166 resultados para Bcl-2 family
Filtro por publicador
- Aberdeen University (2)
- Aberystwyth University Repository - Reino Unido (1)
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- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (6)
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- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (12)
- Archive of European Integration (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (4)
- Aston University Research Archive (5)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (3)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (21)
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- Bioline International (5)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (48)
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- Brock University, Canada (14)
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- CentAUR: Central Archive University of Reading - UK (10)
- Center for Jewish History Digital Collections (23)
- Chapman University Digital Commons - CA - USA (1)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (40)
- Clark Digital Commons--knowledge; creativity; research; and innovation of Clark University (1)
- Coffee Science - Universidade Federal de Lavras (1)
- Cor-Ciencia - Acuerdo de Bibliotecas Universitarias de Córdoba (ABUC), Argentina (1)
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- Deakin Research Online - Australia (28)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
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- Duke University (16)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (4)
- FAUBA DIGITAL: Repositorio institucional científico y académico de la Facultad de Agronomia de la Universidad de Buenos Aires (2)
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- Helda - Digital Repository of University of Helsinki (20)
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- Indian Institute of Science - Bangalore - Índia (37)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Politécnico de Bragança (2)
- Instituto Politécnico de Viseu (2)
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- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (5)
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- National Center for Biotechnology Information - NCBI (64)
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- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (84)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- School of Medicine, Washington University, United States (3)
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- Universidade Federal do Rio Grande do Norte (UFRN) (6)
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- Universita di Parma (1)
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- Université de Lausanne, Switzerland (9)
- Université de Montréal (9)
- Université de Montréal, Canada (34)
- University of Michigan (6)
- University of Queensland eSpace - Australia (19)
- University of Southampton, United Kingdom (1)
- University of Washington (3)
- WestminsterResearch - UK (1)
Resumo:
Retinal angiogenesis is tightly regulated to meet oxygenation and nutritional requirements. In diseases such as proliferative diabetic retinopathy and neovascular age-related macular degeneration, uncontrolled angiogenesis can lead to blindness. Our goal is to better understand the molecular processes controlling retinal angiogenesis and discover novel drugs that inhibit retinal neovascularization. Phenotype-based chemical screens were performed using the ChemBridge DiversetTM library and inhibition of hyaloid vessel angiogenesis in Tg(fli1:EGFP) zebrafish. 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol, (quininib) robustly inhibits developmental angiogenesis at 4–10 μM in zebrafish and significantly inhibits angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants, and retinal revascularization in oxygen-induced retinopathy mice. Quininib is well tolerated in zebrafish, human cell lines, and murine eyes. Profiling screens of 153 angiogenic and inflammatory targets revealed that quininib does not directly target VEGF receptors but antagonizes cysteinyl leukotriene receptors 1 and 2 (CysLT1–2) at micromolar IC50 values. In summary, quininib is a novel anti-angiogenic small-molecule CysLT receptor antagonist. Quininib inhibits angiogenesis in a range of cell and tissue systems, revealing novel physiological roles for CysLT signaling. Quininib has potential as a novel therapeutic agent to treat ocular neovascular pathologies and may complement current anti-VEGF biological agents.