Concentration dependent effects of N1,N11-diethylnorspermine on melanoma cell proliferation


Autoria(s): Minchin, Rodney F.; Knight, Samuel; Arulpragasam, Ajanthy; Fogel-Petrovic, Mirjana
Contribuinte(s)

H zur Hausen

Data(s)

01/01/2006

Resumo

N-1, N-11-Diethylnorspermine (DENSPM) is a polyamine analog that is currently under investigation as a novel anticancer drug. Although it has shown promising preclinical activity, there has been large variation in responsiveness reported between different human cancers. During our studies into the causes of this variation, we observed a consistent increase in cell proliferation at low drug concentrations (

Identificador

http://espace.library.uq.edu.au/view/UQ:81650

Idioma(s)

eng

Publicador

John Wiley & Sons, Inc.

Palavras-Chave #Polyamine #Melanoma #Diethylnorspermine #Cell Proliferation #Cytotoxicity #Polyamine Analog N-1,n-11-diethylnorspermine #Spermidine-spermine N-1-acetyltransferase #Antitumor-activity #Carcinoma-cells #Lung-cancer #Drug-action #In-vitro #Phase-i #Growth #Gene #C1 #320501 Pharmaceutical Sciences and Pharmacy #730108 Cancer and related disorders
Tipo

Journal Article