Neuroreceptor availability and cerebral morphology in human obesity

Obesity is a major challenge to human health worldwide. Little is known about the brain mechanisms that are associated with overeating and obesity in humans. In this project, multimodal neuroimaging techniques were utilized to study brain neurotransmission and anatomy in obesity. Bariatric surgery was used as an experimental method for assessing whether the possible differences between obese and non-obese individuals change following the weight loss. This could indicate whether obesity-related altered neurotransmission and cerebral atrophy are recoverable or whether they represent stable individual characteristics. Morbidly obese subjects (BMI ≥ 35 kg/m2) and non-obese control subjects (mean BMI 23 kg/m2) were studied with positron emission tomography (PET) and magnetic resonance imaging (MRI). In the PET studies, focus was put on dopaminergic and opioidergic systems, both of which are crucial in the reward processing. Brain dopamine D2 receptor (D2R) availability was measured using [11C]raclopride and µ-opioid receptor (MOR) availability using [11C]carfentanil. In the MRI studies, voxel-based morphometry (VBM) of T1-weighted MRI images was used, coupled with diffusion tensor imaging (DTI). Obese subjects underwent bariatric surgery as their standard clinical treatment during the study. Preoperatively, morbidly obese subjects had significantly lower MOR availability but unaltered D2R availability in several brain regions involved in reward processing, including striatum, insula, and thalamus. Moreover, obesity disrupted the interaction between the MOR and D2R systems in ventral striatum. Bariatric surgery and concomitant weight loss normalized MOR availability in the obese, but did not influence D2R availability in any brain region. Morbidly obese subjects had also significantly lower grey and white matter densities globally in the brain, but more focal changes were located in the areas associated with inhibitory control, reward processing, and appetite. DTI revealed also signs of axonal damage in the obese in corticospinal tracts and occipito-frontal fascicles. Surgery-induced weight loss resulted in global recovery of white matter density as well as more focal recovery of grey matter density among obese subjects. Altogether these results show that the endogenous opioid system is fundamentally linked to obesity. Lowered MOR availability is likely a consequence of obesity and may mediate maintenance of excessive energy uptake. In addition, obesity has adverse effects on brain structure. Bariatric surgery however reverses MOR dysfunction and recovers cerebral atrophy. Understanding the opioidergic contribution to overeating and obesity is critical for developing new psychological or pharmacological treatments for obesity. The actual molecular mechanisms behind the positive change in structure and neurotransmitter function still remain unclear and should be addressed in the future research.

Palkitsemisen vaikutus kaupan alan myymälähenkilökunnan työmotivaatioon ja työsuoritukseen

Palkitseminen on yksi keskeisimmistä työmotivaatioon ja työsuoritukseen vaikuttavista elementeistä. Tässä kvalitatiivisella tutkimusmenetelmällä laaditussa Pro gradu-tutkielmassa tutkitaan palkitsemisen vaikutusta kaupan alan myymälähenkilökunnan työmotivaatioon ja työsuoritukseen. Tutkimuksen tavoitteena on selvittää millä tutki-muksen kohdeorganisaation nykyisillä kokonaispalkitsemisen keinoista on merkittävin vaikutus myymälähenkilökunnan työmotivaatioon ja työsuoritukseen. Lisäksi tutkimus havinnollistaa, millaisilla muilla palkitsemisen keinoilla pystytään vaikuttamaan myymälähenkilökunnan työmotivaatioon siten, että sen vaikutus heijastuu positiivisena impulssina myös työntekijän työsuoritukseen. Tutkimuksen teoreettinen viitekehys on rakennettu kokonaispalkitsemisen ja työmotivaation ympärille ja näkökulmia peilataan sekä yksilön kokeman oikeudenmukaisuuden, että yrityksen strategisen palkitsemisen näkökulmista. Tutkimuksen perusteella voidaan nähdä, että tulokseen sidottu palkitseminen on yksi keskeisimmistä työsuoritukseen vaikuttavista palkitsemisen elementeistä myyntityössä. Työsuoritukseen ja työmotivaatioon pystytään vaikuttamaan myös itsenäisellä työskentelytavalla, uramahdollisuuksilla ja ammatillisen kehittymisen mahdollisuuksilla. Kohdeorganisaation kokonaispalkitsemisen mallia tulisikin muokata vastaamaan entistä paremmin näitä indikaattoreita, jotta kokonaispalkitsemisen malli toimisi strategisen palkitsemisen näkökulmasta mahdollisimman optimaalisella tavalla.

Attraction, recruitment and retention of high performing sales professionals case study: Lindström

The goal of this thesis is to gain more in-depth understanding of employer branding and offer suggestions on how this knowledge could be utilized in the case company. More in detail, the purpose of this research is to provide tools for improving Lindström’s organizational attractiveness and boosting the recruitment and retention of the segment of high-performing sales professionals. A strategy for reaching this particular segment has not been previously drawn and HR-managers believe strongly that it would be very beneficial for the company’s development and growth. The topic of this research is very current for Lindström, but also contributes on general level as companies are competing against each other in attracting, recruiting and retention of skilled workforce in the times of labor shortage. The research is conducted with qualitative methods and the data collection includes primary data through interviews as well as secondary data in the form of analysis on previous research, websites, recruitment material and discussions with Lindström’s HR department. This research provides a good basis for broader examination on the topic and presents development suggestions for the identified challenges. Based on the key findings Lindström’s HR department was advised to increase firm’s visibility, broaden recruitment channels, provide more hands-on knowledge about the sales positions and investigate their possibilities of developing sales reward systems.