Índice del perfil del donante renal (KDPI) como factor pronóstico del trasplante
| Contribuinte(s) |
Sanabria, Mauricio |
|---|---|
| Data(s) |
05/05/2016
|
| Resumo |
La enfermedad renal crónica ha aumentado a nivel mundial y nacional, mientras que el número de donantes viene en descenso, y los pacientes en lista de espera aumentan. Los donantes cadavéricos son una opción para estos pacientes, y han sido utilizados en últimos años para aumentar los órganos disponibles. La evaluación de la calidad de estos es importante para optimizar su uso. Estudio analítico tipo cohorte retrospectiva, cálculo de KDPI en donantes cadavéricos, seguimiento función renal creatinina sérica 1 mes, 3 meses, 6 meses y un año. Correlación supervivencia del injerto, función renal, KDPI y EPTS. Análisis de supervivencia y regresión logística con variables del donante, receptor y acto quirúrgico. End stage chronic kidney disease has been rising its numbers worldwide and nationally, meanwhile the number of organ donors has been showing a decrease in its numbers, and the wait-listed number of patients are growing every day. Cadaveric organ donors are a good option for these patients, and are used in order to increase the number of organs available for transplantation. The evaluation of the quality of these organs for transplantation is critical in order to optimize its use. This is a retrospective cohort study in which we calculated de Kidney Donor Profile Index (KDPI) in cadaveric organ donors, with creatinine follow up at 1 month, 3 months, 6 months and a year. We then analyzed graft survival, renal function, KDPI and EPTS. Finally, we analyzed graft and patient survival and a logistic regression using variables from de donor, recipient and surgical procedure. |
| Formato |
application/pdf |
| Identificador | |
| Idioma(s) |
spa |
| Publicador |
Facultad de medicina |
| Direitos |
info:eu-repo/semantics/openAccess |
| Fonte |
instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR 1. Niño Murcia M. Informe Trasplantes Colombia 2014. 2014. 2. Tedla FM, Friedman E a. The Trend Toward Geriatric Nephrology. Prim Care - Clin Off Pract. 2008;35(3):515–30. 3. Rao PS, Schaubel DE, Guidinger MK, Andreoni K a, Wolfe R a, Merion RM, et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation. 2009;88(2):231–6. 4. OPTN, SRTR, UNOS. A Guide to Calculating and Interpreting the Kidney Donor Profile Index ( KDPI ). 2012;1–12. 5. Niño Murcia M. Informe Trasplantes en Colombia 2013. 2013. 6. Instituto Nacional de Salud. Informe anual red donación y trasplantes. 2013;3:127. 7. Alberu J. Comercio de órganos en Latinoamérica. 8. Acuña L, Sanchez P, Soler L, Barrera A, Torres L, Casas L, et al. Situación ERC Colombia 2014 [Internet]. Bogotá, Colombia; 2015. Available from: http://www.cuentadealtocosto.org/byblos/Docs/SITUACION ECR COLOMBIA 2014.swf 9. Wolfe R, Ashby VB, Milford EL, Akinlolu O O, Ettenger RE, Agodoa LY, et al. Mortality in patients on dialysis and transplant recipients: comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first transplant. N Engl J Med. 1999;341(Number 23):1725–30. 10. Cameron JI, Whiteside C, Katz J, Devins GM. Differences in quality of life across renal replacement therapies: a meta-analytic comparison. Am J Kidney Dis. 2000;35(4):629–37. 11. Gill JS, Tonelli M, Johnson N, Kiberd B, Landsberg D, Pereira BJG. The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation. Kidney Int. 2005;68(5):2345–51. 12. Hernandez RA, Malek SK, Milford EL, Finlayson SRG, Tullius SG. The Combined Risk of Donor Quality and Recipient Age. Transplantation. 2014;98(10):1069–76 13. Merion RM, Ashby VB, Wolfe R a, Distant D a, Hulbert-Shearon TE, Metzger R a, et al. Deceased-donor characteristics and the survival benefit of kidney transplantation. JAMA. 2005;294(21):2726–33. 14. Matas AJ, Smith JM, Skeans MA, Thompson B, Gustafson SK, Stewart DE, et al. OPTN/SRTR 2013 Annual Data Report: 2013; 15. Matesanz Rafael. International Figures on Newsletter Transplant. 2013; 16. Salinas M. Informe anual Red de Donación y Trasplante. 2011. 17. Gandolfini I, Buzio C, Zanelli P, Palmisano A, Cremaschi E, Vaglio A, et al. The Kidney Donor Profile Index (KDPI) of Marginal Donors Allocated by Standardized Pretransplant Donor Biopsy Assessment: Distribution and Association With Graft Outcomes. Am J Transplant. 2014;14(11):2515–25. 18. Gupta A, Chen G, Kaplan B. KDPI and Donor Selection. Am J Transplant. 2014;14(11):2444–5. 19. Lee P.K. A, Abramowicz D. Is the Kidney Donor Risk Index a step forward in the assessment of deceased donor kidney quality? Nephrol Dial Transplant. 2014;1–6. 20. Mohamed N, Cornell LD. Donor Kidney Evaluation. Surg Pathol Clin. Elsevier Inc; 2014;7(3):357–65. 21. Massie a. B, Luo X, Chow EKH, Alejo JL, Desai NM, Segev DL. Survival Benefit of Primary Deceased Donor Transplantation With High-KDPI Kidneys. Am J Transplant. 2014;14(10):2310–6. 22. Metzger R a, Delmonico FL, Feng S, Port FK, Wynn JJ, Merion RM. Expanded criteria donors for kidney transplantation. Am J Transplant. 2003;3 Suppl 4:114–25. 23. Kasiske BL, Stewart DE, Bista BR, Salkowski N, Snyder JJ, Israni AK, et al. The role of procurement biopsies in acceptance decisions for kidneys retrieved for transplant. Clin J Am Soc Nephrol. 2014;9(3):562–71. 24. Hwang JK, Park SC, Kwon KH, Choi BS, Kim JI, Yang CW, et al. Long-term outcomes of kidney transplantation from expanded criteria deceased donors at a single center: Comparison with standard criteria deceased donors. Transplant Proc. Elsevier Inc.; 2014;46(2):431–6. 25. Tso PL. Access to renal transplantation for the elderly in the face of new allocation policy: A review of contemporary perspectives on “older” issues. Transplant Rev. Elsevier Inc.; 2014;28(1):6–14. 26. Kauffman H, Bennet L, McBride M, Ellison M. The Expanded Donor. Transplant Rev. 1997;II(4). 27. Messina M, Fop F, Gallo E, Tamagnone M, Segoloni GP. Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidney transplantation. Transplant Proc. Elsevier Inc.; 2010;42(6):2209–13. 28. Stratta RJ, Rohr MS, Sundberg AK, Farney AC, Hartmann EL, Moore PS, et al. Intermediate-term outcomes with expanded criteria deceased donors in kidney transplantation: a spectrum or specter of quality? Ann Surg. 2006;243(5):594–601; discussion 601–3. 29. Woodside KJ, Merion RM, Leichtman a. B, De Los Santos R, Arrington CJ, Rao PS, et al. Utilization of kidneys with similar kidney donor risk index values from standard versus expanded criteria donors. Am J Transplant. 2012;12(8):2106–14. 30. OPTN, SRTR, UNOS. A Guide to Calculating and Interpreting the Estimated Post-Transplant Survival ( EPTS ) Score Used in the Kidney Allocation System ( KAS ) A Guide to Calculating and Interpreting the Estimated Post-Transplant Survival ( EPTS ) Score Used in the Kidney All. :1–9. 31. Rao PS, Merion RM, Ashby VB, Port FK, Wolfe R a, Kayler LK. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation. 2007;83(8):1069–74. 32. Huang E, Poommipanit N, Sampaio MS, Kuo H-T, Reddy P, Gritsch HA, et al. Intermediate-term outcomes associated with kidney transplantation in recipients 80 years and older: an analysis of the OPTN/UNOS database. Transplantation. 2010;90(9):974–9. 33. Meier-Kriesche H-U, Kaplan B. Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes: a paired donor kidney analysis. Transplantation. 2002;74(10):1377–81. 34. Baskin-Bey ES, Nyberg SL. Matching graft to recipient by predicted survival: can this be an acceptable strategy to improve utilization of deceased donor kidneys? Transplant Rev. 2008;22(3):167–70. 35. Arnau A, Rodrigo E, Miñambres E, Ruiz JC, Ballesteros MA, Piñera C, et al. Prediction of kidney transplant outcome by donor quality scoring systems: Expanded criteria donor and deceased donor score. Transplant Proc. Elsevier Inc.; 2012;44(9):2555–7. 36. Cecka JM, Cohen B, Rosendale J, Smith M. Could more effective use of kidneys recovered from older deceased donors result in more kidney transplants for older patients? Transplantation. 2006;81(7):966–70. 37. Tso PL, Dar WA, Henry ML. With respect to elderly patients: Finding kidneys in the context of new allocation concepts. Am J Transplant. 2012;12(5):1091–8. 38. Hopfer H, Kemény É. Assessment of donor biopsies. Curr Opin Organ Transplant. 2013;18(3):306–12. 39. Azancot MA, Moreso F, Salcedo M, Cantarell C, Perello M, Torres IB, et al. The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors. Kidney Int. 2013;1–8. 41. Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am J Transplant. 2011;11(11):2279–96. 42. Remuzzi G, Grinyò J, Ruggenenti P, Beatini M, Cole EH, Milford EL, et al. Early experience with dual kidney transplantation in adults using expanded donor criteria. Double Kidney Transplant Group (DKG). J Am Soc Nephrol. 1999;10(12):2591–8. 43. Munivenkatappa RB, Schweitzer EJ, Papadimitriou JC, Drachenberg CB, Thom K a., Perencevich EN, et al. The Maryland Aggregate Pathology Index: A deceased donor kidney biopsy scoring system for predicting graft failure. Am J Transplant. 2008;8(11):2316–24. 44. Asociación Medica Mundial. Declaración de Helsinki- Principios éticos para las investigaciones médicas en seres humanos. ONU 2008. 45. DHHS. Reglamento DHHS 45 CFR 46. 2005. 46. Cubillos Gutiérrez J, Sandoval Riveros CL, Andrade Cerquera E, Hermida Gutiérrez NH. Causas que contribuyen a la pérdida del trasplante renal de donante cadavérico en la Fundación Surcolombiana de Trasplantes. Febrero 2007 a noviembre de 2012, Neiva, Colombia. Rev Colomb Anestesiol. 2014;2(2):83–9. 47. Poggio ED, Hila S, Stephany B, Goldfarb D, Herts B, Dennis VW, et al. Donor Kidney Volume and Outcomes Following Live Donor Kidney Transplantation. 2006;(August 2005):616–24. 48. Giral M, Nguyen JM, Karam G, Kessler M, Ligny BH De, Buchler M, et al. Impact of Graft Mass on the Clinical Outcome of Kidney Transplants. :261–8. 49. Kasiske BL, Snyder JONJ, Gilbertson D. Inadequate Donor Size in Cadaver Kidney Transplantation. 2002;2152–9. 50. Moreso F, Seron D, Anunciada A, Hueso M, Ramon JM, Fundallosa, Xavier, Gil-Vernet S, et al. Recipient body surface area as a predictor of posttransplant renal allograft evolution. Clin Transplant. 65(5):671–6. 51. Zhang X, Huang H, Han S, Fu S, Wang L. Alemtuzumab induction in renal transplantation: A meta-analysis and systemic review. Transpl Immunol. Elsevier B.V.; 2012;27(2-3):63–8. 52. Morgan R, O’Callaghan J, Knight S. Alemtuzumab Induction Therapy in Kidney Transplantation: A Systematic Review and Meta-Analysis. Transplantation. 2012;93(12):1179–88. 53. Instituto Nacional de Salud. Informe anual red donación y trasplantes. INS. 2014;1–138. 54. Ponticelli CE. The impact of cold ischemia time on renal transplant outcome. Kidney Int. Nature Publishing Group; 2015;87(2):272–5. 55. Carrier M, Lizé JF. Impact of expanded criteria donors on outcomes of recipients after kidney transplantation. Transplant Proc. Elsevier Inc.; 2012;44(7):2227–30. 56. Messina M, Fop F, Gallo E, Tamagnone M, Segoloni GP. Analysis of four scoring systems and monocentric experience to optimize criteria for marginal kidney transplantation. Transplant Proc [Internet]. Elsevier Inc.; 2010;42(6):2209–13. Available from: http://dx.doi.org/10.1016/j.transproceed.2010.05.038 57. Gobierno Colombia, Ministerio Protección Social. Decreto Número 2493 de 2004. 2005;2005(Diciembre 26):1–31. 58. Schaier M, Seissler N, Becker LE, Schaefer SM, Schmitt E, Meuer S, et al. The extent of HLA-DR expression on HLA-DR+ Tregs allows the identification of patients with clinically relevant borderline rejection. Transpl Int. 2013;26(3):290–9. 59. Willicombe M, Brookes P, Sergeant R, Santos-Nunez E, Steggar C, Galliford J, et al. De Novo DQ Donor-Specific Antibodies Are Associated With a Significant Risk of Antibody-Mediated Rejection and Transplant Glomerulopathy. Transplant J. 2012;94(2):172–7. 60. Cassuto J, Reese P, Sonnad S, Bloom R, Levine M, Olthoff K, et al. Wait List Death and Survival Benefit of Kidney Transplantation among Nonrenal Trasplant Recipients. Am J Transplant. 2010;(10):2502–11. 61. Forbes JM, Cooper ME. Mechanisms of Diabetic Complications. Physiol Rev. 2013;93(1):137–88 62. Wood KJ, Goto R. Mechanisms of Rejection: Current Perspectives. Transplantation. 2012;93(1):1–10. |
| Palavras-Chave | #Epidemiología #614.4 #Epidemiología #Obtención de tejidos y órganos #Enfermedades renales #Epidemiología #Kidney donor profile index #KDPI #Graft survival #Cadaveric donor #Kidney transplantation |
| Tipo |
info:eu-repo/semantics/bachelorThesis info:eu-repo/semantics/acceptedVersion |
