Discovering the effects of omega-6 fatty acids on allergy using a HEK-Blue cell line
Data(s) |
01/01/2014
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Resumo |
In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. Allergic reactions can result in life-threatening situations causing morbidity and high economic cost. Therefore, more effective reagents are needed for allergy treatment. Omega-6 fatty acids have gained attention in allergic studies mainly due to their inflammatory properties. Literature suggests that a causal relationship exists between the intake of omega-6 fatty acids such as DPA and AA and atopic individuals suffering from allergies. In an allergic cascade, cytokines IL-4 and IL-13 bind to IL-4 receptor (IL-4R), which activates the STAT6 phosphorylation pathway leading to gene activation of allergen-specific IgE production by B cells. Consequently, IgE production leads to clinical symptoms of allergy. The overall aim of this study is to characterise DPA and AA and their effects on IgE production. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Wiley |
Relação |
http://dro.deakin.edu.au/eserv/DU:30071995/ahmed-dicoveringtheeffects-2014.pdf http://dx.doi.org/10.1111/all.12476 |
Direitos |
2014, The Authors |
Palavras-Chave | #Science & Technology #Life Sciences & Biomedicine #Allergy #Immunology |
Tipo |
Conference Paper |