Tratamiento del rechazo mediado por anticuerpos en pacientes trasplantados renales revisión sistemática
| Contribuinte(s) |
Molina Castaño, Carlos Federico |
|---|---|
| Data(s) |
20/09/2016
31/12/1969
|
| Resumo |
Antecedentes: El trasplante renal es la mejor alternativa terapéutica para la enfermedad renal crónica terminal. Los medicamentos inmunosupresores previenen el rechazo. El rechazo mediado por anticuerpos es frecuente y disminuye la función y duración del injerto. Objetivo: Evaluar sistemáticamente la evidencia disponible relacionada con la eficacia y seguridad del tratamiento para el rechazo mediado por anticuerpos en pacientes trasplantados renales. Metodologia: Revisión sistemática en bases de datos MEDLINE, EMBASE, Scopus y Biblioteca virtual de la salud. Literatura gris google scholar, google academico, www.clinicaltrialsregister.eu, and https://clinicaltrials.gov/. Búsqueda manual referencias artículos pre-seleccionados así como de revisiones previamente publicadas. Se siguieron las recomendacioes guia PRISMA para la identificacion de artículos potenciales, tamizaje y selección teniendo en cuenta los criterios de inclusion. Extracción datos de acuerdo a las variables, revisión calidad de los artículos elegidos utilizando evaluación riesgo de segos de Cochrane. Resultados: Se seleccionaron 9 ensayos clínicos publicados entre 1980 y 2016, incluyeron 222 pacientes (113 brazo de intervención y 109 en el control), seguimiento promedio 16 meses. Intervenciones evaluadas plasmaféresis, inmunoadsorción y rituximab. Hubo una amplia heterogeneidad en la definición de criterios de inclusión, criterios diagnósticos de rechazo y medidas de evaluación de eficacia de las intervenciones. Tres estudios encontraron diferencias estadísticamente significativas entre los grupos de tratamiento. Conclusiones: La evidencia sobre la eficacia de los tratamientos del rechazo mediado por anticuerpos en injertos renales es de baja calidad. Son necesarios ensayos clínicos controlados para poder definir el tratamiento óptimo de estos pacientes. Background: Kidney transplantation is the best therapeutic choice for end-stage chronic kidney disease (ES-CKD). Immunosuppressive drugs prevent rejection. Antibody mediated rejection is a frequent complication and implies a decrease in graft function and duration. This study is a systematic review to evaluate the evidence available regarding antibody mediated rejection treatment efficacy and safety in kidney transplant patients. Methods: Systematic review of databases MEDLINE, EMBASE, Scopus and Health Virtual Library (BVS in spanish). The grey literature sources were: google scholar, google academico, www.clinicaltrialsregister.eu, and https://clinicaltrials.gov/. There was a manual search of the references of every article pre-selected, as well as the review articles published previously. The PRISMA guidelines recommendations for identifying potential items, screening and selection were followed considering the inclusion criteria. Data according to variables were extracted and to asses the quality of the articles selected the evaluation of bias risk by Cochrane was used. Results: Nine clinical trials published 1980 and 2016 were selected, included 222 patients (113 at intervention arm, and 109 as control), with an average follow-up of 16 months. Interventions evaluated were plasmapheresis, immunoadsortion and rituximab. There was a wide heterogeneity in the definition of inclusion criteria, diagnostic criteria for rejection and assessment effectiveness of interventions. Three studies was able to demonstrate a statistical significance between treatment groups. Conclusion: The data describing the efficacy of treatments for antibody-mediated rejection in renal allografts are of low. Larger randomized controlled trials are required in order to define the optimal scheme of treatment for these patients. |
| Formato |
application/pdf |
| Identificador | |
| Idioma(s) |
spa |
| Publicador |
Facultad de medicina |
| Direitos |
info:eu-repo/semantics/embargoedAccess |
| Fonte |
instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant [Internet]. 2009 Nov;9 Suppl 3(Suppl 3):S1–155. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19845597 2. Instituto Nacional de Salud. Informe ejecutivo Red de Donacion y Trasplantes Colombia 2015 [Internet]. 2015 [cited 2016 Jun 17]. Available from: http://www.ins.gov.co/lineas-de-accion/Red-Nacional-Laboratorios/Estadsticas/Informe ejecutivo Red Donación y Trasplantes 1er semestre 2015.pdf Puttarajappa C, Shapiro R, Tan HP. Antibody-mediated rejection in kidney transplantation: a review. J Transplant [Internet]. 2012;2012:193724. Available from: http://www.hindawi.com/journals/jtrans/2012/193724/ Djamali A, Kaufman DB, Ellis TM, Zhong W, Matas A, Samaniego M. Diagnosis and management of antibody-mediated rejection: current status and novel approaches. Am J Transplant [Internet]. 2014 Feb;14(2):255–71. Available from: http://doi.wiley.com/10.1111/ajt.12589 Terasaki PI, Cai J. Human leukocyte antigen antibodies and chronic rejection: from association to causation. Transplantation [Internet]. 2008 Aug 15;86(3):377–83. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00007890-200808150-00002 Roberts DM, Jiang SH, Chadban SJ. The treatment of acute antibody-mediated rejection in kidney transplant recipients-a systematic review. Transplantation [Internet]. 2012;94(8):775–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23032865 Sis B, Mengel M, Haas M, Colvin RB, Halloran PF, Racusen LC, et al. Banff ’09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant [Internet]. 2010 Mar;10(3):464–71. Available from: http://doi.wiley.com/10.1111/j.1600-6143.2009.02987.x Abbas AK. Cellular and Molecular Immunology. 8th ed. Abbas AK, Lichtman A, Pillai S, editors. Elsevier Inc.; 2014. 359-382 p. Boros P, Bromberg JS. New cellular and molecular immune pathways in ischemia/reperfusion injury. Am J Transplant. 2006;6(4):652–8. Salvadori M, Rosso G, Bertoni E. Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant. 2015;5(2):52–67. Shrestha BM. Immunology for Renal Transplantation : A Review. J Transplant Technol Res. 2014;4(1):1–7. Manuscript A. Nihms181542. 2010;178(12):7503–9. Otterbein LE, Fan Z, Koulmanda M, Thronley T. Innate immunity for better or worse govern the allograft response. 2015;20(1):8–12. Wood KJ, Goto R. Mechanisms of Rejection : Current Perspectives. 2012;93(1):1–10. Cheung KP, Kasimsetty SG, Mckay DB. Innate immunity in donor procurement. 2013;18(2):154–60. Denecke C, Tullius SG. Innate and adaptive immune responses subsequent to ischemia-reperfusion injury in the kidney. Prog Urol. Elsevier; 2014;24 Suppl 1:S13–9. Mckenna K, Beignon A, Bhardwaj N. Plasmacytoid Dendritic Cells : Linking Innate and Adaptive Immunity MINIREVIEW Plasmacytoid Dendritic Cells : Linking Innate and Adaptive Immunity. J Virol. 2005;79(1):17–27. Ezzelarab M, Thomson A. Tolerogenic dendritic cells and their role in transplantation. Semin Immunol. 2011;23(4):252–63. Kumbala D, Zhang R. Essential concept of transplant immunology for clinical practice. World J Transplant. 2013;3(4):113–8. Thorsby E. A short history of HLA. 2009;(5):101–16. Nguyen H Do, Williams RL, Wong G, Lim WH. The Evolution of HLA-Matching in Kidney Transplantation. 2013; Dewolf S, Shen Y, Sykes M. A New Window into the Human Alloresponse. 2016;00(00):1–11. Chen W, Ghobrial RM, Li XC. The Evolving Roles of Memory Immune Cells in Transplantation. 2015;99(10). Schwartz RS, Nankivell BJ, Alexander SI. mechanisms of disease Rejection of the Kidney Allograft. N Engl J Med. 2010;363:1451–62. Haas M, Sis B, Racusen LC, Solez K, Paolo S, Paolo S. Banff 2013 Meeting Report : Inclusion of C4d-Negative Antibody-Mediated Rejection and Antibody-Associated Arterial Lesions. 2014;272–83. Collins AB, Schneeberger EE, Pascual MA, Saidman SL, Williams WW, Tolkoff-rubin N, et al. Complement Activation in Acute Humoral Renal Allograft Rejection : Diagnostic Significance of C4d Deposits in Peritubular Capillaries. 1999;(11):2208–14. Touzot M, Nnang E, Beaudreuil S, François H, Durrbach A. Complement modulation in solid-organ transplantation. Transplant Rev [Internet]. Elsevier Inc.; 2014;28(3):119–25. Available from: http://dx.doi.org/10.1016/j.trre.2014.03.001 Sheen JH, Heeger PS. Effects of complement activation on allograft injury. 2015; Wedel J, Bruneau S, Kochupurakkal N, Boneschansker L, Briscoe DM. Chronic allograft rejection: a fresh look. Curr Opin Organ Transplant. 2015;20(1):13–20. Cai J, Terasaki PI. Humoral theory of transplantation: Mechanism, prevention, and treatment. Hum Immunol. 2005;66(4):334–42. Bromberg JS, Fairchild RL, Feng S, Kaplan B, Barr ML, Grady JO, et al. Supplement 3 • vol 9 • 2009. 2009;9. Muduma G, Odeyemi I, Smith-Palmer J, Pollock RF. Review of the Clinical and Economic Burden of Antibody-Mediated Rejection in Renal Transplant Recipients. Adv Ther. Springer Healthcare; 2016;33(3):345–56. Lefaucheur C, Loupy A, Hill GS, Andrade J, Nochy D, Antoine C, et al. Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation. J Am Soc Nephrol. 2010;21(8):1398–406. Wiebe C, Gibson IW, Blydt-Hansen TD, Karpinski M, Ho J, Storsley LJ, et al. Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant. Am J Transplant. 2012;12(5):1157–67. Gebel HM, Bray RA. Approaches for transplanting the sensitized patient: Biology versus pharmacology. Nephrol Dial Transplant. 2008;23(8):2454–7. Fehr T, Gaspert A. Antibody-mediated kidney allograft rejection: Therapeutic options and their experimental rationale. Transpl Int. 2012;25(6):623–32. Sharma S, Oliver K, W D. Advances in Antibody Mediated Rejection BT - (null). 2013;(Chapter 20). Pascual, Manuel; Saidman, Susan; Tolkoff-Rubin, Nina; Williams, Winfred W.; Mauiyyedi, Shamila; Duan, Ji Ming; Farrell, Mary Lin; Colvin, Robert B.; Cosimi, A. Benedict; Delmonico FL. Plasma exchange and tacrolimus-mycophenolate rescue for acute humoral rejection in kidney transplantation. Transplantation. 1998;66(11):1460–4. Rummler S, Barz D. Plasma exchange and immunoadsorption of patients with thoracic organ transplantation. Transfus Med Hemotherapy. 2012;39(4):234–40. Böhmig GA, Wahrmann M, Regele H, Exner M, Robl B, Derfler K, et al. Immunoadsorption in severe C4d-positive acute kidney allograft rejection: a randomized controlled trial. Am J Transplant [Internet]. 2007 Jan;7(1):117–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17109725 Vo A a, Lukovsky M, Toyoda M, Wang J, Reinsmoen NL, Lai C-H, et al. Rituximab and intravenous immune globulin for desensitization during renal transplantation. N Engl J Med. 2008;359(3):242–51. Sautenet B, Blancho G, Büchler M, Morelon E, Toupance O, Barrou B, et al. One-year Results of the Effects of Rituximab on Acute Antibody-Mediated Rejection in Renal Transplantation: RITUX ERAH, a Multicenter Double-blind Randomized Placebo-controlled Trial. Transplantation [Internet]. 2016 Feb;100(2):391–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26555944 Everly MJ, Everly JJ, Susskind B, Brailey P, Arend LJ, Alloway RR, et al. Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection. Transplantation. 2008;86(12):1754–61. Flechner SM, Fatica R, Askar M, Stephany BR, Poggio E, Koo A, et al. The role of proteasome inhibition with bortezomib in the treatment of antibody-mediated rejection after kidney-only or kidney-combined organ transplantation. Transplantation. 2010;90(12):1486–92. Pascual J, Zuckermann A, Djamali A, Hertig A, Naesens M. Rabbit antithymocyte globulin and donor-specific antibodies in kidney transplantation — A review. Transplant Rev. The Authors; 2016;30(2):85–91. Zand MS. B-cell activity of polyclonal antithymocyte globulins. Transplantation. 2006;82(11):1387–95. Locke JE, Magro CM, Singer AL, Segev DL, Haas M, Hillel AT, et al. The use of antibody to complement protein C5 for salvage treatment of severe antibody-mediated rejection. Am J Transplant. 2009;9(1):231–5. Stegall MD, Diwan T, Raghavaiah S, Cornell LD, Burns J, Dean PG, et al. Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients. Am J Transplant. 2011;11(11):2405–13. Burbach M, Suberbielle C, Brochériou I, Ridel C, Mesnard L, Dahan K, et al. Report of the inefficacy of eculizumab in two cases of severe antibody-mediated rejection of renal grafts. Transplantation. 2014;98(10):1056–9. Locke JE, Zachary AA, Haas M, Melancon JK, Warren DS, Simpkins CE, et al. The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection. Am J Transplant. 2007;7(4):842–6. Welch V, Petticrew M, Petkovic J, Moher D, Waters E, White H, et al. Extending the PRISMA statement to equity-focused systematic reviews (PRISMA-E 2012): explanation and elaboration. Int J Equity Health [Internet]. 2015;14:92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26450828 Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol [Internet]. 2009 Oct;62(10):e1–34. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19631507 Search MEDLINE/PubMed via PICO with Spelling Checker [Internet]. Available from: https://pubmedhh.nlm.nih.gov/nlmd/pico/piconew.php Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ [Internet]. 2011;343(oct18 2):d5928. Available from: http://www.bmj.com/cgi/doi/10.1136/bmj.d5928 Bonomini V, Vangelista A, Frascà GM, Di Felice A, Liviano D’Arcangelo G. Effects of plasmapheresis in renal transplant rejection. A controlled study. Trans Am Soc Artif Intern Organs [Internet]. 1985;31:698–703. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3915622 Zarkhin V, Li L, Kambham N, Sigdel T, Salvatierra O, Sarwal MM. A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation. Am J Transplant [Internet]. 2008 Dec;8(12):2607–17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18808404 Allen NH, Dyer P, Geoghegan T, Harris K, Lee HA, Slapak M. Plasma exchange in acute renal allograft rejection. A controlled trial. Transplantation [Internet]. 1983 May;35(5):425–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6342220 Kirubakaran MG, Disney AP, Norman J, Pugsley DJ, Mathew TH. A controlled trial of plasmapheresis in the treatment of renal allograft rejection. Transplantation [Internet]. 1981 Aug;32(2):164–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/7027553 Soulillou JP, Guyot C, Guimbretiere J, Girard M, Ythier A, Bignon JD, et al. Plasma exchange in early kidney graft rejection associated with anti-donor antibodies. Nephron [Internet]. 1983;35(3):158–62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6355877 Zhu D, Qi G, Tang Q, Li L, Yang C, Lin M, et al. Combination of Total Lymphoid Irradiation, Low-Dose IVIG and ATG as Rescue Therapy for Highly Sensitized and Antibody-Mediated Rejection Renal Transplant Recipients. Clin Transpl [Internet]. 2014;215–21. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26281148 Blake P, Sutton D, Cardella CJ. Plasma exchange in acute renal transplant rejection. Prog Clin Biol Res [Internet]. 1990;337:249–52. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2191316 Haas M, Sis B, Racusen LC, Solez K, Glotz D, Colvin RB, et al. Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant [Internet]. 2014 Feb;14(2):272–83. Available from: http://doi.wiley.com/10.1111/ajt.12590 Lefaucheur C, Nochy D, Andrade J, Verine J, Gautreau C, Charron D, et al. Comparison of combination Plasmapheresis/IVIg/anti-CD20 versus high-dose IVIg in the treatment of antibody-mediated rejection. Am J Transplant [Internet]. 2009 May;9(5):1099–107. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19422335 Allen N, Dyer P, Geoghegan T, Harris K, Lee H, Slapak M. PLASMA EXCHANGE IN ACUTE RENAL ALLOGRAFT REJECTION. Transplantation. 1983;35(5):425–8. KirubakaranM., Disney A, Norman J, Pugsley D, Mathew T. A CONTROLLED TRIAL OF PLASMAPHERESIS IN THE TREATMENT OF RENAL ALLOGRAFT REJECTION. Transplantation. 1981;32(2):164–5. Eskandary F. Bortezomib in Late Antibody-mediated Kidney Transplant Rejection (BORTEJECT) [Internet]. Available from: https://clinicaltrials.gov/ct2/results?term=NCT01873157&Search=Search Legendre C. Bortezomib in Rejection of Kidney Transplants (TRIBUTE) [Internet]. Available from: https://clinicaltrials.gov/ct2/results?term=NCT02201576&Search=Search Kulkarni S. Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation [Internet]. Available from: https://clinicaltrials.gov/ct2/results?term=NCT01327573&Search=Search |
| Palavras-Chave | #Epidemiología #614.4 #Epidemiología #Enfermedades renales #Inmunología del trasplante #kidney transplantation #antibody mediated rejection #graft rejection #graft survival |
| Tipo |
info:eu-repo/semantics/masterThesis info:eu-repo/semantics/acceptedVersion |
