Will diverse Tat interactions lead to novel antiretroviral drug targets?


Autoria(s): Harrich, D.; McMillan, N.; Munoz, L.; Apolloni, A.; Meredith, L.
Data(s)

01/12/2006

Resumo

More than fifteen years following the description of Tat as a critical HIV gene expression regulatory protein, additional roles for Tat in HIV replication have been described, including reverse transcription. Tat achieves function through direct interaction with viral proteins, including reverse transcriptase, and numerous cellular proteins including cyclin T1, RNA polymerase 11, protein kinase R (PKR), p300/CBP, and P/CAF. Despite our advanced knowledge of how Tat operates, this has not yet resulted in the discovery of effective agents capable of targeting various Tat functions. Nevertheless, Tat remains an attractive, virus-specific molecule and detailed understanding of specific protein interaction holds promise for future drug discovery.

Identificador

http://espace.library.uq.edu.au/view/UQ:81538

Idioma(s)

eng

Publicador

Bentham Science Publishers Ltd.

Palavras-Chave #Hiv-1 #Tat #Transcription #Reverse Transcription #Trans-activation #Acetylation #Methylation #Phosphorylation #Pharmacology & Pharmacy #Human-immunodeficiency-virus #Rna-polymerase-ii #Transcription Elongation-factor #Long-terminal Repeat #2nd Coding Exon #Nf-kappa-b #Type-1 Reverse Transcription #Dependent Protein-kinase #Human Cyclin T1 #Factor P-tefb #C1 #321015 Oncology and Carcinogenesis #730108 Cancer and related disorders
Tipo

Journal Article