Revisión sistemática utilidad de asa y calcio con o sin vitamina d en la prevención de cáncer colorrectal y la recurrencia de pólipos adenomatosos en paciente con riesgo de padecer esta patología
| Contribuinte(s) |
Zapata, Carolina |
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| Data(s) |
30/04/2016
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| Resumo |
Introducción: El cáncer colorrectal es una patología con alto impacto en la salud pública, debido a su prevalencia, incidencia, severidad, costo e impacto en la salud mental y física del individuo y la familia. Ensayos clínicos realizados en pacientes con antecedente de infarto al miocardio que consumían ácido acetil salicílico (asa), calcio con y sin vitamina D, mostraron asociación entre el consumo de estos medicamentos y disminución en la incidencia en cáncer colorrectal y pólipos adenomatosos. Objetivo: Evaluar la literatura sobre el uso de asa, calcio con y sin vitamina D con relación a su impacto en la prevención del cáncer colorrectal y pólipos adenomatosos. Métodos: Se realizó revisión sistemática buscando ensayos clínicos realizados en pacientes con factores de riesgo para cáncer colorrectal y pólipos adenomatosos que usaron asa, calcio con y sin vitamina D fueron incluidos. Resultados: se escogieron 105 para la revisión sistemática. Conclusiones: Es necesario desarrollar más estudios que lleven a evaluar el efecto protector de la aspirina, calcio y vitamina D. En los artículos revisados la aspirina a dosis de 81 a 325 mg día se correlaciona con reducción de riesgo de aparición de CRC aunque la dosis ideal, el tiempo de inicio y la duración de la ingesta continua no son claros. Hacen falta estudios que comparen poblaciones con ingesta de asa a diferentes dosis. Introduction: Colorectal cancer is a disease with high impact on public health, because of its prevalence, incidence, severity, cost and impact on mental and physical health of the individual and the family. Clinical trials in patients with a history of myocardial infarction who consumed acetylsalicylic acid (ASA), calcium with vitamin D without showed association between consumption of these drugs and decreased incidence in colorectal cancer and adenomatous polyps. Objective: To evaluate the literature on the use of ASA, calcium and vitamin D without regard to their impact on the prevention of colorectal cancer and adenomatous polyps. Methods: A systematic review was conducted clinical trials looking at different databases in patients with risk factors for colorectal cancer and adenomatous polyps that used asa, calcium and vitamin D were included. Exclusion criteria: were excluded from studies in people who have had colorectal cancer, Lynch syndrome, familial adenomatous polyposis, animal studies. literature was included from 1990 onwards. Results: After entering the terms Mesh and Desc, the application of inclusion and exclusion criteria, qualify literature and eliminate duplicates, 105 were selected for the systematic review. Conclusions: It is necessary to develop more studies leading to evaluate the protective effect of aspirin, calcium and vitamin D. In the revised aspirin at doses of 81-325 mg daily items correlates with reduced risk of CRC although the dose ideal start time and duration of continuous intake are unclear. Studies are needed to compare populations with intake asa at different doses. |
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application/pdf |
| Identificador | |
| Idioma(s) |
spa |
| Publicador |
Facultad de medicina |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
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| Palavras-Chave | #Epidemiología #614.4 #Epidemiología #Neoplasias colorrectales #Pólipos del colon #Mortalidad #COLORECTAL CANCER #PROPHYLAXIS #ACETYL SALICYLIC ACID #CALCIUM #VITAMIN D |
| Tipo |
info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/acceptedVersion |
