A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes.
Data(s) |
01/06/2016
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Resumo |
We examine how the interferon production of plasmacytoid dendritic cells is amplified by the self-assembly of liquid-crystalline antimicrobial peptide/DNA complexes. These specialized dendritic cells are important for host defense because they quickly release large quantities of type I interferons in response to infection. However, their aberrant activation is also correlated with autoimmune diseases such as psoriasis and lupus. In this review, we will describe how polyelectrolyte self-assembly and the statistical mechanics of multivalent interactions contribute to this process. In a more general compass, we provide an interesting conceptual corrective to the common notion in molecular biology of a dichotomy between specific interactions and non-specific interactions, and show examples where one can construct exquisitely specific interactions using non-specific interactions. |
Identificador |
https://serval.unil.ch/notice/serval:BIB_8C9D95A0BEF9 info:pmid:26956527 |
Idioma(s) |
eng |
Fonte |
Advances in colloid and interface science23217-24 |
Tipo |
info:eu-repo/semantics/review article |