Remote Ischemic Conditioning Influences Mitochondrial Dynamics
Contribuinte(s) |
Biologie Neurovasculaire et Mitochondriale Intégrée ; Université d'Angers (UA) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS) |
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Data(s) |
2015
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Resumo |
International audience <p>Remote ischemic preconditioning (RIPC) has emerged as an attractive strategy to protect the heart against ischemia-reperfusion (I/R) injury. The mechanisms by which remote ischemic conditioning (RIC) is protective are to date unknown, yet a well-accepted theory holds that the mitochondria play a central role. Mitochondria are dynamic organelles that undergo fusion and fission. Interventions that decrease mitochondrial fission or increase mitochondrial fusion have been associated with reduced I/R injury. However, whether RIPC influences mitochondrial dynamics or not has yet to be ascertained.We sought to determine the role played by mitochondrial dynamics in RIPC-induced cardioprotection. Male adult rats exposed in vivo to myocardial I/R were assigned to one of two groups, either undergoing 40 min of myocardial ischemia followed by 120 min of reperfusion (MI group) or four 5-min cycles of limb ischemia interspersed by 5 min of limb reperfusion, immediately prior to myocardial ischemia and 120 min of reperfusion (MI+RIPC group). After reperfusion, infarct size was assessed and myocardial tissue was analyzed by Western blot and electron microscopy. RIPC induced smaller infarct size (-28%), increased mitochondrial fusion protein OPA1, and preserved mitochondrial morphology. These findings suggest that mitochondrial dynamics play a role in the mechanisms of RIPC-induced cardioprotection.</p> |
Identificador |
hal-01392225 https://hal.archives-ouvertes.fr/hal-01392225 DOI : 10.1097/SHK.0000000000000500 OKINA : ua14259 |
Idioma(s) |
en |
Publicador |
HAL CCSD Lippincott, Williams & Wilkins |
Relação |
info:eu-repo/semantics/altIdentifier/doi/10.1097/SHK.0000000000000500 |
Fonte |
ISSN: 1073-2322 Shock https://hal.archives-ouvertes.fr/hal-01392225 Shock, Lippincott, Williams & Wilkins, 2015, pp.192-197. <http://journals.lww.com/shockjournal/pages/articleviewer.aspx?year=9000&issue=00000&article=98435&type=abstract>. <10.1097/SHK.0000000000000500> http://journals.lww.com/shockjournal/pages/articleviewer.aspx?year=9000&issue=00000&article=98435&type=abstract |
Palavras-Chave | #[SDV] Life Sciences [q-bio] |
Tipo |
info:eu-repo/semantics/article Journal articles |