Cocaine-specific neuroplasticity in the ventral striatum network is linked to delay discounting and drug relapse
Data(s) |
01/12/2015
|
---|---|
Resumo |
AIMS: To contrast functional connectivity on ventral and dorsal striatum networks in cocaine dependence relative to pathological gambling, via a resting-state functional connectivity approach; and to determine the association between cocaine dependence-related neuroadaptations indexed by functional connectivity and impulsivity, compulsivity and drug relapse. DESIGN: Cross-sectional study of 20 individuals with cocaine dependence (CD), 19 individuals with pathological gambling (PG) and 21 healthy controls (HC), and a prospective cohort study of 20 CD followed-up for 12 weeks to measure drug relapse. SETTING AND PARTICIPANTS: CD and PG were recruited through consecutive admissions to a public clinic specialized in substance addiction treatment (Centro Provincial de Drogodependencias) and a public clinic specialized in gambling treatment (AGRAJER), respectively; HC were recruited through community advertisement in the same area in Granada (Spain). MEASUREMENTS: Seed-based functional connectivity in the ventral striatum (ventral caudate and ventral putamen) and dorsal striatum (dorsal caudate and dorsal putamen), the Kirby delay-discounting questionnaire, the reversal-learning task and a dichotomous measure of cocaine relapse indicated with self-report and urine tests. FINDINGS: CD relative to PG exhibit enhanced connectivity between the ventral caudate seed and subgenual anterior cingulate cortex, the ventral putamen seed and dorsomedial pre-frontal cortex and the dorsal putamen seed and insula (P≤0.001, kE=108). Connectivity between the ventral caudate seed and subgenual anterior cingulate cortex is associated with steeper delay discounting (P≤0.001, kE=108) and cocaine relapse (P≤0.005, kE=34). CONCLUSIONS: Cocaine dependence-related neuroadaptations in the ventral striatum of the brain network are associated with increased impulsivity and higher rate of cocaine relapse. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley |
Relação |
http://dro.deakin.edu.au/eserv/DU:30080446/albeinurios-cocainespecif-2015.pdf http://www.dx.doi.org/10.1111/add.13076 http://onlinelibrary.wiley.com/doi/10.1111/add.13076/abstract;jsessionid=AA6DDA774CD56A85E8C1B526032C0806.f04t03 |
Direitos |
2015, Wiley |
Palavras-Chave | #Cocaine #compulsivity #gambling #impulsivity #relapse #striatum #Science & Technology #Life Sciences & Biomedicine #Substance Abuse #Psychiatry #SUBSTANCE-USE DISORDERS #FUNCTIONAL CONNECTIVITY #DEPENDENT INDIVIDUALS #PREFRONTAL CORTEX #NUCLEUS-ACCUMBENS #DECISION-MAKING #PREDICTS #ADDICTION #CHOICE |
Tipo |
Journal Article |