Proteomics in the assessment of the therapeutic response of antineoplastic drugs: strategies and practical applications
Data(s) |
06/10/2016
06/10/2016
2016
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Resumo |
Uncovering mechanisms of unknown pathological mechanisms and body response to applied medication are the drive forces toward personalized medicine. In this post-genomic era, all eyes are tuned to proteomic field, searching for the answers and explanations by investigating the final physiological functional units – proteins and their proteoforms. Development of cutting-edge mass spectrometric technologies and powerful bioinformatics tools, allowed life-science community mining of disease-specific proteins as biomarkers, which are often hidden by high complexity of the samples and/or small abundance. Nowadays, there are several proteomics-based approaches to study the proteome. This chapter focuses on gold standard proteomics strategies and related issues towards candidate biomarker discovery, which may have diagnostic/prognostic as well as mechanistic utility. |
Identificador |
In: Rueff J, Rodrigues AS (eds.). Cancer Drug Resistance: Overviews and Methods, Springer, 2016: 281-298 978-1-4939-3347-1 |
Idioma(s) |
eng |
Relação |
http://www.springer.com/gp/book/9781493933457 |
Direitos |
embargoedAccess |
Palavras-Chave | #Genomica Funcional #Monitorização de Drogas #Genómica Funcional e Estrutural #Cancer #Chemotherapeutic Response #Discovery-based Proteomics #Proteomics #Target-proteomics |
Tipo |
bookPart |