Immunoglobulin heavy chain sequence analysis in Waldenstrom's macroglobulinemia and immunoglobulin M monoclonal gammopathy of undetermined significance.
Data(s) |
01/07/2006
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Resumo |
In this study, we used IGH sequence analysis to assess the maturational status of Waldenstrom's (WM) macroglobulinemia and its putative precursor immunoglobulin (Ig)-M monoclonal gammopathy of undetermined significance (MGUS). IGH sequence analysis was performed using standard methods in 23 cases (20 WM and 3 IgM MGUS as defined by consensus panel criteria). Waldenstrom's macroglobulinemia cases were characterized by heavily mutated IGH genes (median, 6.3%; range, 3.8%-13.9%) but without intraclonal variation (ICV). IgM MGUS was similarly characterized by somatic hypermutation (median, 7.5%; range, 7%-7.7%), but ICV was evident in 1 of the 3 cases. We would therefore conclude that WM is characterized by somatic hypermutation without ICV, which supports a derivation from postgerminal center/memory B cells. IgM MGUS is also characterized by somatic hypermutation but, in a manner similar to IgA/IgG MGUS, can be associated with ICV, although the significance of this remains unclear. |
Identificador | |
Idioma(s) |
eng |
Direitos |
info:eu-repo/semantics/restrictedAccess |
Fonte |
Rollett , R A , Wilkinson , E J , Gonzalez , D , Fenton , J A , Short , M A , Evans , P A , Rawstron , A C & Owen , R G 2006 , ' Immunoglobulin heavy chain sequence analysis in Waldenstrom's macroglobulinemia and immunoglobulin M monoclonal gammopathy of undetermined significance. ' CLINICAL LYMPHOMA & MYELOMA , vol 7 , no. 1 , pp. 70-72 . DOI: 10.3816/CLM.2006.n.042 |
Palavras-Chave | #Aged #Female #Gene Rearrangement #Humans #Immunoglobulin Heavy Chains #Immunoglobulin M #Male #Middle Aged #Mutation #Paraproteinemias #Sequence Analysis, DNA #Waldenstrom Macroglobulinemia |
Tipo |
article |