The Influence of Estrogens on the Biological and Therapeutic Actions of Growth Hormone in the Liver
Data(s) |
03/11/2016
03/11/2016
2012
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Resumo |
<p>[EN]GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway</p> <p>[EN]GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway</p> |
Identificador |
http://hdl.handle.net/10553/18969 <p>10.3390/ph5070758</p> |
Idioma(s) |
eng |
Direitos |
Acceso libre by-nc-nd |
Fonte |
<p>Pharmaceuticals 2012, 5, 758-778</p> |
Palavras-Chave | #320101 Oncología |
Tipo |
info:eu-repo/semantics/article |