Cardiac implications for the use of beta(2)-adrenoceptor agonists for the management of muscle wasting
Contribuinte(s) |
H. Rang |
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Data(s) |
01/01/2006
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Resumo |
There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that beta(2)-adrenoceptor agonists cause hypertrophy of skeletal muscle. Their use in clinical practice will also need an understanding of possible effects of activation of human heart beta(2)-adrenoceptors. Consequences could include an increased probability of arrhythmias in susceptible patients. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Nature Publishing Group |
Palavras-Chave | #Pharmacology & Pharmacy #Skeletal Muscle #Muscle Wasting #Human Heart #Arrhythmias #Beta(2)-adrenoceptor #Formoterol #Salmeterol #Chronic Heart-failure #Rat Skeletal-muscles #Ventricular Myocardium #Cardiovascular Safety #Troponin-i #Receptor #Hypertrophy #Salbutamol #Relaxation #C1 #320502 Basic Pharmacology #730106 Cardiovascular system and diseases #CX |
Tipo |
Journal Article |