Protoporphyrin treatment modulates susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice
Data(s) |
01/12/2015
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Resumo |
We previously identified heme oxygenase 1 (HO-1) as a specific target of miR-155, and inhibition of HO-1 activity restored the capacity of miR-155-/- CD4+ T cells to promote antigendriven inflammation after adoptive transfer in antigen-expressing recipients. Protoporphyrins are molecules recognized for their modulatory effect on HO-1 expression and function. In the present study, we investigated the effect of protoporphyrin treatment on the development of autoimmunity in miR-155-deficient mice. MiR-155-mediated control of HO-1 expression in promoting T cell-driven chronic autoimmunity was confirmed since HO-1 inhibition restored susceptibility to experimental autoimmune encephalomyelitis (EAE) in miR-155- deficient mice. The increased severity of the disease was accompanied by an enhanced T cell infiltration into the brain. Taken together, these results underline the importance of miR- 155-mediated control of HO-1 expression in regulating the function of chronically-stimulated T cells in EAE. SCOPUS: ar.j info:eu-repo/semantics/published |
Formato |
No full-text files |
Identificador |
uri/info:doi/10.1371/journal.pone.0145237 http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/230634 |
Idioma(s) |
en |
Fonte |
PloS one, 10 (12 |
Palavras-Chave | #Psychologie appliquée #Sciences bio-médicales et agricoles #Biologie |
Tipo |
info:eu-repo/semantics/article info:ulb-repo/semantics/articlePeerReview info:ulb-repo/semantics/openurl/article |