Anxiety, depression and fatigue at 5-year review following CNS demyelination
Data(s) |
01/01/2016
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Resumo |
BACKGROUND: Anxiety and depression are common in multiple sclerosis (MS). We evaluated the prevalence and factors associated with anxiety, depression and fatigue at the 5-year review of a longitudinal cohort study following a first clinical diagnosis of CNS demyelination (FCD). <br /><br />METHODS: Cases with a FCD were recruited soon after diagnosis and followed annually thereafter. A variety of environmental, behavioural and clinical covariates were measured at five-year review. Anxiety and depression were measured using the Hospital Anxiety & Depression Scale (HADS), and fatigue by the Fatigue Severity Scale (FSS). <br /><br />RESULTS: Of the 236 cases, 40.2% had clinical anxiety (median HADS-A: 6.0), 16.0% had clinical depression (median HADS-D: 3.0), and 41.3% had clinical fatigue (median FSS: 4.56). The co-occurrence of all three symptoms was 3.76 times greater than expectation. Younger age, higher disability, concussion or other disease diagnosis were independently associated with a higher anxiety score; male sex, higher disability, being unemployed, less physical activity, and antidepressant and/or anxiolytic-sedative medication use were independently associated with a higher depression score. Higher disability, immunomodulatory medication use, other disease diagnosis and anxiolytic-sedative medication use were independently associated with having fatigue, while female sex, higher BMI, having had a concussion, being unemployed and higher disability were associated with a higher fatigue score. <br /><br />CONCLUSION: These results support previous findings of the commonality of anxiety, depression and fatigue in established MS and extend this to post-FCD and early MS cases. The clustering of the three symptoms indicates that they may share common antecedents. |
Identificador | |
Idioma(s) |
eng |
Publicador |
John Wiley & Sons |
Relação |
http://dro.deakin.edu.au/eserv/DU:30082602/simpson-anxietydepression-2016.pdf http://dro.deakin.edu.au/eserv/DU:30082602/simpson-anxietydepression-inpress-2016.pdf http://www.dx.doi.org/10.1111/ane.12554 |
Direitos |
2016, John Wiley & Sons |
Palavras-Chave | #multiple sclerosis #prevalence #anxiety #depression #fatigue #first demyelinating event #Ausimmune/AusLong Investigators Group |
Tipo |
Journal Article |