Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year


Autoria(s): Kennedy, Elizabeth A.; Connolly, Jennifer; Hourihane, Jonathan O'B.; Fallon, Padraic G.; McLean, W. H. Irwin; Murray, Deirdre; Jo, Jay-Hyun; Segre, Julia A.; Kong, Heidi H.; Irvine, Alan D.
Data(s)

06/01/2017

06/01/2017

05/09/2016

06/01/2017

Resumo

Background: Disease flares of established atopic dermatitis (AD) are generally associated with a low-diversity skin microbiota and Staphylococcus aureus dominance. The temporal transition of the skin microbiome between early infancy and the dysbiosis of established AD is unknown. Methods: We randomly selected 50 children from the Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) longitudinal birth cohort for microbiome sampling at 3 points in the first 6 months of life at 4 skin sites relevant to AD: the antecubital and popliteal fossae, nasal tip, and cheek. We identified 10 infants with AD and compared them with 10 randomly selected control infants with no AD. We performed bacterial 16S ribosomal RNA sequencing and analysis directly from clinical samples. Results: Bacterial community structures and diversity shifted over time, suggesting that age strongly affects the skin microbiome in infants. Unlike established AD, these patients with infantile AD did not have noticeably dysbiotic communities before or with disease and were not colonized by S aureus. In comparing patients and control subjects, infants who had affected skin at month 12 had statistically significant differences in bacterial communities on the antecubital fossa at month 2 compared with infants who were unaffected at month 12. In particular, commensal staphylococci were significantly less abundant in infants affected at month 12, suggesting that this genus might protect against the later development of AD. Conclusions: This study suggests that 12-month-old infants with AD were not colonized with S aureus before having AD. Additional studies are needed to confirm whether colonization with commensal staphylococci modulates skin immunity and attenuates development of AD.

Formato

application/pdf

Identificador

Kennedy, E. A., Connolly, J., Hourihane, J. O. B., Fallon, P. G., McLean, W. H. I., Murray, D., Jo, J.-H., Segre, J. A., Kong, H. H. and Irvine, A. D. (2017) 'Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year', Journal of Allergy and Clinical Immunology, 139(1), pp. 166-172. doi:10.1016/j.jaci.2016.07.029

139

1

166

172

0091-6749

http://hdl.handle.net/10468/3445

10.1016/j.jaci.2016.07.029

Journal of Allergy and Clinical Immunology

Idioma(s)

en

Publicador

Elsevier

Direitos

© 2016 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

http://creativecommons.org/licenses/by/4.0/

Palavras-Chave #Staphylococcus aureus #Atopic dermatitis #Skin #Microbiome #Longitudinal birth cohort #16S sequencing
Tipo

Article (peer-reviewed)