16 resultados para Quantitative-analysis
Filtro por publicador
- JISC Information Environment Repository (1)
- Aberystwyth University Repository - Reino Unido (2)
- Academic Archive On-line (Stockholm University; Sweden) (1)
- Academic Research Repository at Institute of Developing Economies (2)
- Adam Mickiewicz University Repository (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (2)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (3)
- Aquatic Commons (13)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (3)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (5)
- Aston University Research Archive (14)
- B-Digital - Universidade Fernando Pessoa - Portugal (3)
- Biblioteca Digital da Câmara dos Deputados (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (10)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (20)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (22)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (37)
- Boston University Digital Common (2)
- Brock University, Canada (7)
- CaltechTHESIS (3)
- Cambridge University Engineering Department Publications Database (8)
- CentAUR: Central Archive University of Reading - UK (43)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (75)
- Cochin University of Science & Technology (CUSAT), India (6)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (7)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (60)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (3)
- Digital Archives@Colby (1)
- Digital Commons - Michigan Tech (1)
- Digital Commons at Florida International University (5)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (1)
- Duke University (5)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (1)
- FUNDAJ - Fundação Joaquim Nabuco (1)
- Glasgow Theses Service (1)
- Greenwich Academic Literature Archive - UK (2)
- Helda - Digital Repository of University of Helsinki (16)
- Hospitais da Universidade de Coimbra (1)
- Indian Institute of Science - Bangalore - Índia (15)
- Instituto Politécnico do Porto, Portugal (16)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- Martin Luther Universitat Halle Wittenberg, Germany (1)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (11)
- Nottingham eTheses (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (1)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (7)
- QSpace: Queen's University - Canada (1)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (53)
- Queensland University of Technology - ePrints Archive (75)
- RDBU - Repositório Digital da Biblioteca da Unisinos (1)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (5)
- Repositório Científico da Universidade de Évora - Portugal (3)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (6)
- Repositório digital da Fundação Getúlio Vargas - FGV (18)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (3)
- Repositorio Institucional da UFLA (RIUFLA) (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (7)
- Repositório Institucional dos Hospitais da Universidade Coimbra (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (215)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (6)
- SAPIENTIA - Universidade do Algarve - Portugal (2)
- School of Medicine, Washington University, United States (1)
- Universidad de Alicante (3)
- Universidad del Rosario, Colombia (24)
- Universidad Politécnica de Madrid (7)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade Federal do Pará (1)
- Universidade Federal do Rio Grande do Norte (UFRN) (33)
- Universidade Técnica de Lisboa (2)
- Universitat de Girona, Spain (2)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (3)
- Université de Lausanne, Switzerland (4)
- Université de Montréal, Canada (18)
- Université Laval Mémoires et thèses électroniques (1)
- University of Connecticut - USA (1)
- University of Michigan (8)
- University of Queensland eSpace - Australia (9)
- University of Southampton, United Kingdom (1)
- University of Washington (1)
Resumo:
Several of the newly developed drug molecules experience poor biopharmaceutical behavior, which hinders their effective delivery at the proper site of action. Among the several strategies employed in order to overcome this obstacle, mesoporous silicon-based materials have emerged as promising drug carriers due to their ability to improve the dissolution behavior of several poorly water-soluble drugs compounds confined within their pores. In addition to improve the dissolution behavior of the drugs, we report that porous silicon (PSi) nanoparticles have a higher degree of biocompatibility than PSi microparticles in several cell lines studied. In addition, the degradation of the nanoparticles showed its potential to fast clearance in the body. After oral delivery, the PSi particles were also found to transit the intestines without being absorbed. These results constituted the first quantitative analysis of the behavior of orally administered PSi nanoparticles compared with other delivery routes in rats. The self-assemble of a hydrophobin class II (HFBII) protein at the surface of hydrophobic PSi particles endowed the particles with greater biocompatibility in different cell lines, was found to reverse their hydrophobicity and also protected a drug loaded within its pores against premature release at low pH while enabling subsequent drug release as the pH increased. These results highlight the potential of HFBII-coating for PSi-based drug carriers in improving their hydrophilicity, biocompatibility and pH responsiveness in drug delivery applications. In conclusion, mesoporous silicon particles have been shown to be a versatile platform for improving the dissolution behavior of poorly water-soluble drugs with high biocompatibility and easy surface modification. The results of this study also provide information regarding the biofunctionalization of the THCPSi particles with a fungal protein, leading to an improvement in their biocompatibility and endowing them with pH responsive and mucoadhesive properties.