Effects of education on the therapeutic use of oxygen by emergency nurses

Nurses' factual knowledge increased and oxygen administration decisions improved following education. Variability in nurses' knowledge and decisions, both before and after education, suggests that factual knowledge is only one component of clinical decisions. If nursing education is to improve clinical practice, then we need to better understand the relationship between factual knowledge and clinical decisions.

Troubled minds: the lithium revolution

Ex-Changi prisoner of war, and psychiatrist, Dr John Cade, sought a pharmacological treatment for bipolar disorder in the 1940s ; and in so doing, marked the beginning of psychopharmacology.

Antihypertensive treatments obscure familial contributions to blood pressure variation

The linkage and association between inherent blood pressure and underlying genotype is potentially confounded by antihypertensive treatment. We estimated blood pressure variance components (genetic, shared environmental, individual-specific) in 767 adult volunteer families by using a variety of approaches to adjusting blood pressure of the 244 subjects (8.2%) receiving antihypertensive medications. The additive genetic component of variance for systolic pressure was 73.9 mm Hg(2) (SE, 8.8) when measured pressures (adjusted for age by gender within each generation) were used but fell to 61.4 mm Hg(2) (SE, 8.0) when treated subjects were excluded. When the relevant 95th percentile values were substituted for treated systolic pressures, the additive genetic component was 81.9 mm Hg(2) (SE, 9.5), but individual adjustments in systolic pressure ranged from -53.5 mm Hg to +64.5 mm Hg (mean, +17.2 mm Hg). Instead, when 10 mm Hg was added to treated systolic pressure, the additive genetic component rose to 86.6 mm Hg(2) (SE, 10.1). Similar changes were seen in the shared environment component of variance for systolic pressure and for the combined genetic and shared environmental (ie, familial) components of diastolic pressure. There was little change in the individual-specific variance component across any of the methods. Therefore, treated subjects contribute important information to the familial components of blood pressure variance. This information is lost if treated subjects are excluded and obscured by treatment effects if unadjusted measured pressures are used. Adding back an appropriate increment of pressure restores familial components, more closely reflects the pretreatment values, and should increase the power of genomic linkage and linkage disequilibrium analyses.

Identification and characterisation of novel compound(s) for the treatment of type 2 diabetes

The thesis shows that a plant extract favourably affects glucose utilisation and production in vitro, and identifies genes/biological pathways involved in its actions. The extract underwent fractionation and screening for effects observed. Chemical studies of active fractions led to the isolation of a compound shown to have potential anti-diabetic properties.

Meaning in life during midlife development

The thesis findings revealed midlife adults see meaning in life as comprising life philosophy / value, and purpose / reason, which guide and direct, and help to make sense of and cope with life. These aspects of life meaning are relevant but add unique contributions to a more global sense of meaning in life. The clinical portfolio explores the role of play in psychotherapy with children. Four case studies illustrate various ways in which play can be incorporated into therapeutic practice according to the child client's circumstances.

Changing spaces

Using Gidden's structuration theory to explore marginalised young people's perceptions of a six-week outdoor experiential program, this study uncovers the processes involved in increasing the agency and control the young people have over their future health and wellbeing to enable them to make significant changes in their life styles.

Companion animal visitation and its effectiveness with stroke patients

The study employed a randomised controlled trial design to determine whether a companion animal intervention had any effect on wellbeing and quality of life in patients who were admitted to hospital after suffering a stroke. The study found significant benefits for their wellbeing and improvements in quality of life.

Wild adventures in wellbeing

This study examined the foundations, features and wellbeing impacts of Australian outdoor adventure interventions (OAI). According to literature- and practice-based evidence, Australian OAI support positive impacts for individuals across physical, emotional, behavioural, social, cultural, spiritual, economic and environmental wellbeing in the Australian context.

Hormonal breast and prostate cancer cytotoxic agents

Details 13 novel hormone compounds, designed and synthesised for the purpose of aiding the detection and treatment of breast and prostate cancers. Cellular and electromechanical studies of 3 of these synthesised hormones indicate a potential for human application.

Assessment of shark cartilage extract from two commercially viable species

This study provided initial evidence that extract derived from the cartilage of two commercially available Australian shark species, may potentially, be effective in the inhibition of tumour growth, whilst also showing that the species and maturity level, but not the gender of the shark, influenced the amount of extract obtained.

The role of positive irrational beliefs in mental health & wellbeing

This research found that positive irrational beliefs can be separated into distinct categories. These categories only had weak power for explaining aspects of mental health, including emotional state, satisfaction with life, and self-esteem. The direction of these relationships also varied according to the specific positive irrational beliefs being examined. The portfolio presents four case studies to examine the importance of a biopsychosocial model of health and concludes that all health professionals need an understanding of the potential interactions impacting on individuals' experiences with particular conditions.

Managing constipation in older people

The study consists of two parts: a systematic review that critically analysed existing Chinese medicine clinical trials in managing constipation and, a cluster randomised controlled trial investigating the effects of education and acupressure on constipation in older people. Participants in the experimental group reported significant improvements in their constipation symptoms.