Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting


Autoria(s): Molenaar, Peter; Chen, Lu; Parsonage, William A.
Contribuinte(s)

H. Rang

Data(s)

01/01/2006

Resumo

There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that beta(2)-adrenoceptor agonists cause hypertrophy of skeletal muscle. Their use in clinical practice will also need an understanding of possible effects of activation of human heart beta(2)-adrenoceptors. Consequences could include an increased probability of arrhythmias in susceptible patients.

Identificador

http://espace.library.uq.edu.au/view/UQ:82735

Idioma(s)

eng

Publicador

Nature Publishing Group

Palavras-Chave #Pharmacology & Pharmacy #Skeletal Muscle #Muscle Wasting #Human Heart #Arrhythmias #Beta(2)-adrenoceptor #Formoterol #Salmeterol #Chronic Heart-failure #Rat Skeletal-muscles #Ventricular Myocardium #Cardiovascular Safety #Troponin-i #Receptor #Hypertrophy #Salbutamol #Relaxation #C1 #320502 Basic Pharmacology #730106 Cardiovascular system and diseases #CX
Tipo

Journal Article