243 resultados para HDL Function


Relevância:

30.00% 30.00%

Publicador:

Resumo:

Exotic flora, particularly weeds, are renowned for out-competing and displacing native flora, consequently affecting native fauna and pollinator relationships. Nonetheless, it stands to reason that weeds must provide some compensatory ecological value. This study assessed whether weeds are friend or foe to ecosystem function by considering the quality and quantity of pollen offered by widespread weeds in Australian ecosystems. Using the Honeybee Apis mellifera as a case study, and information derived from highly experienced commercial apiarists, we determined that 32 exotic plants are important pollen sources. Most species offered high to very high quality pollen. Pollen quality varied temporally, spatially and infraspecifically. Fifteen species were considered more beneficial to A. mellifera than others; only seven species were considered less beneficial. Thus, exotic flora contribute pollen resources that are valuable to maintain ecosystem function, particularly at times when flowering native species are few.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

In this paper, we identify the necessary capabilities of the IT function to create agility in existing information systems. Agility is the ability to quickly sense and respond to environment perturbations. We contrast the agility perspective from a widely used industry framework with research perspectives on agility in the IS literature. We suggest Beer’s Viable System Model (VSM) is a useful meta-level theory to house agility elements from IS research literature, and apply VSM principles to identify the capabilities required of the IT function. Indeed, by means of a survey of 34 organisations, we confirm that the meta-level theory better correlates with reported agility measures than existing practice measures do on their own. From a research perspective, the incorporation of the VSM mechanism helps to explain ‘why’ the IT function is capable of creating agility. From a practical perspective of ‘how’, the findings point to a new set of capabilities of the IT function for future versions of the industry frameworks to enable agility.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

This research identifies how the IT function can create agility in existing information systems. Agility is the capability to quickly sense and respond to environmental perturbations. We contrasted perspectives on agility from a widely used industry framework and that of the IS research literature. Beer’s Viable System Model was a useful meta-level theory to house agility elements from IS research and it introduced cybernetic principles to identify the processes required of the IT function. Indeed, our surveys of 70 organizations confirmed that the applied theory better correlates with reported agility than does existing industry best practice.

The research conducted two quantitative surveys to test the applied theory. The first survey mailed a Likert-type questionnaire to the clients of an Australian IT consultancy. The second survey invited international members of professional interest groups to complete a web-based questionnaire. The responses from the surveys were analyzed using partial-least-squares modeling. The data analysis positively correlated the maturity of IT function processes prescribed by the VSM and the likelihood of agility in existing information systems. We claim our findings generalize to other large organizations in OECD member countries.

The research offers an agility-capability model of the IT function to explain and predict agility in existing information systems. A further contribution is to improve industry ‘best practice’ frameworks by prescribing processes of the IT function to develop in maturity.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

An enhanced macromolecular nanofiber network and its implications have been developed by employing the understanding of its formation with an emphasis on its topological aspect. Using agarose aqueous solution as a typical example, the macromolecular nanofiber network of soft functional materials has been clearly visualized for the first time using the developed technique of field emission scanning electronic microscopy coupled with flash-freeze-drying. Both the systematic kinetic study and the image evidence indicates that the nanofiber network in soft functional materials such as agarose turns out to form through a self-expitaxial nucleation-controlled process. This new understanding enables us to engineer ultra functions of soft materials via nanofiber network architecture, which in turn opens up a new direction in nano fabrication.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

The ordered weighted averaging (OWA) determination method with stress function was proposed by Yager, and it makes the OWA operator elements scatter in the shape of the stress function. In this paper, we extend the OWA determination with the stress function method using an optimization model. The proposed method transforms the OWA optimal solution elements into the interpolation points of the stress function. The proposed method extends the basic form of the stress function method with both scale and vertical shift transformations.We also explore a number of properties of this optimization-based stress function method. The OWA operator optimal solution elements can distribute as the shape of the given stress function in a parameterized way, in which case, the solution always possesses the arithmetic average operator as a special case.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

Receptor activity-modifying proteins (RAMPs) interact with and modify the behavior of the calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR). We have examined the contribution of the short intracellular C terminus, using constructs that delete the last eight amino acids of each RAMP. C-Terminal deletion of individual RAMPs had little effect on the signaling profile induced when complexed with CLR in COS-7 or human embryonic kidney (HEK)293 cells. Likewise, confocal microscopy revealed each of the mutant RAMPs translocated hemagglutinin-tagged CLR to the cell surface. In contrast, a pronounced effect of RAMP C-terminal truncation was seen for RAMP/CTRa complexes, studied in COS-7 cells, with significant attenuation of amylin receptor phenotype induction that was stronger for RAMP1 and -2 than RAMP3. The loss of amylin binding upon C-terminal deletion could be partially recovered with overexpression of Gαs, suggesting an impact of the RAMP C terminus on coupling of G proteins to the receptor complex. In HEK293 cells the c-Myc-RAMP1 C-terminal deletion mutant showed high receptor-independent cell surface expression; however, this construct showed low cell surface expression when expressed alone in COS-7 cells, indicating interaction of RAMPs with other cellular components via the C terminus. This mutant also had reduced cell surface expression when coexpressed with CTR. Thus, this study reveals important functionality of the RAMP C-terminal domain and identifies key differences in the role of the RAMP C terminus for CTR versus CLR-based receptors.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

The latent structure of a 16-item mentoring function instrument was analyzed with the responses of 568 full-time employees. Features of the analyses included (a) assessment of the items' distributional properties (i.e., skewness and kurtosis); (b) assessment of the factor structure using the Satorra-Bentler scaled test statistic; and (c) evaluation of the instrument's invariance across sex. Confirmatory factor analyses using the scaled chi-square supported a two-factor oblique model that consisted of psychosocial and career-related mentoring functions. The invariance tests suggested that the structure was invariant across sex groups.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

Some evidence suggests that sedentary behaviour is independently associated with cardiovascular (CV) risk. Endothelial dysfunction is the earliest detectable manifestation of CVD and a strong independent predictor of CV events. No previous study has examined the relationship between sedentary behaviour and endothelial function. We assessed the basal association between conduit artery endothelial function and sedentary behaviour in children, along with the correlation between changes in sedentary behaviour and endothelial function. We studied 116 children (70$: 10.7 ± 0.3; 46#: 10.7 ± 0.3 years) on two occasions; in the summer (June) and late autumn (November). We assessed endothelial function via flowmediated dilation (FMD) using high-resolution Doppler ultrasound. Sedentary behaviour (SB) was assessed using objective uni-axial accelerometry. At baseline, there were no significant differences between girls and boys for any measured variables with the exception of total physical activity time. FMD was not associated with sedentary behaviour in either group or in the cohort as a whole. Although FMD decreased (10.0 ± 4.3–7.9 ± 3.9%, P\0.001) and SB increased (499.1 ± 103.5–559 ± 81.6 min/day, P\0.001) between the seasons, no relationship existed between changes in these variables. Our data suggest that sedentary behaviour and changes in sedentary behaviour are not associated with endothelial function in children.

Relevância:

30.00% 30.00%

Publicador:

Resumo:

The epidemiology and sequelae of morphometric vertebral fracture (MVF) are poorly documented. We found that MVFs of the lower thoracic and lumbar spine were associated with poor quality of life and impaired physical function in men. We recommend that morphometric X-ray absorptiometry be included in routine requests for bone densitometry.