Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?
Data(s) |
01/04/2016
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Resumo |
By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Elsevier |
Relação |
http://dro.deakin.edu.au/eserv/DU:30085158/tissot-docellautonomous-2016.pdf http://www.dx.doi.org/10.1016/j.bbcan.2016.01.005 |
Direitos |
2016, Elsevier |
Palavras-Chave | #Cancer #Ecology #Evolution #Mutations #Non-cell-autonomous effects |
Tipo |
Journal Article |