Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
Data(s) |
12/08/2016
12/08/2016
2015
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Resumo |
Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms. |
Identificador |
Case Rep Nephrol. 2015;2015:298261 http://hdl.handle.net/10400.17/2556 10.1155/2015/298261 |
Idioma(s) |
eng |
Publicador |
Hindawi Publishing Corporation |
Direitos |
openAccess |
Palavras-Chave | #HCC NEF #Dabigatran #Glomerulonephritis, IGA |
Tipo |
article |