Hypothalamic regulation of cortical bone mass: Opposing activity of Y2 receptor and leptin pathways
Contribuinte(s) |
J. A. Eisman |
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Data(s) |
01/01/2006
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Resumo |
NeuropeptideY-, Y2 receptor (Y2)-, and leptin-deficient mice show similar anabolic action in cancellous bone but have not been assessed in cortical bone. Cortical bone mass is elevated in Y2(-/-) mice through greater osteoblast activity. In contrast, leptin deficiency results in reduced bone mass. We show opposing central regulation of cortical bone. |
Identificador | |
Idioma(s) |
eng |
Publicador |
Blackwell Science Inc |
Palavras-Chave | #Endocrinology & Metabolism #Hypothalamus #Cortical Bone #Y2 Receptor #Leptin #Bone Formation #Osteoporotic Fracture #Ob/ob Mice #Strength #Ovariectomy #Growth #Women #Rats #Men #C1 #321017 Orthopaedics #730114 Skeletal system and disorders (incl. arthritis) |
Tipo |
Journal Article |