China's aircraft carrier ambitions

Focuses on the intent of the Chinese government to acquire an aircraft carrier force as part of its ambition to achieve high seas naval capability. Possibility of buying a light aircraft carrier from a European builder; Concerns over the possibility to operate aircraft carrier battle groups; Protection of sovereignty and maritime resources.

Carrier's liability under the Hague, Hague-Visby and Hamburg Rules

Provides a critical analysis of the carrier's liability under the Hague, Hague-Visby and Hamburg Rules. Focusing on Australian and English jurisprudence, the work also demonstrates that, quite contrary to prevailing opinions, the Hamburg Rules do not materially change (still less increase) the carrier's existing liability.

Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization

A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.

Formulation optimization for high drug loading colonic drug delivery carrier

High drug loading (DL) carrier is an effective way to cure the cancerous cells. High drug loading is also one of the key issues in the drug delivery research, especially the colonic drug delivery system by oral administration. The times of drug intake could be remarkably reduced if high drug loading carriers are administered. At the same time, the related formulation materials could be effectively utilized. One major obstacle with the preparation of this system is the difficulty to encapsulate the hydrophilic drug into hydrophobic encapsulation polymer. A design of high drug loading delivery system with biodegradable, biocompatible materials and optimization of the fabrication process is a potential solution to solve the problem. So in this research, 5-Fluorouracil (5-FU) loaded Poly (lactide-co-glycolide) (PLGA) nanoparticles were prepared by double emulsion and solvent evaporation method. Several fabrication parameters including theoretical drug loading, volume ratio of outer water phase to the first emulsion, pH value of outer aqueous phase and emulsifier PVA concentration were optimized to get a high drug loading nanoparticles. The result shows that with the increase of theoretical drug loading, the actual drug loading increased gradually. When adjusted the pH value of outer aqueous phase to the isoelectric point (8.02) of 5-Fluorouracil, the drug loading exhibited a higher one compared to other pH value solution. Relative higher volume ratio of outer water phase to the first emulsion was also beneficial for the enhancement of drug loading. But the nanoparticles size increased simultaneously due to the lower shearing force. When increased the PVA concentration, the drug loading showed an increase first and following a drop.

The interrelationship between the accumulation of lipids, protein and the level of acyl carrier protein during the development of Brassica napus L. pollen

Lipid accumulation during pollen and tapetal development was studied using cryostat sections of unfixed anthers from Brassica napus (rapeseed). Diamidino-2-henylindole (DAPI), a DNA fluorochrome, was used to stain the pollen nuclei in order to identify ten stages of pollen development in Brassica. Storage lipids (i.e. triacylglycerides) were stained using the fluorochrome Nile red. Pollen coat lipids are formed in tapetal plastids between the mid-vacuolate and early maturation pollen stages. The pollen coat components, including lipids and a proportion of the proteins, are derived from the remnants of the tapetum, after its rupture, during the second pollen mitosis. Quantitative microfluorometric analyses demonstrated four phases of lipid body accumulation or depletion in the developing pollen cytoplasm. The majority of storage lipids found in the cytoplasm of the mature pollen grain accumulated during the late vacuolate and early maturation stages when the pollen is bicellular. The level of acyl carrier protein, a protein integrally involved in lipid synthesis, was also found to be maximal in the developing pollen during the bicellular pollen stages of development. This coincided with the most active period of lipid accumulation. These data could indicate that the lipids of the pollen are synthesized in situ, by metabolic processes regulated by expression of genes in the haploid genome.

Silk as novel nano-carrier for delivering anti-cancer biomolecule lactoferrin

Anti-cancer bio-molecule lactoferrin and silk as a novel nano-carrier showed the promising outcome for the treatment of Breast cancer.

Offering fragile X syndrome carrier screening: a prospective mixed-methods observational study comparing carrier screening of pregnant and non-pregnant women in the general population

Article focus
▪ This article is a protocol of a study that involves offering fragile X syndrome carrier screening to pregnant and non-pregnant women in the general population. We are undertaking a programme evaluation approach using mixed methods to collect data about informed decisionmaking and predictors of test uptake, with a focus on psychosocial measures. We are also undertaking an economic appraisal.

Security considerations for wireless carrier agonistic bio-monitoring systems

Advances in information and communications technology has led to a significant advances in noncontact portable devices capable of monitoring vital signals of patients. These wearable and implantable bio-monitoring systems allow collections of wearable sensors to be constructed as a Body Area Network (BAN) to record biological data for a subject. Such systems can be used to improve the quality of life and treatment outcomes for patients. One of the main uses for a bio-monitoring system is to record biological data values from a subject and provide them to a doctor or other medical professional. However, wearable bio-monitoring systems raise unique security considerations. In this paper, we discuss some of the security considerations that have arisen in our work around communications agnostic bio-monitoring, and how we have addressed these concerns. Furthermore, the issues related to the identifying and trusting sender and receiver entities are discussed.

Software-defined carrier wireless networks

The telecommunication industry is entering a new era. The increased traffic demands imposed by the huge number of always-on connections require a quantum leap in the field of enabling techniques. Furthermore, subscribers expect ever increasing quality of experience with its joys and wonders, while network operators and service providers aim for cost-efficient networks. These requirements require a revolutionary change in the telecommunications industry, as shown by the success of virtualization in the IT industry, which is now driving the deployment and expansion of cloud computing. Telecommunications providers are currently rethinking their network architecture from one consisting of a multitude of black boxes with specialized network hardware and software to a new architecture consisting of “white box” hardware running a multitude of specialized network software. This network software may be data plane software providing network functions virtualization (NVF) or control plane software providing centralized network management — software defined networking (SDN). It is expected that these architectural changes will permeate networks as wide ranging in size as the Internet core networks, to metro networks, to enterprise networks and as wide ranging in functionality as converged packet-optical networks, to wireless core networks, to wireless radio access networks.