Economic evaluation plan (EEP) for a very early rehabilitation trial (AVERT): an international trial to compare the costs and cost-effectiveness of commencing out of bed standing and walking training (very early mobilization) within 24 h of stroke onset
Data(s) |
01/06/2016
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Resumo |
RATIONALE: A key objective of A Very Early Rehabilitation Trial is to determine if the intervention, very early mobilisation following stroke, is cost-effective. Resource use data were collected to enable an economic evaluation to be undertaken and a plan for the main economic analyses was written prior to the completion of follow up data collection. AIM AND HYPOTHESIS: To report methods used to collect resource use data, pre-specify the main economic evaluation analyses and report other intended exploratory analyses of resource use data. SAMPLE SIZE ESTIMATES: Recruitment to the trial has been completed. A total of 2,104 participants from 56 stroke units across three geographic regions participated in the trial. METHODS AND DESIGN: Resource use data were collected prospectively alongside the trial using standardised tools. The primary economic evaluation method is a cost-effectiveness analysis to compare resource use over 12 months with health outcomes of the intervention measured against a usual care comparator. A cost-utility analysis is also intended. STUDY OUTCOME: The primary outcome in the cost-effectiveness analysis will be favourable outcome (modified Rankin Scale score 0-2) at 12 months. Cost-utility analysis will use health-related quality of life, reported as quality-adjusted life years gained over a 12 month period, as measured by the modified Rankin Scale and the Assessment of Quality of Life. DISCUSSION: Outcomes of the economic evaluation analysis will inform the cost-effectiveness of very early mobilisation following stroke when compared to usual care. The exploratory analysis will report patterns of resource use in the first year following stroke. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Sage |
Relação |
http://dro.deakin.edu.au/eserv/DU:30084756/sheppard-economicevaluation-2016.pdf http://dro.deakin.edu.au/eserv/DU:30084756/sheppard-economicevaluation-inpress-2016.pdf http://www.dx.doi.org/10.1177/1747493016632254 |
Direitos |
2016, World Stroke Organisation |
Palavras-Chave | #AVERT Trial Collaboration Group #Science & Technology #Life Sciences & Biomedicine #Peripheral Vascular Disease #Cardiovascular System & Cardiology |
Tipo |
Journal Article |