1 resultado para Intracellular trafficking
em Universidade Complutense de Madrid
Filtro por publicador
- KUPS-Datenbank - Universität zu Köln - Kölner UniversitätsPublikationsServer (1)
- Aberdeen University (4)
- Abertay Research Collections - Abertay University’s repository (3)
- Academic Research Repository at Institute of Developing Economies (4)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- ARCA - Repositório Institucional da FIOCRUZ (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (9)
- Archive of European Integration (9)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (8)
- Aston University Research Archive (23)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (18)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (9)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (88)
- Brock University, Canada (5)
- CaltechTHESIS (1)
- Cambridge University Engineering Department Publications Database (6)
- CentAUR: Central Archive University of Reading - UK (29)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (19)
- Cochin University of Science & Technology (CUSAT), India (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (10)
- CORA - Cork Open Research Archive - University College Cork - Ireland (4)
- Cornell: DigitalCommons@ILR (1)
- Deakin Research Online - Australia (58)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (10)
- DigitalCommons@The Texas Medical Center (34)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (7)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (2)
- Greenwich Academic Literature Archive - UK (2)
- Harvard University (2)
- Helda - Digital Repository of University of Helsinki (17)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (30)
- Instituto Nacional de Saúde de Portugal (2)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Memorial University Research Repository (1)
- National Center for Biotechnology Information - NCBI (128)
- Nottingham eTheses (2)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (3)
- Publishing Network for Geoscientific & Environmental Data (6)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (87)
- Queensland University of Technology - ePrints Archive (155)
- Repositório Institucional da Universidade de Aveiro - Portugal (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (20)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (5)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (2)
- School of Medicine, Washington University, United States (5)
- Universidad de Alicante (3)
- Universidad del Rosario, Colombia (2)
- Universidad Politécnica de Madrid (1)
- Universidade Complutense de Madrid (1)
- Universidade de Lisboa - Repositório Aberto (1)
- Universita di Parma (1)
- Universitat de Girona, Spain (2)
- Université de Lausanne, Switzerland (5)
- Université de Montréal (5)
- Université de Montréal, Canada (16)
- University of Michigan (4)
- University of Queensland eSpace - Australia (43)
- University of Washington (3)
- WestminsterResearch - UK (3)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
Toxins have been thoroughly studied for their use as therapeutic agents in search of an improvement in toxic efficiency together with a minimization of their undesired side effects. Different studies have shown how toxins can follow different intracellular pathways which are connected with their cytotoxic action inside the cells. The work herein presented describes the different pathways followed by the ribotoxin a-sarcin and the fungal RNase T1,as toxic domains of immunoconjugates with identical binding domain, the single chain variable fragment of a monoclonal antibody raised against the glycoprotein A33. According to the results obtained both immunoconjugates enter the cells via early endosomes and, while a-sarcin can translocate directly into the cytosol to exert its deathly action, RNase T1 follows a pathway that involves lysosomes and the Golgi apparatus. These facts contribute to explaining the different cytotoxicity observed against their targeted cells, and reveal how the innate properties of the toxic domain, apart from its catalytic features, can be a key factor to be considered for immunotoxin optimization.