1 resultado para 3 ` non-coding region
em Digital Archives@Colby
Filtro por publicador
- Aberdeen University (1)
- Aberystwyth University Repository - Reino Unido (2)
- Academic Archive On-line (Jönköping University; Sweden) (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (19)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- Aquatic Commons (5)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (11)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (2)
- Aston University Research Archive (3)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (3)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (27)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (15)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (4)
- Bioline International (3)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (53)
- Boston University Digital Common (1)
- Brock University, Canada (10)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (4)
- Cambridge University Engineering Department Publications Database (6)
- CentAUR: Central Archive University of Reading - UK (18)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (57)
- Cochin University of Science & Technology (CUSAT), India (3)
- Coffee Science - Universidade Federal de Lavras (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Deakin Research Online - Australia (29)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (2)
- Digital Archives@Colby (1)
- Digital Commons - Michigan Tech (2)
- Digital Commons at Florida International University (5)
- Digital Repository at Iowa State University (1)
- DigitalCommons@The Texas Medical Center (21)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- Duke University (17)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (7)
- FUNDAJ - Fundação Joaquim Nabuco (2)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (10)
- Glasgow Theses Service (7)
- Helda - Digital Repository of University of Helsinki (14)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (57)
- Instituto Gulbenkian de Ciência (1)
- Instituto Nacional de Saúde de Portugal (1)
- Instituto Politécnico do Porto, Portugal (2)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- Massachusetts Institute of Technology (1)
- National Center for Biotechnology Information - NCBI (84)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Publishing Network for Geoscientific & Environmental Data (6)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (63)
- Queensland University of Technology - ePrints Archive (95)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório do Centro Hospitalar de Lisboa Central, EPE - Centro Hospitalar de Lisboa Central, EPE, Portugal (2)
- Repositório Institucional da Universidade de Aveiro - Portugal (2)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (95)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (3)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (4)
- Universidad Politécnica de Madrid (4)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (4)
- Universidade Federal do Pará (5)
- Universidade Federal do Rio Grande do Norte (UFRN) (6)
- Universita di Parma (2)
- Universitat de Girona, Spain (3)
- Université de Lausanne, Switzerland (12)
- Université de Montréal (2)
- Université de Montréal, Canada (22)
- Université Laval Mémoires et thèses électroniques (1)
- University of Michigan (3)
- University of Queensland eSpace - Australia (32)
- University of Washington (1)
- WestminsterResearch - UK (2)
Resumo:
The ability to appropriately interact with the environment is crucial to an organism’s survival. The establishment of functional sensory systems, such as the bristles and eyes in Drosophila, is a critical event during the development of the organism. The transcription factor D Pax2 is involved in the differentiation of the shaft and glial cells in the developing bristle (Kavaler et al., Dev, 126:2261-2272, 1999) and of the cone and primary pigment cells in the developing eye (Fu and Noll, Genes Dev, 11:389-405, 1997). How D-Pax2 contributes to distinct differentiative pathways in different cell types is not known. Recent work by Anna Czechowski and Katherine Harmon (personal communication) identified a mutation in the D-Pax2 gene that introduced a stop codon at the end of exon 9, effectively truncating the protein. This mutation affects bristle, but not eye, development. We thus suspected regions after exon 9 are required for D-Pax2 function only in the bristles and may also be associated with alternative splicing of the D Pax2 transcript. We plan to assess the role of the carboxy terminal region of the protein by establishing transgenic lines bearing rescue constructs of D-Pax2 with either the complete coding sequence or with deletions of specific exons. To date, we have generated the first rescue construct bearing the complete coding region of the gene driven by a 3 KB upstream regulatory region of D-Pax2 and are currently generating transgenic fly lines with this construct.