A cardiovascular occlusion method based on the use of a smart hydrogel
Data(s) |
10/06/2016
10/06/2016
04/09/2014
20/01/2015
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Resumo |
Smart hydrogels for biomedical applications are highly researched materials. However, integrating them into a device for implantation is difficult. This paper investigates an integrated delivery device designed to deliver an electro-responsive hydrogel to a target location inside a blood vessel with the purpose of creating an occlusion. The paper describes the synthesis and characterization of a Pluronic/methacrylic acid sodium salt electro-responsive hydrogel. Application of an electrical bias decelerates the expansion of the hydrogel. An integrated delivery system was manufactured to deliver the hydrogel to the target location in the body. Ex vivo and in vivo experiments in the carotid artery of sheep were used to validate the concept. The hydrogel was able to completely occlude the blood vessel reducing the blood flow from 245 to 0 ml/min after implantation. Ex vivo experiments showed that the hydrogel was able to withstand physiological blood pressures of > 270 mm·Hg without dislodgement. The results showed that the electro-responsive hydrogel used in this paper can be used to create a long-term occlusion in a blood vessel without any apparent side effects. The delivery system developed is a promising device for the delivery of electro-responsive hydrogels. |
Formato |
application/pdf |
Identificador |
Jackson, N., Verbrugghe, P., Cuypers, D., Adesanya, K., Engel, L., Glazer, P., Dubruel, P., Mendes, E., Herijigers, P. and Stam, F. (2014) 'A cardiovascular occlusion method based on the use of smart hydrogels', IEEE Transactions On Biomedical Engineering, 62(2), pp. 399-406. doi: 10.1109/TBME.2014.2353933 62 2 399 406 0018-9294 http://hdl.handle.net/10468/2715 10.1109/TBME.2014.2353933 IEEE Transactions on Biomedical Engineering |
Idioma(s) |
en |
Publicador |
IEEE |
Direitos |
© 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. |
Palavras-Chave | #Blood vessel #Cardiovascular #Delivery device #Electroactivation #Hydrogel #Occlusion |
Tipo |
Article (peer-reviewed) |