Memory-enhancing effect of Rhodiola rosea L extract on aged mice
Cobertura |
Origin of publication: Nigeria |
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Data(s) |
22/09/2016
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Resumo |
Purpose: The memory-enhancing effects of Rhodiola rosea L. extract (RRLE) on normal aged mice were assessed. Methods: In the open-field test, the effect of RRLE (150 and 300 mg/kg) on mouse locomotive activities was evaluated by investigating the extract’s influence on CAT and AchE activities in the brain tissue of mice. Results: Compared with aged group, high dose of RRLE reduced the total distance (3212.4 ± 123.1 cm, p < 0.05) significantly, increased catalase (CAT) activity (101.4 ± 12.2 U/mg pro, p < 0.05), and inhibited acetyl cholinesterase (AChE) activity (0.94 ± 0.12 U/mg pro, p < 0.05) in the brain tissue of aged mice. Conclusion: The results show that RRLE improves the memory functions of aged mice probably by increasing CAT activity while decreasing AChE activity. |
Formato |
html |
Identificador | |
Idioma(s) |
en |
Publicador |
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria |
Relação |
http://www.tjpr.org; http://www.bioline.org.br/pr |
Direitos |
Copyright 2016 - Tropical Journal of Pharmaceutical Research |
Fonte |
Tropical Journal of Pharmaceutical Research (ISSN: 1596-5996) Vol 15 Num 7 |
Palavras-Chave | #Rhodiola rosea; Memory function; Catalase; Acetyl cholinesterase; Open-field test |
Tipo |
AA |