Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function

BACKGROUND: Flavonoids may be partly responsible for some health benefits, including antiinflammatory action and a decreased tendency for the blood to clot. An acute dose of flavanols and oligomeric procyanidins from cocoa powder inhibits platelet activation and function over 6 h in humans. OBJECTIVE: This study sought to evaluate whether 28 d of supplementation with cocoa flavanols and related procyanidin oligomers would modulate human platelet reactivity and primary hemostasis and reduce oxidative markers in vivo. DESIGN: Thirty-two healthy subjects were assigned to consume active (234 mg cocoa flavanols and procyanidins/d) or placebo (< or = 6 mg cocoa flavanols and procyanidins/d) tablets in a blinded parallel-designed study. Platelet function was determined by measuring platelet aggregation, ATP release, and expression of activation-dependent platelet antigens by using flow cytometry. Plasma was analyzed for oxidation markers and antioxidant status. RESULTS: Plasma concentrations of epicatechin and catechin in the active group increased by 81% and 28%, respectively, during the intervention period. The active group had significantly lower P selectin expression and significantly lower ADP-induced aggregation and collagen-induced aggregation than did the placebo group. Plasma ascorbic acid concentrations were significantly higher in the active than in the placebo group (P < 0.05), whereas plasma oxidation markers and antioxidant status did not change in either group. CONCLUSIONS: Cocoa flavanol and procyanidin supplementation for 28 d significantly increased plasma epicatechin and catechin concentrations and significantly decreased platelet function. These data support the results of acute studies that used higher doses of cocoa flavanols and procyanidins.

Theobroma cacao (cocoa) supplementation in the treatment of Non-alcoholic Steatohepatitis

Non-alcoholic Steatohepatitis (NASH) is a chronic disease that results from accumulation of fat within the liver that subsequently stimulates free radicals to damage the cells of the liver. Cocoa is a rich source of antioxidants and it was found that its consumption could slow the development of NASH.

Fundacion Maquipucuna: an entrepreneurial Ecuadorian non-profit organisation

The purpose of this paper is to describe Fundacion Maquipucuna's community-based entrepreneurship activities. Fundacion Maquipucuna is a unique non-profit organisation in the Choco-Andes region of Ecuador. An ethnographic study and review of the literature is conducted to analyse the cacao, coffee, ecotourism and plastic thatch enterprises of Fundacion Maquipucuna. The enterprises Fundacion Maquipucuna is engaged in support the ongoing sustainability of the biodiverse ecological environment in the Choco-Andes region, which is one of the top five biodiverse hotspots in the world. On a global scale, more emphasis is being placed on promoting sustainability initiatives to preserve the environment. This paper discusses how a litre-government agency Fundacion Maquipucuna is changing from a non-profit to a for-profit structure in order to continue its community engagement projects. This paper integrates the social and community-based entrepreneurship literature to discuss how Fundacion Maquipucuna is engaging in innovative regional development that benefits the whole Choco-Andes community including the large Afro-Ecuadorian population.