Epigenetics and autoimmune diseases

Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucleosome positioning, and microRNAs (miRNAs) are essential to carry out key functions in the regulation of gene expression. Therefore, the epigenetic mechanisms are a window to understanding the possible mechanisms involved in the pathogenesis of complex diseases such as autoimmune diseases. It is noteworthy that autoimmune diseases do not have the same epidemiology, pathology, or symptoms but do have a common origin that can be explained by the sharing of immunogenetic mechanisms. Currently, epigenetic research is looking for disruption in one or more epigenetic mechanisms to provide new insights into autoimmune diseases. The identification of cell-specific targets of epigenetic deregulation will serve us as clinical markers for diagnosis, disease progression, and therapy approaches.

Modification of personality variables through application of a psycho-educational program of full consciousness (mindfulness) in university students

This study examines the effects in university students of a psycho-educational program in full awareness (mindfulness) on certain personality variables. A quasi-experimental (group comparison) design with pretest and postest measurements was employed in an experimental (n = 26) and a control group (n = 27). Barratt impulsiveness Scale (BiS- 11), Acceptance and Action Questionnaire (AAQ), Social Avoidance and Distress Scale (SAD), and the Profile of Mood States (POMS) were applied to experimental and control groups. The results show statistically significant changes in impulsivity variables, experiential avoidance, social avoidance, social anxiety, tension and fatigue when comparing the posttest mean scores of the groups.