of ovine brucellosis are scarce. Recent developments have shown that the inflammatory response induced by moderate brucelas represent probably the result of an attempt to escape the immune response and suppression of host immune response. Were reviewed by the mechanisms described by brucelas and Brucella ovis for penetration into the host, escape of the immune response and the immune response generated by the infection.

Resposta da alface à aplicação de biofertilizante sob dois níveis de irrigação

The use of biofertilizers is interesting for agriculture as being an economical alternative as well as it is environmentally friendly by using organic waste and reducing the application of mineral fertilizers. The aim of this study was to evaluate the effect of biofertilizer doses of bovine origin (biodigester effluent) applied on the ground and two levels of irrigation on lettuce. The experiment was conducted under protection of a greenhouse in pots, applying to the soil different doses of biofertilizer of bovine origin obtained from anaerobic reactor (10, 20, 40 and 60 m3 ha-1) and mineral fertilizer as a witness in two irrigation levels calculated at 50 and 100% of reference evapotranspiration. The lettuce plants were analyzed in their: Height, leaves number, crown diameter, fresh weight and dry weight of shoots. The biofertilizer treatments showed better results than the mineral fertilizer and has increased with increasing doses of biofertilizer, the highest dose (60 m3 ha-1) showed the best results in all variables. For dry, mineral fertilization showed higher values. The irrigation levels had no effect on plant growth.

O modelo 'hydrotime' pode descrever a resposta de sementes de feijão comum (phaseolus vulgaris l.) à temperatura e potenciais de água reduzidos

Germination parameters of the response to temperature and water potential from four common bean (Phaseolus vulgaris) lines based on thermal-time and hydrotime concepts were estimated to verify to what extent they can predict germination under different thermal and water conditions. The cultivars IPR Uirapuru and IAPAR 81 (drought-tolerant), and Grauna and Carioca (not tolerant) were used. The isothermal assays were performed in a temperature gradient block, and the assays with different osmotic potentials (PEG 6000) were performed in germination chambers. Seeds from drought-tolerant cultivars spent less time to germinate at supra-optimum temperatures than non-tolerant ones, and the cultivar Uirapuru (drought-tolerant) germinated faster in response to reduced Ψ and low temperatures. The parameter Ψb(50) did not discriminate between drought-tolerant and non-tolerant lines at the infraoptimum temperature range, but it can be used to identify drought-tolerant lines at high temperatures. In general, the hydrotime model reproduced the actual germination data relatively well, chiefly at higher temperatures. This study evidenced that the hydrotime model can be used to describe the germination of common bean seeds under reduced water potentials, and as a screening tool for drought-tolerant bean genotypes.

Atributos físicos de um Latossolo Vermelho distrófico degradado em resposta à aplicação de biossólidos

Sewage sludge, waste with high organic matter content and rapid decomposition, combined with sawdust, rich in carbon and slow decomposition, are suitable components for the study of degraded areas. In order to test the interactions of these residues in the recovery of a degraded soil in Selvíria - MS, four doses of sewage sludge (0, 8, 16 and 24 t ha -1, dry basis ) and four doses of sawdust particles (0, 8, 16 and 24 t ha-1, dry basis ) were tested in February 2009, in a completely randomized block design (4 × 4 + 1 factorial), with four replications. As indicators of the effects, the penetration resistance, gravimetric moisture and soil bulk density (0-0.10, 0.10-0.20; 0.20-0.40 m) were used. Significant effects were observed for the factors (sewage sludge and sawdust) and control treatment for penetration resistance in the soil depths studied, for gravimetric moisture in the intermediate layer and for the soil density in the surface and intermediate layers. Considering the type of soil and the short period of study (24 months), the use of organic wastes presented improvement in physical properties of soil in relation to control. However, it is necessary to study them for a longer period.

Resposta do milho à adição de níveis de fitomassa de Brachiaria decumbens Stapf e nitrogênio em latossolo vermelho

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Persistência de palhada de plantas de cobertura em função de doses de silício e resposta do feijoeiro em sucessão

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Comportamento de milho (Zea Mays L.) e propriedades físicas do solo, no sistema plantio direto, em resposta a aplicação de fertilizante organomineral

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Resposta de plantas de cobertura a doses de silício e estresse hídrico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Crescimento radicular e nutrição mineral de cultivares de feijão em resposta à calagem

Pós-graduação em Agronomia (Agricultura) - FCA

Resposta do feijoeiro (Phaseolus vulgaris L.) à adubação nitrogenada de cobertura em dois sistemas de manejo de solo

Pós-graduação em Agronomia (Agricultura) - FCA

Alterações dos atributos químicos do solo e resposta da soja à cobertura vegetal e à calagem superficial na implantação do sistema de semeadura direta

Pós-graduação em Agronomia (Agricultura) - FCA

Atividade mutagênica e ativadora da resposta imune celular induzidas por Byrsonima crassa Niedenzu e Byrsonima intermedia A.Juss. (Malpighiaceae)

Pós-graduação em Biociências e Biotecnologia Aplicadas à Farmácia - FCFAR