Genome-wide screening for DNA variants associated with reading and language traits
Data(s) |
01/09/2014
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Resumo |
Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome-wide association scan (GWAS) meta-analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading- and language-related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P≈10 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on-going international efforts to identify genes contributing to reading and language skills. Genome-wide association scan meta-analysis for reading and language ability. © 2014 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society. |
Formato |
application/pdf |
Identificador |
Gialluisi, A.; Newbury, D.F.; Wilcutt, E.G.; Olson, R.K.; DeFries, J.C.; Brandler, W.M.; Pennington, B.F.; Smith, S.D.; Scerri, T.S.; Simpson, N.H.; , SLI Consortium; Luciano, M.; Evans, D.M.; Bates, T.C.; Stein, J.F.; Talcott, J.B.; Monaco, A.P.; Paracchini, S.; Francks, C. and Fisher, S.E. (2014). Genome-wide screening for DNA variants associated with reading and language traits. Genes, Brain and Behavior, 13 (7), 686–701. |
Relação |
http://eprints.aston.ac.uk/23689/ |
Tipo |
Article PeerReviewed |