1 resultado para Statistical experimental design
em National Center for Biotechnology Information - NCBI
Filtro por publicador
- Aberdeen University (1)
- Abertay Research Collections - Abertay University’s repository (2)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (7)
- Aquatic Commons (13)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (6)
- Aston University Research Archive (16)
- Avian Conservation and Ecology - Eletronic Cientific Hournal - Écologie et conservation des oiseaux: (1)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (6)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (13)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (5)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (9)
- Brock University, Canada (11)
- Bulgarian Digital Mathematics Library at IMI-BAS (1)
- CaltechTHESIS (2)
- Cambridge University Engineering Department Publications Database (1)
- CentAUR: Central Archive University of Reading - UK (52)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (12)
- Cochin University of Science & Technology (CUSAT), India (9)
- Collection Of Biostatistics Research Archive (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Dalarna University College Electronic Archive (1)
- Deakin Research Online - Australia (60)
- Digital Commons at Florida International University (5)
- DigitalCommons@The Texas Medical Center (1)
- Duke University (4)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (6)
- Glasgow Theses Service (1)
- Helda - Digital Repository of University of Helsinki (8)
- Indian Institute of Science - Bangalore - Índia (6)
- INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES (IPEN) - Repositório Digital da Produção Técnico Científica - BibliotecaTerezine Arantes Ferra (1)
- Instituto Politécnico de Bragança (2)
- Instituto Politécnico do Porto, Portugal (2)
- National Center for Biotechnology Information - NCBI (1)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (1)
- Publishing Network for Geoscientific & Environmental Data (3)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (70)
- Queensland University of Technology - ePrints Archive (80)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (6)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (3)
- Repositório digital da Fundação Getúlio Vargas - FGV (2)
- Repositório Digital da UNIVERSIDADE DA MADEIRA - Portugal (1)
- Repositório Institucional da Universidade de Aveiro - Portugal (3)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (1)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (3)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (2)
- Repositorio Institucional de la Universidad de Málaga (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (378)
- Royal College of Art Research Repository - Uninet Kingdom (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (2)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (2)
- Universidade de Lisboa - Repositório Aberto (2)
- Universidade de Madeira (1)
- Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) (1)
- Universidade Federal de Uberlândia (3)
- Universidade Federal do Pará (4)
- Universidade Federal do Rio Grande do Norte (UFRN) (33)
- Universitat de Girona, Spain (5)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (6)
- Université de Montréal, Canada (20)
- University of Michigan (4)
- University of Queensland eSpace - Australia (7)
- University of Southampton, United Kingdom (1)
- WestminsterResearch - UK (1)
- Worcester Research and Publications - Worcester Research and Publications - UK (1)
Resumo:
The application of immunoprotein-based targeting strategies to the boron neutron-capture therapy of cancer poses an exceptional challenge, because viable boron neutron-capture therapy by this method will require the efficient delivery of 103 boron-10 atoms by each antigen-binding protein. Our recent investigations in this area have been focused on the development of efficient methods for the assembly of homogeneous immunoprotein conjugates containing the requisite boron load. In this regard, engineered immunoproteins fitted with unique, exposed cysteine residues provide attractive vehicles for site-specific modification. Additionally, homogeneous oligomeric boron-rich phosphodiesters (oligophosphates) have been identified as promising conjugation reagents. The coupling of two such boron-rich oligophosphates to sulfhydryls introduced to the CH2 domain of a chimeric IgG3 has been demonstrated. The resulting boron-rich immunoconjugates are formed efficiently, are readily purified, and have promising in vitro and in vivo characteristics. Encouragingly, these studies showed subtle differences in the properties of the conjugates derived from the two oligophosphate molecules studied, providing a basis for the application of rational design to future work. Such subtle details would not have been as readily discernible in heterogeneous conjugates, thus validating the rigorous experimental design employed here.