1 resultado para High-fat diet
em Universitat de Girona, Spain
Filtro por publicador
- Aberdeen University (3)
- Abertay Research Collections - Abertay University’s repository (2)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (2)
- Aquatic Commons (14)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (9)
- Aston University Research Archive (9)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (5)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (39)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (28)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (52)
- Bioline International (5)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (44)
- Brock University, Canada (7)
- Bucknell University Digital Commons - Pensilvania - USA (3)
- CentAUR: Central Archive University of Reading - UK (69)
- Centro Hospitalar do Porto (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (4)
- Cochin University of Science & Technology (CUSAT), India (2)
- CORA - Cork Open Research Archive - University College Cork - Ireland (8)
- Dalarna University College Electronic Archive (1)
- Digital Commons at Florida International University (5)
- Digital Repository at Iowa State University (2)
- DigitalCommons@The Texas Medical Center (13)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (8)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (11)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Glasgow Theses Service (1)
- Helda - Digital Repository of University of Helsinki (16)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (5)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (11)
- Publishing Network for Geoscientific & Environmental Data (1)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (28)
- Queensland University of Technology - ePrints Archive (69)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional da Universidade de Brasília (2)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (198)
- Research Open Access Repository of the University of East London. (1)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- Scielo España (2)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (4)
- Universidad Politécnica de Madrid (4)
- Universidade de Lisboa - Repositório Aberto (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal do Pará (1)
- Universitat de Girona, Spain (1)
- Université de Lausanne, Switzerland (9)
- Université de Montréal (4)
- Université de Montréal, Canada (35)
- Université Laval Mémoires et thèses électroniques (2)
- University of Connecticut - USA (1)
- University of Michigan (4)
- University of Queensland eSpace - Australia (14)
- University of Washington (4)
- Worcester Research and Publications - Worcester Research and Publications - UK (4)
Resumo:
To gain insight in the relationship between innate immune system and metabolic disease, we aimed to investigate the effects of lactoferrin in obesity-related metabolic disturbances. Circulating lactoferrin concentration was significantly decreased in subjects with altered glucose tolerance (AGT) and associated negatively with obesity-related metabolic disturbances. The SNPs-induced aminoacidic changes in lactoferrin N-terminus region were associated with a low atherogenic lipid profile. Lactoferrin production in neutrophils decreased significatively in aging, chronic low-grade inflammation and type 2 diabetes. In vitro, lactoferrin increased insulin signaling pathway, even under insulin resistance conditions and displayed dual effects on adipogenesis (antiadipogenic in 3T3-L1 and adipogenic in human adipocytes). In conclusion, lactoferrin might play a potential protective role against insulin resistance and obesity related metabolic disturbances.